Jonathan M Collins

US Patent:

7393920, Jul 1, 2008

Filed:

Jun 23, 2003

Appl. No.:

10/604022

Inventors:

Jonathan McKinnon Collins - Charlotte NC, US
Joseph Joshua Lambert - Charlotte NC, US
Michael John Collins - Charlotte NC, US

Assignee:

CEM Corporation - Matthews NC

International Classification:

A61K 38/04
A61K 38/00
C07K 5/00
C07K 7/00
C07K 16/00
C07K 17/00
C07K 1/00

US Classification:

530333, 530334, 530335, 530336, 530337

Abstract:

An instrument and process for accelerating the solid phase synthesis of peptides is disclosed. The method includes the steps of deprotecting a protected first amino acid linked to a solid phase resin by admixing the protected linked acid with a deprotecting solution in a microwave transparent vessel while irradiating the admixed acid and solution with microwaves, then activating a second amino acid by adding the second acid and an activating solution to the same vessel while irradiating the vessel with microwaves, then coupling the second amino acid to the first acid while irradiating the composition in the same vessel with microwaves, and cleaving the linked peptide from the solid phase resin by admixing the linked peptide with a cleaving composition in the same vessel while irradiating the composition with microwaves.

US Patent:

7550560, Jun 23, 2009

Filed:

Sep 26, 2005

Appl. No.:

11/235328

Inventors:

Jonathan McKinnon Collins - Charlotte NC, US
Joseph Joshua Lambert - Charlotte NC, US
Michael John Collins - Charlotte NC, US

Assignee:

CEM Corporation - Matthews NC

International Classification:

A61K 38/00
B01L 3/00

US Classification:

530333, 422 99

Abstract:

An instrument and process for accelerating the solid phase synthesis of peptides is disclosed. The method includes the steps of deprotecting a protected first amino acid linked to a solid phase resin by admixing the protected linked acid with a deprotecting solution in a microwave transparent vessel while irradiating the admixed acid and solution with microwaves, then activating a second amino acid by adding the second acid and an activating solution to the same vessel while irradiating the vessel with microwaves, then coupling the second amino acid to the first acid while irradiating the composition in the same vessel with microwaves, and cleaving the linked peptide from the solid phase resin by admixing the linked peptide with a cleaving composition in the same vessel while irradiating the composition with microwaves.

US Patent:

7563865, Jul 21, 2009

Filed:

Sep 26, 2005

Appl. No.:

11/235329

Inventors:

Jonathan McKinnon Collins - Charlotte NC, US
Joseph Joshua Lambert - Charlotte NC, US
Michael John Collins - Charlotte NC, US

Assignee:

CEM Corporation - Matthews NC

International Classification:

A61K 38/00
A01N 37/18

US Classification:

530333, 514 2, 530334, 530335, 530336, 530337

Abstract:

An instrument and process for accelerating the solid phase synthesis of peptides is disclosed. The method includes the steps of deprotecting a protected first amino acid linked to a solid phase resin by admixing the protected linked acid with a deprotecting solution in a microwave transparent vessel while irradiating the admixed acid and solution with microwaves, then activating a second amino acid by adding the second acid and an activating solution to the same vessel while irradiating the vessel with microwaves, then coupling the second amino acid to the first acid while irradiating the composition in the same vessel with microwaves, and cleaving the linked peptide from the solid phase resin by admixing the linked peptide with a cleaving composition in the same vessel while irradiating the composition with microwaves.

US Patent:

7582728, Sep 1, 2009

Filed:

Jun 23, 2008

Appl. No.:

12/143979

Inventors:

Jonathan McKinnon Collins - Charlotte NC, US
Joseph Joshua Lambert - Charlotte NC, US
Michael John Collins - Charlotte NC, US

Assignee:

CEM Corporation - Matthews NC

International Classification:

C07K 1/00
C07K 17/00
C07K 5/00
C07K 7/00
C07K 16/00
A61K 38/00

US Classification:

530333, 530334, 530335, 530336, 530337

Abstract:

An instrument and method for accelerating the solid phase synthesis of peptides is disclosed. The method includes the steps of deprotecting a protected first amino acid linked to a solid phase resin by admixing the protected linked acid with a deprotecting solution in a microwave transparent vessel while irradiating the admixed acid and solution with microwaves, then activating a second amino acid by adding the second acid and an activating solution to the same vessel while irradiating the vessel with microwaves, then coupling the second amino acid to the first acid while irradiating the composition in the same vessel with microwaves, and cleaving the linked peptide from the solid phase resin by admixing the linked peptide with a cleaving composition in the same vessel while irradiating the composition with microwaves.

