Li Chen

US Patent:

6445734, Sep 3, 2002

Filed:

Jun 30, 1999

Appl. No.:

09/343873

Inventors:

Li Chen - Irvine CA
Farhad Aminian - Irvine CA
Keith T. Chu - Laguna Niguel CA

Assignee:

Conexant Systems, Inc. - Newport Beach CA

International Classification:

H03H 730

US Classification:

375231, 375232, 375350, 708305, 708323

Abstract:

Equalizer training is validated by techniques to detect false training. The validation techniques involve checking the unique time domain energy shaping of a plurality of taps of a trained equalizer of a modem for good training. The energy measure for each equalizer tap of the plurality of taps is approximated by summing the magnitude of a real component and a magnitude of an imaginary component of an equalizer coefficient corresponding to the equalizer tap. A tap with a highest approximate energy (i. e. , the main tap) is then determined. Next, the main tap energy is compared to a main tap threshold and a predetermined guarding threshold. The plurality of taps are arranged in a time index ordered sequence. In determining the main tap threshold, a first energy sum of a beginning set of taps in the sequence is compared with a second energy sum of a last set of taps in the sequence. The lesser tap energy sum between the first energy sum and the second energy sum is the main tap threshold.

US Patent:

6455550, Sep 24, 2002

Filed:

Aug 21, 1998

Appl. No.:

09/138353

Inventors:

Li Chen - Westfield NJ
Robert William Guthrie - Saddle Brook NJ
Jefferson Wright Tilley - North Caldwell NJ
Kenneth Gregory Hull - Cambridge MA

Assignee:

Hoffmann-La Roche Inc. - Nutley NJ

International Classification:

A61K 314166

US Classification:

514341, 514386, 5462744, 5483225, 5483255

Abstract:

Compounds of the formula: are disclosed which have activity as inhibitors of binding between VCAM-1 and cells expressing VLA-4. Such compounds are useful for treating diseases whose symptoms and/or damage are related to the binding of VCAM-1 to cells expressing VLA-4.

US Patent:

6600015, Jul 29, 2003

Filed:

Mar 19, 2001

Appl. No.:

09/811964

Inventors:

Li Chen - Westfield NJ
Adrian Wai-Hing Cheung - Glen Rock NJ
Waleed Danho - Wayne NJ
Joseph Swistok - Nutley NJ
Keith Alan Yagaloff - HoHokus NJ

Assignee:

Hoffmann-La Roche Inc. - Nutley NJ

International Classification:

C07K 508

US Classification:

530331, 530330, 514 18

Abstract:

Peptides that selectively stimulate melanocortin-4 (MC-4) receptor activity are disclosed. In one embodiment, the peptides are of formula I:.

US Patent:

6756374, Jun 29, 2004

Filed:

Jan 9, 2002

Appl. No.:

10/042619

Inventors:

Li Chen - Westfield NJ
Qingjie Ding - Bridgewater NJ
Paul Gillespie - Westfield NJ
Kyungjin Kim - Livingston NJ
Allen John Lovey - North Caldwell NJ
Warren William McComas - Denville NJ
Agostino Perrotta - Bloomfield NJ

Assignee:

Hoffmann-La Roche Inc. - Nutley NJ

International Classification:

A61K 31496

US Classification:

5142358, 5142531, 51425402, 544121, 544304, 544367

Abstract:

Disclosed are novel diaminothiazoles of formula wherein R , R , R , R and R are as herein disclosed. These compounds and their pharmaceutically acceptable salts and esters are selective inhibitors of Cdk4. As such, these compounds and their pharmaceutically acceptable salts and esters are anti-proliferative agents useful in the treatment or control of solid tumors, in particular breast, colon, lung and prostate tumors. Also disclosed are pharmaceutical compositions containing the compounds of formula I and their pharmaceutically acceptable salts and esters, as well as intermediates useful in the preparation of the compounds of formula I.

US Patent:

6806365, Oct 19, 2004

Filed:

Apr 5, 2002

Appl. No.:

10/117616

Inventors:

Li Chen - Westfield NJ
Robert William Guthrie - Saddle Brook NJ
Jefferson Wright Tilley - North Caldwell NJ
Kenneth Gregory Hull - Cambridge MA

Assignee:

Hoffmann-La Rocher Inc. - Nutley NJ

International Classification:

C07C22902

US Classification:

544169, 546323, 548214, 548253, 5483741, 548536, 549436, 552 10, 558406, 558415, 560 30, 562426, 562429, 562430, 562435, 562441, 562448, 562449

Abstract:

Compounds of the formula: are disclosed which have activity as inhibitors of binding between VCAM-1 and cells expressing VLA-4. Such compounds are useful for treating diseases whose symptoms and/or damage are related to the binding of VCAM-1 to cells expressing VLA-4.

US Patent:

7043777, May 16, 2006

Filed:

Sep 27, 2002

Appl. No.:

10/433283

Inventors:

Mark S. Bloom - Mission Viejo CA, US
Alston E. Williams - Irvine CA, US
Li Chen - Brea CA, US

Assignee:

Newfrey LLC - Newark DE

International Classification:

E03C 1/042

US Classification:

4695, 249177, 2851242, 2851391

Abstract:

A single control roman tub faucet () includes a lower anchor () that is attached to the roughed-in tub surround () and an upper anchor () that is installed on the final decorative surface of the tub surround. The upper anchor is attached to the lower anchor by a fastener () that extends therebetween. Outlet pipes () extend through the lower and upper anchors and connect water supply lines to the faucet.

US Patent:

7045591, May 16, 2006

Filed:

Aug 27, 2001

Appl. No.:

09/939966

Inventors:

Li Chen - Westfield NJ, US
Adrian Wai-Hing Cheung - Glen Rock NJ, US
Waleed Danho - Wayne NJ, US
Joseph Swistok - Nutley NJ, US
Yao Wang - Edison NJ, US
Keith Alan Yagaloff - Broad Brook CT, US

Assignee:

Hoffmann-La Roche Inc. - Nutley NJ

International Classification:

C07K 7/50

US Classification:

530317, 514 11, 514 17, 530318, 530328, 530330

Abstract:

Peptides cyclized via disulfide or lactam bridges are disclosed. The peptides exhibit melanocortin-4 receptor agonist activity and are useful for treating obesity.

US Patent:

7654672, Feb 2, 2010

Filed:

Oct 31, 2008

Appl. No.:

12/263433

Inventors:

Huawei Zhao - Irvine CA, US
Li Chen - Santa Clara CA, US

Assignee:

Abbott Medical Optics Inc. - Santa Ana CA

International Classification:

A61B 3/10

US Classification:

351221, 351205

Abstract:

A system for providing vision contains an aberrometer, a wavefront sensor, and a transfer optical system. The aberrometer is configured to measure a received wavefront. The aberrometer includes a wavefront sensor and a transfer optical system for transferring an input wavefront so as to the provide the received wavefront at or near the wavefront sensor. The system also includes a processor in communication with the aberrometer, a readable memory, and instructions located within the memory. The readable memory contains one or more system error parameters and instructions available to the processor. The instructions are for determining at least one aberration of the received wavefront and calculating the input wavefront based on the received wavefront and the one or more system error parameters.