Louis J Ferrara

US Patent:

57446008, Apr 28, 1998

Filed:

Dec 16, 1994

Appl. No.:

8/357561

Inventors:

Muzammil M. Mansuri - Cheshire CT
John C. Martin - San Carlos CA
Thomas W. Hudyma - Durham CT
Joanne J. Bronson - Madison CT
Louis M. Ferrara - Meriden CT

Assignee:

Institute of Organic Chemistry and Biochemistry of the Academy of
Sciences of the Czech Republic
Rega Stichting v.z.w.

International Classification:

A61K 31675
C07F 96561
C07D47318
C07D47334

US Classification:

544243

Abstract:

A compound of the Formula I or Formula II ##STR1## wherein R. sup. 1 and R. sup. 2 are independently hydrogen, hydroxy, chlorine, fluorine, bromine, or an organic substituent having 1 to 5 carbon atoms and selected from acyloxy having a hydrocarbon stem of 1 to 4 carbon atoms, alkoxy, alkylthio, amino, alkylamino and dialkylamino; R. sup. 3 and R. sup. 4 are independently hydrogen, or organic phosphonic ester substituents having 1 to 12 carbon atoms and selected from alkyl, alkenyl, aryl, and aralkyl; and B is a heterocyclic group selected from the group consisting of pyrimidine, purine, triazine, deazapurine, and triazole, attached through a ring nitrogen atom thereof optionally substituted with 1 to 3 substituents selected from the group consisting of hydroxy, mercapto, amino, hydrazino, fluoro, chloro, bromo, iodo, C. sub. 1 to C. sub. 3 alkyl, C2-C3 alkenyl, C2-C3 haloalkenyl, C1-C3 alkoxy, and C1-C3 alkylthio; and the pharmaceutically acceptable acid addition, metal, and amine salts thereof. The compositions of the invention are useful for, among other things, antiviral agents.