Jue Lin

US Patent:

20130289126, Oct 31, 2013

Filed:

Jun 24, 2011

Appl. No.:

13/703881

Inventors:

Owen M. Wolkowitz - Palo Alto CA, US
Synthia H. Mellon - San Francisco CA, US
Elissa S. Epel - San Francisco CA, US
Jue Lin - Foster City CA, US
Elizabeth H. Blackburn - San Francisco CA, US

Assignee:

THE REGENTS OF THE UNIVERSITY OF CALIFORNIA - Oakland CA

International Classification:

C12Q 1/68
A61K 31/135

US Classification:

514647, 435 612

Abstract:

The present invention provides methods of determining whether a subject is a suitable candidate for an anti-depressant treatment to alleviate a mood disorder by measuring telomere length and telomerase activity. The present invention also provides methods of assessing the efficacy of an anti-depressant treatment to alleviate a mood disorder and of predicting whether a subject is at risk of developing depression.

US Patent:

20190382841, Dec 19, 2019

Filed:

Jun 10, 2019

Appl. No.:

16/436357

Inventors:

- MENLO PARK CA, US
Jue Lin - Foster City CA, US
Yajing Hu - San Jose CA, US

International Classification:

C12Q 1/6883
C12Q 1/686

Abstract:

This invention provides methods and materials for measuring telomere abundance from chromosomes in a sample having telomeres within a pre-determined length range, e.g., short telomeres up to a certain length. The methods can involve a first step of performing a time-limited extension reaction calibrated to produce extension products from a double-stranded chromosomal DNA template of no more than a defined length, and a second step of amplifying, from the extension products, sequences bounded by a sub-telomeric sequence and the anchor sequence, to produce a length-limited telomere sequence product. The abundance of telomeric sequences in this product can be measured, and the measures can be correlated to a variety of indices.

US Patent:

20180237843, Aug 23, 2018

Filed:

Apr 16, 2018

Appl. No.:

15/954441

Inventors:

- MENLO PARK CA, US
Jue Lin - Foster City CA, US
Karl Guegler - Menlo Park CA, US

International Classification:

C12Q 1/6851
A61K 31/40
C12Q 1/686
A61K 35/28
A61K 35/12

Abstract:

Disclosed are methods and compositions for determining the average length or abundance of a first target nucleic by calculating the abundance of a first target nucleic acid (T) relative to the average abundance (S) of a second and a third target nucleic acid, in a single well using a separate detection label for each target nucleic acid. In various aspects, the first target nucleic acid is a telomere. In exemplary aspects, the disclosed methods and compositions can be used to determine the average telomere length in a biological sample. The average telomere length determined using the disclosed methods and compositions can be correlated to a variety of clinically important conditions and indices. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

US Patent:

20160186250, Jun 30, 2016

Filed:

Jun 22, 2015

Appl. No.:

14/746437

Inventors:

- Menlo Park CA, US
Jue Lin - Foster City CA, US
Karl Guegler - Menlo Park CA, US

International Classification:

C12Q 1/68
A61K 35/28

Abstract:

Disclosed are methods and compositions for determining the average length or abundance of a first target nucleic by calculating the abundance of a first target nucleic acid (T) relative to the average abundance (S) of a second and a third target nucleic acid, in a single well using a separate detection label for each target nucleic acid. In various aspects, the first target nucleic acid is a telomere. In exemplary aspects, the disclosed methods and compositions can be used to determine the average telomere length in a biological sample. The average telomere length determined using the disclosed methods and compositions can be correlated to a variety of clinically important conditions and indices. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

US Patent:

20160090630, Mar 31, 2016

Filed:

May 22, 2014

Appl. No.:

14/892395

Inventors:

- Menlo Park CA, US
Jue LIN - Foster City CA, US
Yajing HU - San Jose CA, US

International Classification:

C12Q 1/68

Abstract:

This invention provides methods and materials for measuring telomere abundance from chromosomes in a sample having telomeres within a pre-determined length range, e.g., short telomeres up to a certain length. The methods can involve a first step of performing a time-limited extension reaction calibrated to produce extension products from a double-stranded chromosomal DNA template of no more than a defined length, and a second step of amplifying, from the extension products, sequences bounded by a sub-telomeric sequence and the anchor sequence, to produce a length-limited telomere sequence product. The abundance of telomeric sequences in this product can be measured, and the measures can be correlated to a variety of indices.