Lixin G Wang

US Patent:

20080280819, Nov 13, 2008

Filed:

Jun 20, 2007

Appl. No.:

11/766012

Inventors:

Million Mulugeta - Culver City CA, US
Lixin Wang - Los Angeles CA, US
Yvette Tache - Los Angeles CA, US
Jean Rivier - La Jolla CA, US

International Classification:

A61K 38/16
A61P 17/14

US Classification:

514 9

Abstract:

This disclosure reveals that cyclic corticotrophin releasing factor (CRF) antagonist peptides (such as astressin B, its functional fragments, and their derivatives) induce hair growth and prevent hair loss in vivo. This important discovery enables, for instance, methods of promoting hair growth, and methods of treating hair loss (such as the hair loss that occurs normally in some individuals or that is the result of a health disorder or therapeutic treatment). Exemplary cyclic CRF antagonist peptides useful in the disclosed methods are provided throughout the disclosure.

US Patent:

20110288101, Nov 24, 2011

Filed:

May 20, 2011

Appl. No.:

13/112827

Inventors:

Lixin Wang - Arlington TX, US
Marcia Danielle Ong - Fort Worth TX, US
Chi-Chun Tsai - Fort Worth TX, US
Michael Hartzer - Arlington TX, US

Assignee:

ALCON RESEARCH, LTD. - Fort Worth TX

International Classification:

A61K 31/439
C07C 211/28
A61K 31/137
C07C 251/58
A61P 41/00
C07D 307/14
A61K 31/341
C07D 295/096
A61K 31/495
A61P 27/02
C07D 221/26
A61K 31/15

US Classification:

51425212, 514295, 546 97, 564383, 514654, 564256, 514640, 549492, 514471, 544398

Abstract:

One aspect of the present invention relates to aqueous surgical compositions comprising a sigma-1 receptor agonist. Another aspect of the present invention relates to methods of irrigating ocular tissues during an ophthalmic surgical procedure such as cataract surgery. Such methods comprise bathing the ocular tissues with a composition comprising a sigma-1 receptor agonist.

US Patent:

20230013402, Jan 19, 2023

Filed:

Sep 4, 2020

Appl. No.:

17/634420

Inventors:

- Oakland CA, US
Akishige HOKUGO - Los Angeles CA, US
Hodaka SASAKI - Saitama, JP
Hiroko OKAWA - Los Angeles CA, US
Lixin WANG - Los Angeles CA, US
Robert D. DAMOISEAUX - Los Angeles CA, US

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

A61K 31/4745
A61K 31/357
A61K 31/44
A61K 31/5377
A61K 31/165
A61K 31/365
A61K 31/36
A61K 31/428
A61K 31/33
A61K 31/519
C12N 15/113
A61K 31/4174
A61K 31/216
A61K 31/22
A61K 31/775
A61K 31/34
A61K 31/137
A61K 31/27
A61K 31/573
A61K 31/704
A61K 31/45
A61P 17/02

Abstract:

The present invention provides methods for improving or accelerating wound healing in a subject comprising administering to a wound of the subject in need thereof an agent that suppresses expression of a clock gene, wherein the clock gene is neuronal PAS domain protein 2 (Npas2). This invention also relates to methods for regenerating alveolar bone, regenerating connective tissue at a wound site, and for decreasing wound area size comprising administering to a bone loss site or a wound site, in particular, an open wound site, of a subject an agent that suppresses expression of Npas2.