Katherine E Stuart

US Patent:

20130190246, Jul 25, 2013

Filed:

Jun 23, 2011

Appl. No.:

13/806438

Inventors:

John E. Paderi - San Francisco CA, US
Alyssa Panitch - West Lafayette IN, US
Kinam Park - West Lafayette IN, US
Katherine Stuart - Phoenix AZ, US

Assignee:

PURDUE RESEARCH FOUNDATION - West Lafayette

International Classification:

C07K 9/00

US Classification:

514 172, 530322

Abstract:

This invention relates to collagen-binding synthetic peptidoglycans. More particularly, this invention relates to collagen-binding synthetic peptidoglycans for use in vascular intervention procedures. The invention also relates to kits comprising such collagen-binding synthetic peptidoglycans and catheters or stents.

US Patent:

20210290726, Sep 23, 2021

Filed:

Jul 9, 2018

Appl. No.:

16/629183

Inventors:

- Emeryville CA, US
Glenn Prestwich - San Francisco CA, US
Katherine Allison Stuart - San Francisco CA, US
Harsha Kabra - San Francisco CA, US
Elvis Ikwa - Palo Alto CA, US

International Classification:

A61K 38/16
A61K 38/10
A61K 38/08
A61K 47/61
A61K 47/64

Abstract:

Provided herein are synthetic bioconjugates comprising collagen-binding peptides covalently bound to chemically modified glycan backbones, compositions containing the same, and uses thereof.

US Patent:

20190022175, Jan 24, 2019

Filed:

Dec 18, 2017

Appl. No.:

15/845955

Inventors:

- West Lafayette IN, US
John Eric Paderi - San Francisco CA, US
Shaili Sharma - West Lafayette CA, US
Katherine Allison Stuart - San Francisco CA, US

International Classification:

A61K 38/14
C07K 14/47
A61K 47/61
C07K 9/00
A61K 47/54

Abstract:

This disclosure provides extracellular matrix-binding synthetic peptidoglycans comprised of one or more synthetic peptides conjugated to a glycan and methods of their use.

US Patent:

20170368192, Dec 28, 2017

Filed:

Oct 13, 2015

Appl. No.:

15/518720

Inventors:

- Emeryville CA, US
Katherine Allison Stuart - San Francisco CA, US
Alyssa Panitch - Davis CA, US
Nathan Bachtell - San Francisco CA, US
Kenneth Horne - Emeryville CA, US

International Classification:

A61K 47/64
A61K 9/08
A61K 31/726
A61L 27/50
A61L 27/34
A61L 33/12
A61F 2/06
A61L 27/54
A61L 33/00
A61K 31/727

Abstract:

This disclosure provides a method for improving maturation of an arteriovenous fistula (AVF) in a patient in need of hemodialysis, which method entails applying a solution to the internal wall of a lumen of an AVF; and restoring or initiating blood flow in the AVF, wherein the solution comprises an effective amount of a synthetic proteoglycan comprises a glycan having from about 1 to about 80 collagen-binding peptide(s) bonded to the glycan. Also provided are methods for preparing a vascular graft for a bypass surgery, comprising contacting the internal wall of a section of a blood vessel with a solution comprising an effective amount of the synthetic proteoglycan.

US Patent:

20170275345, Sep 28, 2017

Filed:

Dec 5, 2016

Appl. No.:

15/369489

Inventors:

- West Lafayette IN, US
John Eric Paderi - San Francisco CA, US
Kinam Park - West Lafayette IN, US
Katherine Allison Stuart - San Francisco CA, US
Steve Higbee - West Lafayette IN, US

International Classification:

C07K 14/47
A61L 27/22
A61L 27/24
A61L 27/38
A61L 27/54
C07K 14/00
C07K 14/78
C07K 9/00
A61K 38/00

Abstract:

This invention relates to collagen-binding synthetic peptidoglycans and engineered collagen matrices comprising a collagen matrix and a collagen-binding synthetic peptidoglycan where the collagen-binding synthetic peptidoglycan can be aberrant or can have amino acid homology with a portion of the amino acid sequence of a protein or a proteoglycan that regulates collagen fibrillogenesis. The invention also relates to kits, compounds, compositions, and engineered graft constructs comprising such collagen-binding synthetic peptidoglycans or engineered collagen matrices and methods for their preparation and use.

US Patent:

20170112941, Apr 27, 2017

Filed:

Oct 12, 2016

Appl. No.:

15/292009

Inventors:

- Emeryville CA, US
John Eric Paderi - San Francisco CA, US
Katherine Allison Stuart - San Francisco CA, US
Seema Kantak - Pacifica CA, US
Nathan Bachtell - San Francisco CA, US

International Classification:

A61K 38/00
A61K 31/728
A61K 31/727
A61K 31/737

Abstract:

This disclosure provides bioconjugate comprising a glycan and at least one peptide comprising a VE-Cadherin binding unit conjugated thereto, compositions comprising the same, and methods of use thereof.

US Patent:

20160129076, May 12, 2016

Filed:

Nov 13, 2015

Appl. No.:

14/940990

Inventors:

- San Francisco CA, US
John Eric Paderi - San Francisco CA, US
Shaili Sharma - West Lafayette IN, US
Katherine Allison Stuart - San Francisco CA, US

International Classification:

A61K 38/14
A61K 47/48

Abstract:

This disclosure provides extracellular matrix-binding synthetic peptidoglycans comprised of one or more synthetic peptides conjugated to a glycan and methods of their use.

US Patent:

20150031619, Jan 29, 2015

Filed:

Aug 22, 2014

Appl. No.:

14/466889

Inventors:

- San Francisco CA, US
John E. Paderi - San Francisco CA, US
Kinam Park - West Lafayette IN, US
Katherine Stuart - San Francisco CA, US
Steve Higbee - Lafayette IN, US

International Classification:

C07K 9/00
C07K 14/00

US Classification:

514 138, 514 209, 530322

Abstract:

This invention relates to collagen-binding synthetic peptidoglycans and engineered collagen matrices comprising a collagen matrix and a collagen-binding synthetic peptidoglycan where the collagen-binding synthetic peptidoglycan can be aberrant or can have amino acid homology with a portion of the amino acid sequence of a protein or a proteoglycan that regulates collagen fibrillogenesis. The invention also relates to kits, compounds, compositions, and engineered graft constructs comprising such collagen-binding synthetic peptidoglycans or engineered collagen matrices and methods for their preparation and use.