Wilmington Health 1202 Medical Ctr Dr, Wilmington, NC 28401 (910)3413300 (phone), (910)7721372 (fax)
Languages:
English Spanish
Description:
Ms. Monroe works in Wilmington, NC and specializes in Cardiovascular Disease. Ms. Monroe is affiliated with New Hanover Regional Medical Center and New Hanover Regional Medical Center Orthopedic Hospital.
Us Patents
Methods For Treating Dysregulated Lipid Metabolism
- South San Francisco CA, US Gilbert DI PAOLO - South San Francisco CA, US Kai Lin LIN - South San Francisco CA, US Kathryn M. MONROE - South San Francisco CA, US Alicia A. NUGENT - South San Francisco CA, US Bettina VAN LENGERICH - South San Francisco CA, US
Assignee:
DENALI THERAPEUTICS INC. - South San Francisco CA
International Classification:
C07K 16/28 A61P 3/00
Abstract:
Certain embodiments described herein provide a method for treating dysregulated lipid metabolism and/or inflammation in a mammal in need thereof, comprising administering to the mammal an effective amount of an agonist anti-triggering receptor expressed on myeloid cells 2 (TREM2) antibody.
- South San Francisco CA, US Todd P. Logan - South San Francisco CA, US Kathryn M. Monroe - South San Francisco CA, US Ankita Srivastava - South San Francisco CA, US Bettina Van Lengerich - South San Francisco CA, US
Assignee:
Denali Therapeutics Inc. - South San Francisco CA
International Classification:
C07K 14/475
Abstract:
Provided herein are fusion proteins that comprise progranulin and an Fc polypeptide. Methods of using such proteins to treat progranulin-associated disorders (e.g., a neurodegenerative disease, such as frontotemporal dementia (FTD)) are also provided herein.
- South San Francisco CA, US Zhenyu Gu - South San Francisco CA, US Mihalis S. Kariolis - South San Francisco CA, US Cathal S. Mahon - South San Francisco CA, US Kathryn M. Monroe - South San Francisco CA, US Joshua I. Park - South San Francisco CA, US Rachel Prorok - South San Francisco CA, US Adam P. Silverman - South San Francisco CA, US Bettina Van Lengerich - South San Francisco CA, US
Assignee:
Denali Therapeutics Inc. - South San Francisco CA
International Classification:
C07K 16/28
Abstract:
In one aspect, antibodies that specifically bind to a human triggering receptor expressed on myeloid cells 2 (TREM2) protein are provided. In some embodiments, the antibody decreases levels of soluble TREM2 (sTREM2). In some embodiments, the antibody enhances TREM2 activity.