Joseph L Simon

US Patent:

20200276553, Sep 3, 2020

Filed:

Mar 12, 2020

Appl. No.:

16/817299

Inventors:

Gabriel P. Lopez - Durham NC, US
Joseph R. Simon - Durham NC, US
Nick J. Carroll - Durham NC, US
Ashutosh Chilkoti - Durham NC, US

International Classification:

B01J 13/06
A61K 9/14
B01J 2/00
C07K 19/00
C07K 14/78
A61K 38/00
A61L 31/16
B01J 2/06
A61L 27/54
A61L 27/34
A61L 29/08
A61L 31/10
C12M 1/00

Abstract:

Nano- to microscale liquid coacervate particles are provided. The liquid coacervate particles are produced by a process including stimulating a population of liquid droplets containing one or a mixture of components to induce a phase separation point of a first component, and maintaining stimulation at the phase separation point to form a coacervate domain of the first component within each of the droplets to form the liquid coacervate particles. The self-assembled nano, meso, micro and macro liquid coacervate particles and related coated substrates can have utility in drug delivery, bioanalytical systems, controlled cell culture, tissue engineering, biomanufacturing and drug discovery.

US Patent:

20170216808, Aug 3, 2017

Filed:

Apr 14, 2017

Appl. No.:

15/487543

Inventors:

- Durham NC, US
Joseph R. Simon - Durham NC, US
Nick J. Carroll - Durham NC, US
Ashutosh Chilkoti - Durham NC, US

International Classification:

B01J 13/06
C12M 1/00
A61L 31/10
A61L 29/08
A61K 9/14
A61L 27/34

Abstract:

Nano- to microscale liquid coacervate particles are provided. The liquid coacervate particles are produced by a process including stimulating a population of liquid droplets containing one or a mixture of components to induce a phase separation point of a first component, and maintaining stimulation at the phase separation point to form a coacervate domain of the first component within each of the droplets to form the liquid coacervate particles. The self-assembled nano, meso, micro and macro liquid coacervate particles and related coated substrates can have utility in drug delivery, bioanalytical systems, controlled cell culture, tissue engineering, biomanufacturing and drug discovery.

US Patent:

20160271262, Sep 22, 2016

Filed:

Mar 18, 2016

Appl. No.:

15/074132

Inventors:

- Durham NC, US
Ashutosh Chilkoti - Durham NC, US
Ali Ghoorchian - Durham NC, US
Joseph R. Simon - Durham NC, US

International Classification:

A61K 47/48
A61K 9/06

Abstract:

The presently disclosed subject matter is directed to compositions, methods, and systems (e.g., platforms) comprising the same, the systems comprising, consisting of, or consisting essentially of micro- and macro-hydrogels that are formed from polypeptide micelles. The systems have enhanced mechanical properties that can be useful in a wide variety of applications, can be used for controlled release of drug-loaded micelles, and can be designed to reversibly assemble and disassemble on demand.