Mark H Wall

US Patent:

7391509, Jun 24, 2008

Filed:

Feb 2, 2006

Appl. No.:

11/345764

Inventors:

Francis J. Deck - Madison WI, US
Mark H. Wall - Madison WI, US
Joe Hodkiewicz - Madison WI, US

Assignee:

Thermo Electron Scientific Instruments LLC - Madison WI

International Classification:

G01B 9/02

US Classification:

356 73

Abstract:

An analytical microscope provides both UV fluorescence imaging and spectroscopic analysis of a sample with use of the same light collection element (objective lens or other optical element). An incident UV light beam travels to the sample via a dark field illumination path about the periphery of the collection lens, with the collection lens then collecting the emitted light from the sample and forwarding it to an eyepiece and/or camera for viewing. The sample is also illuminated with a laser through the collection lens to generate Raman emissions, which are then collected through the same collection lens and provided to a spectrograph for wavelength identification. Use of the same collection lens for both imaging and spectroscopic analysis better ensures that any imaged regions of interest on the sample are the same as those being spectroscopically analyzed.

US Patent:

20020017977, Feb 14, 2002

Filed:

Aug 3, 2001

Appl. No.:

09/921968

Inventors:

Mark Wall - Fair Lawn NJ, US

International Classification:

G05B019/00
H04Q001/00
G05B023/00

US Classification:

340/005280, 340/005320, 340/825490

Abstract:

A method and system for controlling use of software and hardware, and for controlling access to and usability of commodities, by use of position (or location) dependent signals emanating from GPS, DPGS, GLONASS, and other sources, in conjunction with time and ephemeris data, wherein the receipt of position (or location) data is verified by reference to independent time and satellite ephemeris data, and where when position (or location) is established within preloaded boundaries, the system is rendered useful. A module which includes software and/or hardware modules (implemented as chip sets in combination with mechanical actuators), and a position (or location) determining system such as a global positioning receiver, built into each device and/or shipping container used to transport devices and/or commodities for control.

US Patent:

20130011887, Jan 10, 2013

Filed:

Oct 8, 2010

Appl. No.:

13/502105

Inventors:

Christopher L.G. Dayton - Mount Kisco NY, US
Flavio Da Silva Galhardo - Scarsdale NY, US
Nelson Barton - San Diego CA, US
Tim Hitchman - Carlsbad CA, US
Jonathan Lyon - San Diego CA, US
Eileen O'Donoghue - San Diego CA, US
Mark A. Wall - San Diego CA, US

International Classification:

C11B 3/02
A23D 7/02
C09K 3/00
A23D 7/00
C12P 9/00
C11C 1/08

US Classification:

435131, 435271, 2521823, 426602, 426 33

Abstract:

In alternative embodiments, the invention provides phosphatidylinositol-specific phospholipase C (PI-PLC) enzymes, nucleic acids encoding them, antibodies that bind specifically to them, and methods for making and using them. Industrial methods and products comprising use of these phospholipases are also provided. In certain embodiments, provided herein are methods for hydration of non hydratable phospholipids (NHPs) within a lipid matrix. The methods enable migration of NHPs to an oil-water interface thereby allowing the NHPs to be reacted and/or removed from the lipids. In certain embodiments, provided is a method for removing NHPs, hydratable phospholipids, and lecithins from vegetable oils to produce a degummed oil or fat product that can be used for food production and/or non-food applications. In certain embodiments, provided herein are methods for hydration of NHPs followed by enzymatic treatment and removal of various phospholipids and lecithins. The methods provided herein can be practiced on either crude or water-degummed oils.

US Patent:

20210206822, Jul 8, 2021

Filed:

Feb 5, 2021

Appl. No.:

17/168325

Inventors:

- Beerse, BE
Raymond J. PATCH - Yardley PA, US
Rui ZHANG - Belle Mead NJ, US
Martin A. CASE - San Diego CA, US
Mark J. WALL - Lansdale PA, US
Yue-Mei ZHANG - Wellesley MA, US

International Classification:

C07K 14/575
A61K 47/68
C07K 16/24
A61K 9/00
A61K 38/17
A61K 38/26
C07K 1/06
C07K 1/107
A61K 47/64
A61P 3/10
A61K 49/00
C07K 1/12
C07K 1/18
C07K 5/02
A61K 47/60
A61P 3/08
A61P 3/00
A61P 3/04
A61P 3/06
A61K 38/22
A61K 45/06
C07K 16/00

Abstract:

The present invention comprises compounds of Formula I.wherein:Z, Z, Z, Z, Z, Z, Z, Z, Z, Z, p, m, n, q, and BRIDGE are defined in the specification. The invention also relates to pharmaceutical compositions and methods for use thereof. The novel compounds are useful for preventing, treating or ameliorating diseases and disorders, such as obesity, type 2 diabetes, the metabolic syndrome, insulin resistance, and dyslipidemia, among others.

