Mark Wall

US Patent:

20020017977, Feb 14, 2002

Filed:

Aug 3, 2001

Appl. No.:

09/921968

Inventors:

Mark Wall - Fair Lawn NJ, US

International Classification:

G05B019/00
H04Q001/00
G05B023/00

US Classification:

340/005280, 340/005320, 340/825490

Abstract:

A method and system for controlling use of software and hardware, and for controlling access to and usability of commodities, by use of position (or location) dependent signals emanating from GPS, DPGS, GLONASS, and other sources, in conjunction with time and ephemeris data, wherein the receipt of position (or location) data is verified by reference to independent time and satellite ephemeris data, and where when position (or location) is established within preloaded boundaries, the system is rendered useful. A module which includes software and/or hardware modules (implemented as chip sets in combination with mechanical actuators), and a position (or location) determining system such as a global positioning receiver, built into each device and/or shipping container used to transport devices and/or commodities for control.

US Patent:

20210206822, Jul 8, 2021

Filed:

Feb 5, 2021

Appl. No.:

17/168325

Inventors:

- Beerse, BE
Raymond J. PATCH - Yardley PA, US
Rui ZHANG - Belle Mead NJ, US
Martin A. CASE - San Diego CA, US
Mark J. WALL - Lansdale PA, US
Yue-Mei ZHANG - Wellesley MA, US

International Classification:

C07K 14/575
A61K 47/68
C07K 16/24
A61K 9/00
A61K 38/17
A61K 38/26
C07K 1/06
C07K 1/107
A61K 47/64
A61P 3/10
A61K 49/00
C07K 1/12
C07K 1/18
C07K 5/02
A61K 47/60
A61P 3/08
A61P 3/00
A61P 3/04
A61P 3/06
A61K 38/22
A61K 45/06
C07K 16/00

Abstract:

The present invention comprises compounds of Formula I.wherein:Z, Z, Z, Z, Z, Z, Z, Z, Z, Z, p, m, n, q, and BRIDGE are defined in the specification. The invention also relates to pharmaceutical compositions and methods for use thereof. The novel compounds are useful for preventing, treating or ameliorating diseases and disorders, such as obesity, type 2 diabetes, the metabolic syndrome, insulin resistance, and dyslipidemia, among others.

US Patent:

20210163566, Jun 3, 2021

Filed:

Feb 5, 2021

Appl. No.:

17/168503

Inventors:

- Beerse, BE
Raymond J. PATCH - Yardley PA, US
Rui ZHANG - Belle Mead NJ, US
Martin A. CASE - San Diego CA, US
Shamina M. RANGWALA - Furlong PA, US
James N. LEONARD - Ambler PA, US
Raul C. CAMACHO - Philadelphia PA, US
Michael J. HUNTER - Santee CA, US
Katharine E. D'AQUINO - Perkasie PA, US
Wilson EDWARDS - Cardiff-by the-Sea CA, US
Ronald V. SWANSON - Del Mar CA, US
Wenying JIAN - Princeton NJ, US
Yue-Mei ZHANG - Wellesley MA, US
Mark J. WALL - Lansdale PA, US
Ellen CHI - San Diego CA, US

International Classification:

C07K 14/575
A61K 47/68
C07K 16/24
A61K 9/00
A61K 38/17
A61K 38/26
C07K 1/06
C07K 1/107
A61K 47/64
A61P 3/10
A61K 49/00
C07K 1/12
C07K 1/18
C07K 5/02
A61K 47/60
A61P 3/08
A61P 3/00
A61P 3/04
A61P 3/06
A61K 38/22
A61K 45/06
C07K 16/00

Abstract:

The present invention comprises conjugates comprising a monoclonal antibody conjugated to a cyclic PYY peptide. The invention also relates to pharmaceutical compositions and methods for use thereof. The novel conjugates are useful for preventing, treating or ameliorating diseases and disorders disclosed herein.

US Patent:

20210094998, Apr 1, 2021

Filed:

Oct 30, 2020

Appl. No.:

17/085128

Inventors:

- Beerse, BE
Raymond J. PATCH - Yardley PA, US
Rui ZHANG - Belle Mead NJ, US
Martin A. CASE - San Diego CA, US
Mark J. WALL - Lansdale PA, US
Yue-Mei ZHANG - Wellesley MA, US
Shamina M. RANGWALA - Furlong PA, US
James N. LEONARD - Ambler PA, US
Raul C. CAMACHO - Philadelphia PA, US
Michael J. HUNTER - Santee CA, US
Katharine E. D'AQUINO - Perkasie PA, US
Wilson EDWARDS - Cardiff-by the-Sea CA, US
Ronald V. SWANSON - Del Mar CA, US
Wenying JIAN - Princeton NJ, US
Ellen CHI - San Diego CA, US

International Classification:

C07K 14/575
A61K 47/68
C07K 16/24
A61K 9/00
A61K 38/17
A61K 38/26
C07K 1/06
C07K 1/107
A61K 47/64
A61P 3/10
A61K 49/00
C07K 1/12
C07K 1/18
C07K 5/02
A61K 47/60
A61P 3/08
A61P 3/00
A61P 3/04
A61P 3/06
A61K 38/22
A61K 45/06
C07K 16/00

Abstract:

The present invention relates to a monoclonal antibody platform designed to be coupled to therapeutic peptides to increase the half-life of the therapeutic peptide in a subject. The invention also relates to pharmaceutical compositions and methods for use thereof.