US Patent:

7902488, Mar 8, 2011

Filed:

Oct 24, 2006

Appl. No.:

11/552153

Inventors:

Jonathan McKinnon Collins - Charlotte NC, US
Joseph Lambert - Charlotte NC, US

Assignee:

CEM Corporation - Matthews NC

International Classification:

H05B 6/64
C07K 5/00
C07K 7/00
C07K 16/00
C07K 17/00

US Classification:

219679, 530333

Abstract:

An instrument and associated method are disclosed for the accelerated synthesis of peptides by the solid phase method. The instrument includes a microwave cavity, a microwave source in communication with the cavity, a column in the cavity formed of a material that is transparent to microwave radiation, a solid phase peptide support resin in the column, respective filters for maintaining the solid phase support resin in the column, a first passageway for adding starting compositions to the column, a second passageway for removing compositions from the column, and a third passageway for circulating compositions from the column into the third passageway and back to the column.

US Patent:

7939628, May 10, 2011

Filed:

Sep 26, 2005

Appl. No.:

11/235027

Inventors:

Jonathan McKinnon Collins - Charlotte NC, US
Joseph Joshua Lambert - Charlotte NC, US
Michael John Collins - Charlotte NC, US

Assignee:

CEM Corporation - Matthews NC

International Classification:

A61K 38/00

US Classification:

530333, 530334, 530335, 530336, 530337

Abstract:

An instrument and process for accelerating the solid phase synthesis of peptides is disclosed. The method includes the steps of deprotecting a protected first amino acid linked to a solid phase resin by admixing the protected linked acid with a deprotecting solution in a microwave transparent vessel while irradiating the admixed acid and solution with microwaves, then activating a second amino acid by adding the second acid and an activating solution to the same vessel while irradiating the vessel with microwaves, then coupling the second amino acid to the first acid while irradiating the composition in the same vessel with microwaves, and cleaving the linked peptide from the solid phase resin by admixing the linked peptide with a cleaving composition in the same vessel while irradiating the composition with microwaves.

US Patent:

8058393, Nov 15, 2011

Filed:

Aug 28, 2009

Appl. No.:

12/549445

Inventors:

Jonathan McKinnon Collins - Charlotte NC, US
Joseph Joshua Lambert - Charlotte NC, US
Michael John Collins - Charlotte NC, US

Assignee:

CEM Corporation - Matthews NC

International Classification:

C07K 1/00
C07K 5/00
C07K 7/00
C07K 16/00
C07K 17/00
A61K 38/00

US Classification:

530333, 530335, 530336, 530337

Abstract:

An instrument and method for accelerating the solid phase synthesis of peptides are disclosed. The method includes the steps of deprotecting a protected first amino acid linked to a solid phase resin by admixing the protected linked acid with a deprotecting solution in a microwave transparent vessel while irradiating the admixed acid and solution with microwaves, activating a second amino acid, coupling the second amino acid to the first acid while irradiating the composition in the same vessel with microwaves, and cleaving the linked peptide from the solid phase resin by admixing the linked peptide with a cleaving composition in the same vessel while irradiating the composition with microwaves.

US Patent:

8153761, Apr 10, 2012

Filed:

Apr 30, 2009

Appl. No.:

12/433145

Inventors:

Jonathan McKinnon Collins - Charlotte NC, US
Joseph Joshua Lambert - Charlotte NC, US
Michael John Collins - Charlotte NC, US

Assignee:

CEM Corporation - Matthews NC

International Classification:

A61K 38/00
C07K 5/00
C07K 7/00
C07K 16/00
C07K 17/00

US Classification:

530333, 530334, 530335

Abstract:

An instrument and associated method are disclosed for the accelerated synthesis of peptides by the solid phase method. The instrument includes a microwave cavity, a microwave source in communication with the cavity, a column in the cavity formed of a material that is transparent to microwave radiation, a solid phase peptide support resin in the column, respective filters for maintaining the solid phase support resin in the column, a first passageway for adding starting compositions to the column, a second passageway for removing compositions from the column, and a third passageway for circulating compositions from the column into the third passageway and back to the column.