Methods of treating chronic heart failure (CHF) by increasing the high energy phosphate concentrations available to heart muscle by administering a xanthine oxidase inhibitor to a patient having CHF are provided. As a result of such therapy, contractility of the heart is improved.
Christopher Lademacher - Evanston IL, US Lin Zhao - Vernon Hills IL, US Richard Johnson - Gainesville FL, US
International Classification:
A61K 31/53 A61K 31/426 A61K 31/4196 A61K 31/415
US Classification:
514246000, 514365000, 514383000, 514406000
Abstract:
The present invention relates to methods of treating subjects suffering from pre-hypertension or hypertension by administering to a subject in need of treatment thereof a therapeutically effective amount of at least one xanthine oxidoreductase inhibiting compound or salt thereof.
Methods For Delaying The Progression Of At Least One Of Cardiac Hypertrophy, Cardiac Remodeling Or Left Ventricular Function Or The Onset Of Heart Failure In Subjects In Need Of Treatment Thereof
The present invention relates to methods for reducing the progression of at least one of cardiac hypertrophy, cardiac remodeling or left ventricular dysfunction following a cardiac insult in a subject in need of treatment thereof. Moreover, the present invention also relates to methods of delaying the onset of heart failure symptoms or reducing the incidence of cardiovascular events following a cardiac insult in a subject in need of treatment thereof.
Methods of treating chronic heart failure (CHF) by increasing the high energy phosphate concentrations available to heart muscle by administering a xanthine oxidase inhibitor to a patient having CHF are provided. As a result of such therapy, contractility of the heart is improved.
- Cambridge MA, US Gang Chen - Carlisle MA, US Xuanhe Zhao - Allston MA, US Elise M. Strobach - Clear Lake WI, US Bikramjit S. Bhatia - Cambridge MA, US Lin Zhao - Revere MA, US Sungwoo Yang - Chattanooga TN, US Lee A. Weinstein - Somerville MA, US Thomas A. Cooper - Boston MA, US Shaoting Lin - Cambridge MA, US
Recent progress in passive radiative cooling technologies have significantly improved cooling performance under direct sunlight. Performance of existing passive radiative coolers for air conditioning and portable refrigeration applications can be improved with a material that is solar reflective and infrared transparent that can also have a low thermal conductivity.
Solar Thermal Aerogel Receiver And Materials Therefor
- Cambridge MA, US Evelyn N. Wang - Cambridge MA, US Svetlana Boriskina - Winchester MA, US Lee A. Weinstein - Somerville MA, US Sungwoo Yang - Chattanooga TN, US Bikramjit S. Bhatia - Cambridge MA, US Lin Zhao - Revere MA, US Elise M. Strobach - Clear Lake WI, US Thomas A. Cooper - Boston MA, US David M. Bierman - Cambridge MA, US Xiaopeng Huang - Mountain View CA, US James Loomis - Valparaiso FL, US
A silica aerogel having a mean pore size less than 5 nm with a standard deviation of 3 nm. The silica aerogel may have greater than 95% solar-weighted transmittance at a thickness of 8 mm for wavelengths in the range of 250 nm to 2500 nm, and a 400 C. black-body weighted specific extinction coefficient of greater than 8 m/kg for wavelengths of 1.5 μm to 15 μm. Silica aerogel synthesis methods are described. A solar thermal aerogel receiver (STAR) may include an opaque frame defining an opening, an aerogel layer disposed in the opaque frame, with at least a portion of the aerogel layer being proximate the opening, and a heat transfer fluid pipe in thermal contact with and proximate the aerogel layer. A concentrating solar energy system may include a STAR and at least one reflector to direct sunlight to an opening in the STAR.
- Cambridge MA, US Gang Chen - Carlisle MA, US Xuanhe Zhao - Allston MA, US Elise M. Strobach - Clear Lake WI, US Bikramjit S. Bhatia - Cambridge MA, US Lin Zhao - Revere MA, US Sungwoo Yang - Chattanooga TN, US Lee A. Weinstein - Somerville MA, US Thomas A. Cooper - Boston MA, US Shaoting Lin - Cambridge MA, US