Lan Wu from Rockville, MD, age 36

Us Patents

Vaccines Against Aids Comprising Cmv/R-Nucleic Acid Constructs
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US Patent:

20090214588, Aug 27, 2009
Filed:

Jul 15, 2005
Appl. No.:

11/632522
Inventors:

Gary J. Nabel - Washington DC, US
Yue Huang - Silver Spring MD, US
Zengguang Wang - Silver Spring MD, US
Ling Xu - Potomoc MD, US
Bimal Chakrabarti - Ann Arbor MI, US
Lan Wu - Bethesda MD, US
Zhi-yong Yang - Potomac MD, US
Jason G.D. Gall - Germantown MD, US
C. Richter King - Gaithersburg MD, US
International Classification:

A61K 39/21
C12N 15/11
C07K 14/00
US Classification:

4241991, 4242081, 536 2372, 530350
Abstract:

The present disclosure provides compositions for eliciting an immune response, including a prophylactic immune response, against human immunodeficiency virus. The composition includes nucleic acid constructs encoding HIV antigenic polypeptides of multiple clades or strains. Methods for eliciting an immune response by administering the composition to a subject are also provided.

Avian Influenza Vaccine
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US Patent:

20100074916, Mar 25, 2010
Filed:

Oct 10, 2007
Appl. No.:

12/443964
Inventors:

Gary J. Nabel - Washington DC, US
Zhi-yong Yang - Potomac MD, US
Chih-jen Wei - Gaithersburg MD, US
Wing-pui Kong - Germantown MD, US
Lan Wu - Washington DC, US
Assignee:

Government of the United States of America, as represented by the Secretary, Dept. of Health and - Rockville MD
International Classification:

A61K 39/145
C07K 14/005
C07K 16/00
C07H 21/04
C07H 21/02
C12P 21/00
US Classification:

4241891, 530350, 5303879, 536 2372, 435 691
Abstract:

H5 hemagglutinin (HA) polypeptides are provided that are adapted to humans through mutations that change receptor specificity in the H1 serotype, and related polynucleotides, methods, compositions, and vaccines.

Method For Improving The Breadth Of The Immune Response To Diverse Strains And Clades Of Hiv
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US Patent:

20110200636, Aug 18, 2011
Filed:

Jan 20, 2011
Appl. No.:

13/010141
Inventors:

Gary J. Nabel - Washington DC, US
Yue Huang - Silver Spring MD, US
Zengguang Wang - Silver Spring MD, US
Ling Xu - Potomac MD, US
Bimal Chakrabarti - Ann Arbor MI, US
Lan Wu - Bethesda MD, US
Zhi-yong Yang - Potomac MD, US
Jason G.D. Gall - Germantown MD, US
C. Richter King - New York NY, US
Assignee:

The USA, as represented by the Secretary, Dept. of Health and Human Services - Bethesda MD
GenVec, Inc. - Gaithersburg MD
International Classification:

A61K 39/21
A61P 31/18
US Classification:

4242081
Abstract:

The present disclosure provides compositions for eliciting an immune response, including a prophylactic immune response, against human immunodeficiency virus. The composition includes nucleic acid constructs encoding HIV antigenic polypeptides of multiple clades or strains. Methods for eliciting an immune response by administering the composition to a subject are also provided.

Trispecific Binding Proteins, Methods, And Uses Thereof
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US Patent:

20200399369, Dec 24, 2020
Filed:

Apr 8, 2020
Appl. No.:

16/843792
Inventors:

- Paris, FR
- Rockville MD, US
Jochen BENINGA - Frankfurt Am Main, DE
Joerg BIRKENFELD - Frankfurt Am Main, DE
Mark CONNORS - Rockville MD, US
Richard A. KOUP - Washington DC, US
Young Do KWON - Bethesda MD, US
Peter D. KWONG - Bethesda MD, US
Qingbo LIU - Rockville MD, US
Paolo LUSSO - Rockville MD, US
John R. MASCOLA - Rockville MD, US
Gary J. NABEL - Bridgewater NJ, US
Amarendra PEGU - Rockville MD, US
Huawei QIU - Westborough MA, US
Ercole RAO - Morfelden-Walldorf, DE
Joerg REGULA - Munich, DE
Edward SEUNG - Bridgewater NJ, US
Ronnie WEI - Needman MA, US
Lan WU - Bridgewater NJ, US
Zhen XING - Bridgewater NJ, US
Ling XU - Bridgewater NJ, US
Zhi-Yong YANG - Bridgewater NJ, US
Béatrice Cameron - Paris, FR
Tarik Dabdoubi - Paris, FR
Cendrine Lemoine - Paris, FR
Catherine Prades - Paris, FR
International Classification:

C07K 16/28
C07K 16/32
A61K 45/06
A61K 39/395
Abstract:

Provided herein are trispecific and/or trivalent binding proteins comprising four polypeptide chains that form three antigen binding sites that specifically bind one or more target proteins, wherein a first pair of polypeptides forming the binding protein possess dual variable domains having a cross-over orientation, and wherein and a second pair of polypeptides possess a single variable domain forming a single antigen binding site. In some embodiments, the binding proteins comprise a binding site that binds a CD28 polypeptide, a binding site that binds a CD3 polypeptide, and a binding site that binds a third polypeptide, such as a tumor target protein. In some embodiments, the binding proteins comprise four polypeptide chains that form three antigen binding sites that specifically bind one or more HIV target proteins. The disclosure also relates to methods for making trispecific and/or trivalent binding proteins and uses of such binding proteins.