US Patent:

20210163566, Jun 3, 2021

Filed:

Feb 5, 2021

Appl. No.:

17/168503

Inventors:

- Beerse, BE
Raymond J. PATCH - Yardley PA, US
Rui ZHANG - Belle Mead NJ, US
Martin A. CASE - San Diego CA, US
Shamina M. RANGWALA - Furlong PA, US
James N. LEONARD - Ambler PA, US
Raul C. CAMACHO - Philadelphia PA, US
Michael J. HUNTER - Santee CA, US
Katharine E. D'AQUINO - Perkasie PA, US
Wilson EDWARDS - Cardiff-by the-Sea CA, US
Ronald V. SWANSON - Del Mar CA, US
Wenying JIAN - Princeton NJ, US
Yue-Mei ZHANG - Wellesley MA, US
Mark J. WALL - Lansdale PA, US
Ellen CHI - San Diego CA, US

International Classification:

C07K 14/575
A61K 47/68
C07K 16/24
A61K 9/00
A61K 38/17
A61K 38/26
C07K 1/06
C07K 1/107
A61K 47/64
A61P 3/10
A61K 49/00
C07K 1/12
C07K 1/18
C07K 5/02
A61K 47/60
A61P 3/08
A61P 3/00
A61P 3/04
A61P 3/06
A61K 38/22
A61K 45/06
C07K 16/00

Abstract:

The present invention comprises conjugates comprising a monoclonal antibody conjugated to a cyclic PYY peptide. The invention also relates to pharmaceutical compositions and methods for use thereof. The novel conjugates are useful for preventing, treating or ameliorating diseases and disorders disclosed herein.

US Patent:

20210094998, Apr 1, 2021

Filed:

Oct 30, 2020

Appl. No.:

17/085128

Inventors:

- Beerse, BE
Raymond J. PATCH - Yardley PA, US
Rui ZHANG - Belle Mead NJ, US
Martin A. CASE - San Diego CA, US
Mark J. WALL - Lansdale PA, US
Yue-Mei ZHANG - Wellesley MA, US
Shamina M. RANGWALA - Furlong PA, US
James N. LEONARD - Ambler PA, US
Raul C. CAMACHO - Philadelphia PA, US
Michael J. HUNTER - Santee CA, US
Katharine E. D'AQUINO - Perkasie PA, US
Wilson EDWARDS - Cardiff-by the-Sea CA, US
Ronald V. SWANSON - Del Mar CA, US
Wenying JIAN - Princeton NJ, US
Ellen CHI - San Diego CA, US

International Classification:

C07K 14/575
A61K 47/68
C07K 16/24
A61K 9/00
A61K 38/17
A61K 38/26
C07K 1/06
C07K 1/107
A61K 47/64
A61P 3/10
A61K 49/00
C07K 1/12
C07K 1/18
C07K 5/02
A61K 47/60
A61P 3/08
A61P 3/00
A61P 3/04
A61P 3/06
A61K 38/22
A61K 45/06
C07K 16/00

Abstract:

The present invention relates to a monoclonal antibody platform designed to be coupled to therapeutic peptides to increase the half-life of the therapeutic peptide in a subject. The invention also relates to pharmaceutical compositions and methods for use thereof.

US Patent:

20200385439, Dec 10, 2020

Filed:

Aug 21, 2020

Appl. No.:

16/947875

Inventors:

- Beerse, BE
Raymond J. Patch - Yardley PA, US
Rui Zhang - Belle Mead NJ, US
Martin A. Case - San Diego CA, US
Shamina M. Rangwala - Furlong PA, US
James N. Leonard - Ambler PA, US
Raul C. Camacho - Philadelphia PA, US
Michael J. Hunter - Santee CA, US
Katharine E. D'Aquino - Perkasie PA, US
Wilson Edwards - Cardiff-by the-Sea CA, US
Ronald V. Swanson - Del Mar CA, US
Wenying Jian - Princeton NJ, US
Yue-Mei Zhang - Wellesley MA, US
Mark J. Wall - Lansdale PA, US
Ellen Chi - San Diego CA, US

International Classification:

C07K 14/575
A61K 47/68
C07K 16/24
A61K 9/00
A61K 38/17
A61K 38/26
C07K 1/06
C07K 1/107
A61K 47/64
A61P 3/10
A61K 49/00
C07K 1/12
C07K 1/18
C07K 5/02
A61K 47/60
A61P 3/08
A61P 3/00
A61P 3/04
A61P 3/06
A61K 38/22
A61K 45/06
C07K 16/00

Abstract:

The present invention relates to a monoclonal antibody platform designed to be coupled to therapeutic peptides to increase the half-life of the therapeutic peptide in a subject. The invention also relates to pharmaceutical compositions and methods for use thereof.

US Patent:

20200283491, Sep 10, 2020

Filed:

Mar 16, 2020

Appl. No.:

16/820174

Inventors:

- Beerse, BE
Raymond J. PATCH - Yardley PA, US
Rui ZHANG - Belle Mead NJ, US
Martin A. CASE - San Diego CA, US
Shamina M. RANGWALA - Furlong PA, US
James N. LEONARD - Ambler PA, US
Raul C. CAMACHO - Philadelphia PA, US
Michael J. HUNTER - Santee CA, US
Katharine E. D'AQUINO - Perkasie PA, US
Wilson EDWARDS - Cardiff-by the-Sea CA, US
Ronald V. SWANSON - Del Mar CA, US
Wenying JIAN - Princeton NJ, US
Yue-Mei ZHANG - Wellesley MA, US
Mark J. WALL - Lansdale PA, US
Ellen CHI - San Diego CA, US

International Classification:

C07K 14/575
A61K 47/68
C07K 16/24
A61K 9/00
A61K 38/17
A61K 38/26
C07K 1/06
C07K 1/107
A61K 47/64
A61P 3/10
A61K 49/00
C07K 1/12
C07K 1/18
C07K 5/02
A61K 47/60
A61P 3/08
A61P 3/00
A61P 3/04
A61P 3/06
A61K 38/22
A61K 45/06
C07K 16/00

Abstract:

The present invention comprises conjugates comprising a monoclonal antibody conjugated to a cyclic PYY peptide. The invention also relates to pharmaceutical compositions and methods for use thereof. The novel conjugates are useful for preventing, treating or ameliorating diseases and disorders disclosed herein.