Lan Wu

US Patent:

20210061925, Mar 4, 2021

Filed:

Nov 16, 2020

Appl. No.:

17/099439

Inventors:

- Paris, FR
Gary J. NABEL - Bridgewater NJ, US
Lan WU - Bridgewater NJ, US
Edward SEUNG - Bridgewater NJ, US
Ronnie WEI - Needham MA, US
Jochen BENINGA - Frankfurt am Main, DE
Ercole RAO - Frankfurt am Main, DE
Wulf Dirk LEUSCHNER - Frankfurt am Main, DE
Christian BEIL - Frankfurt am Main, DE
Christian LANGE - Frankfurt am Main, DE
Carsten CORVEY - Frankfurt am Main, DE

International Classification:

C07K 16/46
C07K 16/24
C07K 16/28
C07K 16/32
A61K 39/395
A61K 45/06
C07K 1/22

Abstract:

The disclosure provides trispecific and/or trivalent binding proteins comprising four polypeptide chains that form three antigen binding sites that specifically bind one or more target proteins, wherein a first pair of polypeptides forming the binding protein possess dual variable domains having a cross-over orientation and wherein a second pair of polypeptides forming the binding protein possess a single variable domain. The disclosure also provides methods for making trispecific and/or trivalent binding proteins and uses of such binding proteins.

US Patent:

20200399369, Dec 24, 2020

Filed:

Apr 8, 2020

Appl. No.:

16/843792

Inventors:

- Paris, FR
- Rockville MD, US
Jochen BENINGA - Frankfurt Am Main, DE
Joerg BIRKENFELD - Frankfurt Am Main, DE
Mark CONNORS - Rockville MD, US
Richard A. KOUP - Washington DC, US
Young Do KWON - Bethesda MD, US
Peter D. KWONG - Bethesda MD, US
Qingbo LIU - Rockville MD, US
Paolo LUSSO - Rockville MD, US
John R. MASCOLA - Rockville MD, US
Gary J. NABEL - Bridgewater NJ, US
Amarendra PEGU - Rockville MD, US
Huawei QIU - Westborough MA, US
Ercole RAO - Morfelden-Walldorf, DE
Joerg REGULA - Munich, DE
Edward SEUNG - Bridgewater NJ, US
Ronnie WEI - Needman MA, US
Lan WU - Bridgewater NJ, US
Zhen XING - Bridgewater NJ, US
Ling XU - Bridgewater NJ, US
Zhi-Yong YANG - Bridgewater NJ, US
Béatrice Cameron - Paris, FR
Tarik Dabdoubi - Paris, FR
Cendrine Lemoine - Paris, FR
Catherine Prades - Paris, FR

International Classification:

C07K 16/28
C07K 16/32
A61K 45/06
A61K 39/395

Abstract:

Provided herein are trispecific and/or trivalent binding proteins comprising four polypeptide chains that form three antigen binding sites that specifically bind one or more target proteins, wherein a first pair of polypeptides forming the binding protein possess dual variable domains having a cross-over orientation, and wherein and a second pair of polypeptides possess a single variable domain forming a single antigen binding site. In some embodiments, the binding proteins comprise a binding site that binds a CD28 polypeptide, a binding site that binds a CD3 polypeptide, and a binding site that binds a third polypeptide, such as a tumor target protein. In some embodiments, the binding proteins comprise four polypeptide chains that form three antigen binding sites that specifically bind one or more HIV target proteins. The disclosure also relates to methods for making trispecific and/or trivalent binding proteins and uses of such binding proteins.

US Patent:

20170320967, Nov 9, 2017

Filed:

Apr 13, 2017

Appl. No.:

15/487243

Inventors:

- Paris, FR
Gary J. NABEL - Bridgewater NJ, US
Lan WU - Bridgewater NJ, US
Edward SEUNG - Bridgewater NJ, US
Ronnie WEI - Bridgewater NJ, US
Jochen BENINGA - Frankfurt am Main, DE
Ercole RAO - Frankfurt am Main, DE
Wulf Dirk LEUSCHNER - Frankfurt am Main, DE
Christian BEIL - Frankfurt am Main, DE
Christian LANGE - Frankfurt am Main, DE
Carsten CORVEY - Frankfurt am Main, DE

International Classification:

C07K 16/46
A61K 39/395
A61K 45/06
C07K 1/22
C07K 16/24
C07K 16/24
C07K 16/28
C07K 16/32
C07K 16/28
A61K 39/395
C07K 16/28
C07K 16/24
A61K 39/00

Abstract:

The disclosure provides trispecific and/or trivalent binding proteins comprising four polypeptide chains that form three antigen binding sites that specifically bind one or more target proteins, wherein a first pair of polypeptides forming the binding protein possess dual variable domains having a cross-over orientation and wherein a second pair of polypeptides forming the binding protein possess a single variable domain. The disclosure also provides methods for making trispecific and/or trivalent binding proteins and uses of such binding proteins.