Joseph F Poduslo from Zumbro Falls, MN, age 78

Amino Acid Composition With Increased Blood Brain Barrier Permeability
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US Patent:

7279149, Oct 9, 2007
Filed:

Feb 10, 2004
Appl. No.:

10/775562
Inventors:

Joseph F. Poduslo - Rochester MN, US
Geoffrey L. Curran - Rochester MN, US
Thomas M. Wengenack - Rochester MN, US
Daniel J. McCormick - Rochester MN, US
Abdul H. Fauq - Jacksonville FL, US
Assignee:

Mayo Foundation for Medical Education and Research - Rochester MN
International Classification:

A61K 51/00
A61M 36/14
US Classification:

424 169, 424 111, 424 137, 424 165, 424 91
Abstract:

An amino acid composition with improved blood brain barrier permeability comprising an amino acid polymer, wherein the amino acid comprises at least one asparagyl-4-aminobutane or glutamyl-4-aminobutane residue.

Methods For Detecting Parenchymal Plaques In Vivo
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US Patent:

7371365, May 13, 2008
Filed:

Jan 27, 2003
Appl. No.:

10/351777
Inventors:

Joseph F. Poduslo - Rochester MN, US
Geoffrey L. Curran - Rochester MN, US
Thomas M. Wengenack - Rochester MN, US
Assignee:

Mayo Foundation for Medical Education and Research - Rochester MN
International Classification:

G09B 9/00
G09B 9/56
US Classification:

424 934, 424 91, 424 93, 424 9341
Abstract:

Methods for detecting parenchymal plaque deposits in the brain of a living mammal are described that include administering a polyamine modified, labeled polypeptide having specific binding affinity for the extracellular deposit, to the living mammal. Isolated β-amyloid peptides that are polyamine modified and labeled with a radioisotope or contrast agent also are described.

Treatment For Central Nervous System Disorders
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US Patent:

7988969, Aug 2, 2011
Filed:

Aug 31, 2009
Appl. No.:

12/550944
Inventors:

Joseph F. Poduslo - Rochester MN, US
Geoffry L. Curran - Rochester MN, US
Assignee:

MAYO Foundation for Medical Education and Research - Rochester MN
International Classification:

A61K 39/395
A61K 39/00
A61K 39/385
US Classification:

4241451, 4241301, 4241921, 4241931, 4241941, 514 11, 514 212, 514 178
Abstract:

Compositions that include an Aβ polypeptide linked to a non-Aβ polypeptide are described, as well as methods of using such compositions.

Treatment For Central Nervous System Disorders
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US Patent:

20030082191, May 1, 2003
Filed:

Aug 29, 2001
Appl. No.:

09/942253
Inventors:

Joseph Poduslo - Rochester MN, US
Geoffry Curran - Rochester MN, US
International Classification:

A61K039/395
A61K051/00
C12N009/00
US Classification:

424/178100, 435/188500, 424/001490
Abstract:

Compositions that include an A polypeptide linked to a non-A polypeptide are described, as well as methods of using such compositions.

Treatment For Central Nervous System Disorders
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US Patent:

20040142872, Jul 22, 2004
Filed:

Mar 9, 2004
Appl. No.:

10/796522
Inventors:

Joseph Poduslo - Rochester MN, US
Geoffry Curran - Rochester MN, US
Assignee:

Mayo Foundation for Medical Education and Research ,a MN corporation
International Classification:

A01K067/00
C07H021/04
A61K038/17
US Classification:

514/012000, 536/023500, 530/350000, 800/012000
Abstract:

Compositions that include an A polypeptide linked to a non-A polypeptide are described, as well as methods of using such compositions.

Magnetic Resonance Imaging Of Amyloid Plaque In The Brain
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US Patent:

20080262339, Oct 23, 2008
Filed:

Jun 28, 2005
Appl. No.:

11/631581
Inventors:

Michael G. Garwood - Medina MN, US
Clifford R. Jack - Rochester MN, US
Joseph F. Poduslo - Rochester MN, US
Thomas M. Wengenack - Rochester MN, US
International Classification:

A61B 5/055
US Classification:

600413
Abstract:

Amyloid plaque in the brain of a subject is imaged in an MRI system with or without the use of a contrast agent. Contrast is achieved using a spin-echo pulse sequence that is both respiratory gated and cardiac gated to reduce motion artifacts at the very high image resolution required to see plaque. A preparatory pulse sequence is used to insure longitudinal magnetization remains constant for all the acquired views even if the effective TR changes during the scan due to irregular breathing.

Methods For Detecting Parenchymal Plaques In Vivo
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US Patent:

20090028789, Jan 29, 2009
Filed:

Jan 18, 2008
Appl. No.:

12/009431
Inventors:

Joseph F. Poduslo - Rochester MN, US
Geoffry L. Curran - Rochester MN, US
Thomas M. Wengenack - Rochester MN, US
International Classification:

A61K 51/00
A61K 49/00
C07K 16/18
US Classification:

424 169, 424 934, 5303913
Abstract:

Methods for detecting parenchymal plaque deposits in the brain of a living mammal are described that include administering a polyamine modified, labeled polypeptide having specific binding affinity for the extracellular deposit, to the living mammal. Isolated β-amyloid peptides that are polyamine modified and labeled with a radioisotope or contrast agent also are described.

Peptide-Mediated Non-Covalent Delivery Of Active Agents Across The Blood-Brain Barrier
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US Patent:

20120107243, May 3, 2012
Filed:

Jul 14, 2010
Appl. No.:

13/383710
Inventors:

Geoffry L. Curran - Rochester MN, US
Gobinda Sarkar - Rochester MN, US
Joseph F. Poduslo - Rochester MN, US
Robert B. Jenkins - Rochester MN, US
Val J. Lowe - Rochester MN, US
Eric W. Mahlum - Rochester MN, US
Assignee:

MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH - Rochester MN
International Classification:

A61K 49/00
C07K 9/00
C07K 14/00
C07K 7/08
C07K 7/06
C07K 5/10
C07K 16/00
A61P 35/00
A61K 38/08
A61K 38/10
A61P 25/00
A61P 25/08
A61P 25/16
A61P 25/28
A61P 31/18
A61K 38/07
US Classification:

424 91, 514 12, 530322, 530324, 530325, 530326, 530327, 530328, 530329, 530330, 530359, 5303913
Abstract:

The peptides described herein can function as carrier peptides. These peptides can associate with (e.g., non-covalently bind) biologically active molecules or imaging agents to transport the biologically active molecules or imaging across the blood-brain barrier. In some cases, such transport may increase the effectiveness of the biological molecules or imaging agents.