US Patent:

20200385439, Dec 10, 2020

Filed:

Aug 21, 2020

Appl. No.:

16/947875

Inventors:

- Beerse, BE
Raymond J. Patch - Yardley PA, US
Rui Zhang - Belle Mead NJ, US
Martin A. Case - San Diego CA, US
Shamina M. Rangwala - Furlong PA, US
James N. Leonard - Ambler PA, US
Raul C. Camacho - Philadelphia PA, US
Michael J. Hunter - Santee CA, US
Katharine E. D'Aquino - Perkasie PA, US
Wilson Edwards - Cardiff-by the-Sea CA, US
Ronald V. Swanson - Del Mar CA, US
Wenying Jian - Princeton NJ, US
Yue-Mei Zhang - Wellesley MA, US
Mark J. Wall - Lansdale PA, US
Ellen Chi - San Diego CA, US

International Classification:

C07K 14/575
A61K 47/68
C07K 16/24
A61K 9/00
A61K 38/17
A61K 38/26
C07K 1/06
C07K 1/107
A61K 47/64
A61P 3/10
A61K 49/00
C07K 1/12
C07K 1/18
C07K 5/02
A61K 47/60
A61P 3/08
A61P 3/00
A61P 3/04
A61P 3/06
A61K 38/22
A61K 45/06
C07K 16/00

Abstract:

The present invention relates to a monoclonal antibody platform designed to be coupled to therapeutic peptides to increase the half-life of the therapeutic peptide in a subject. The invention also relates to pharmaceutical compositions and methods for use thereof.

US Patent:

20200283491, Sep 10, 2020

Filed:

Mar 16, 2020

Appl. No.:

16/820174

Inventors:

- Beerse, BE
Raymond J. PATCH - Yardley PA, US
Rui ZHANG - Belle Mead NJ, US
Martin A. CASE - San Diego CA, US
Shamina M. RANGWALA - Furlong PA, US
James N. LEONARD - Ambler PA, US
Raul C. CAMACHO - Philadelphia PA, US
Michael J. HUNTER - Santee CA, US
Katharine E. D'AQUINO - Perkasie PA, US
Wilson EDWARDS - Cardiff-by the-Sea CA, US
Ronald V. SWANSON - Del Mar CA, US
Wenying JIAN - Princeton NJ, US
Yue-Mei ZHANG - Wellesley MA, US
Mark J. WALL - Lansdale PA, US
Ellen CHI - San Diego CA, US

International Classification:

C07K 14/575
A61K 47/68
C07K 16/24
A61K 9/00
A61K 38/17
A61K 38/26
C07K 1/06
C07K 1/107
A61K 47/64
A61P 3/10
A61K 49/00
C07K 1/12
C07K 1/18
C07K 5/02
A61K 47/60
A61P 3/08
A61P 3/00
A61P 3/04
A61P 3/06
A61K 38/22
A61K 45/06
C07K 16/00

Abstract:

The present invention comprises conjugates comprising a monoclonal antibody conjugated to a cyclic PYY peptide. The invention also relates to pharmaceutical compositions and methods for use thereof. The novel conjugates are useful for preventing, treating or ameliorating diseases and disorders disclosed herein.

US Patent:

20190367577, Dec 5, 2019

Filed:

Aug 16, 2019

Appl. No.:

16/542751

Inventors:

- Beerse, BE
Raymond J. PATCH - Yardley PA, US
Rui ZHANG - Belle Mead NJ, US
Martin A. CASE - San Diego CA, US
Shamina M. RANGWALA - Furlong PA, US
James N. LEONARD - Ambler PA, US
Raul C. CAMACHO - Philadelphia PA, US
Michael J. HUNTER - Santee CA, US
Katharine E. D'AQUINO - Perkasie PA, US
Wilson EDWARDS - Cardiff-by the-Sea CA, US
Ronald V. SWANSON - Del Mar CA, US
Wenying JIAN - Princeton NJ, US
Yue-Mei ZHANG - Wellesley MA, US
Mark J. WALL - Lansdale PA, US
Ellen CHI - San Diego CA, US

International Classification:

C07K 14/575
A61K 47/64
A61P 3/10
A61K 38/17
A61K 49/00
C07K 1/12
C07K 1/18
C07K 5/02
A61K 47/60
A61P 3/08
A61P 3/00
A61P 3/04
A61P 3/06
A61K 38/22
A61K 45/06
A61K 47/68
C07K 16/00

Abstract:

The present invention relates to a monoclonal antibody platform designed to be coupled to therapeutic peptides to increase the half-life of the therapeutic peptide in a subject. The invention also relates to pharmaceutical compositions and methods for use thereof.

US Patent:

20190345214, Nov 14, 2019

Filed:

Oct 26, 2017

Appl. No.:

16/344141

Inventors:

- Beerse, BE
Raymond J. PATCH - Yardley PA, US
Rui ZHANG - Belle Mead NJ, US
Martin A. CASE - San Diego CA, US
Mark J. WALL - Lansdale PA, US
Yue-Mei ZHANG - Wellesley MA, US

International Classification:

C07K 14/575
A61K 45/06
A61K 47/64
A61K 47/68
A61P 3/04
C07K 1/06
C07K 1/107

Abstract:

The present invention comprises compounds of Formula I.wherein: