3229 Foxcroft Rd, Little Rock, AR 72227 • (501)2247731
Santa Fe, NM
Bee Branch, AR
Work
Company:
UNIVERSITY HOSPITAL ARKANSAS
Address:
4301 W Markham St, Little Rock, AR 72205
Phones:
(501)6867000 (501)6868139
Education
School / High School:
Universitetet I Oslo, Det Medisinske Fakultet
1977
Skills
Cancer Research • Cancer • Clinical Trials • Medicine • Radiation • Radiation Therapy • Clinical Research • Radiation Biology • Science • Drug Development • Healthcare • General Surgery • Infectious Diseases • Surgery
Languages
English
Industries
Hospital & Health Care
Specialities
General Surgery
Us Patents
Methods To Treat And/Or Prevent Radiation- And/Or Chemical-Induced Toxicity In Non-Malignant Tissue
Martin Hauer-Jensen - Little Rock AR, US Chen Zong - Metuchen NJ, US
International Classification:
A61K 31/44 A61P 39/00
US Classification:
514337000
Abstract:
The present invention relates to methods useful for treating and/or preventing radiation- and/or chemical-induced toxicity in non-malignant tissue using a protease activated receptor-1 (PAR-1) inhibitor. In particular, use of a protease activated receptor-1 (PAR-1) inhibitor to treat and/or prevent acute and chronic adverse effects of radiation and/or chemical exposure (e.g., to one or more of the following: intestine, lung, oral mucosa, or other organs).
Use Of Statins In The Prevention And Treatment Of Radiation Injury And Other Disorders Associated With Reduced Endothelial Thrombomodulin
Martin K. Hauer-Jensen - Little Rock AR, US Louis M. Fink - Little Rock AR, US Jawahar Lal Mehta - Little Rock AR, US Junru Wang - Little Rock AR, US Jacob Joseph - Little Rock AR, US
Assignee:
The University of Arkansas for Medical Sciences - Little Rock AR
The present invention discloses statins (3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors) consistently and significantly increased endothelial cell thrombomodulin protein and functional activity. Statins also abrogated the downregulation of thrombomodulin that occurs in response to radiation injury. These results indicate that preserving or restoring endothelial thrombomodulin expression and function by statins may be useful in a variety of disorders associated with widespread endothelial dysfunction such as sepsis, adult respiratory distress syndrome, and normal tissue radiation injury.
Karl-Uwe Petersen - Aachen, DE Martin Hauer-Jensen - Little Rock AR, US
Assignee:
PAION Deutschland GmbH - Aachen
International Classification:
A61K 38/36 C07K 14/745 A61P 39/00
US Classification:
514 137, 530381
Abstract:
The invention relates to the field of radiation injury. More particularly, this invention relates to the protection against/prevention of and treatment of diseases caused by ionizing radiation by the use of thrombomodulin.
Philip J. Breen - Little Rock AR, US K. Sree Kumar - Rockville MD, US Cesar Compadre - Little Rock AR, US Martin Hauer-Jensen - Little Rock AR, US Kottayil Varughese - Little Rock AR, US
Assignee:
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF VETERAN AFFAIRS - Washington DC THE BOARD OF TRUSTEES FOR THE UNIVERSITY OF ARKANSAS - Little Rock AR
International Classification:
C07D 311/72
US Classification:
514456, 549408
Abstract:
Tocol derivative compounds, compositions comprising these tocol derivatives and methods of using the tocol derivatives are provided herein. Specifically the tocol derivatives have a partially unsaturated hydrocarbon tail and are thus distinct from the tocopherols. The hydrocarbon tails do not have a trans carbon-carbon double bond in the second isoprene unit of the hydrocarbon tail and are distinct from the tocotrienols. The compounds are expected to allow improved interaction with the α-tocopherol transfer protein receptor than the tocotrienols and better bioactivity than the tocopherols.
Martin Hauer-Jensen - Little Rock AR Paivi Aho - Helsinki, FI
Assignee:
The Board of Trustees of the University of Arkansas - Little Rock AR
International Classification:
A61K 4900
US Classification:
424 91, 424 111, 424 165
Abstract:
Intestinal radiation injury (radiation enteropathy) is an important dose limiting factor during treatment of abdominal and pelvic tumors and a major determinant in the quality of life among cancer survivors. Inflammatory and fibrogenic mediators released by mucosal inflammatory cells are involved in the mechanisms of injury. Treatment with Orazipone decreases the toxicity following Gy radiation dose, as measured by histopathologic scoring, TGF-, IL-1, and ED- macrophage antigen immunoreactivity.
- Little Rock AR, US - Washington DC, US Martin Hauer-Jensen - Little Rock AR, US Kottayil Varughese - Little Rock AR, US K. Sree Kumar - Rockville MD, US
Assignee:
BIOVENTURES, LLC - Little Rock AR THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS - Washington DC
International Classification:
C07D 311/72 C07D 311/58
Abstract:
Tocol derivative compounds, compositions comprising these tocol derivatives and methods of using the tocol derivatives are provided herein. Specifically the tocol derivatives have a partially unsaturated hydrocarbon tail and are thus distinct from the tocopherols. The hydrocarbon tails do not have a trans carbon-carbon double bond in the second isoprene unit of the hydrocarbon tail and are distinct from the tocotrienols. The compounds are expected to allow improved interaction with the a-tocopherol transfer protein receptor than the tocotrienols and better bioactivity than the tocopherols.
Use Of Rice Bran Oil Distillate Extract For Prevention And Mitigation Of The Effects Of Radiation
- Little Rock AR, US Philip Breen - Little Rock AR, US Nukhet Aykin-Burns - Little Rock AR, US Martin Hauer-Jensen - Little Rock AR, US
Assignee:
Tocol Pharmaceuticals, LLC - Little Rock AR
International Classification:
A61K 31/353 A61K 36/899 A61K 31/01 A61K 45/06
Abstract:
Provided herein is a tocol rich fraction of rice bran oil deodorized distillate that is shown to be both radioprotective and able to protect against oxidative damage. This fraction may prove an inexpensive and readily available extract that can be used to prepare pharmaceutical compositions for use in protecting against radiation exposure and/or other forms of oxidative stress.
Preparation And Use Of A Composition For Prevention And Mitigation Of The Effects Of Radiation
- Little Rock AR, US - Loja, EC - Washington DC, US Martin Hauer-Jensen - Little Rock AR, US Raul G. Enriquez - Coyoacan, MX Sujay Kharade - Little Rock AR, US Omar Malagon - Loja, EC Yadira Ordonez - Loja, EC Edgar Ojeda - Loja, EC Shraddha Thakkar - Little Rock AR, US E. Nathalie Pineda - Little Rock AR, US Darin Jones - Little Rock AR, US
Assignee:
BioVentures, LLC - Little Rock AR Universidad Tecnica Particular De Loja - Loja The United States of America as Represented by the Department of Veterans Affairs - Washington DC
International Classification:
A61K 31/355 A61K 36/185
Abstract:
Plant extracts, compositions, pharmaceutical compositions and methods of making and using the same are provided herein. The compositions comprise γ-tocotrienol (GT3) and δ-tocotrienol (DT3) in ratios wherein the DT3 is predominate. The compositions are useful for radioprotection and radiomitigation in subjects in need thereof.
Medicine Doctors
Dr. Martin Hauer-Jensen, Little Rock AR - MD (Doctor of Medicine)
Central Arkansas Veterans Healthcare System Jul 1991 - Apr 2017
Staff Surgeon
University of Arkansas For Medical Sciences Jul 1991 - Apr 2017
Professor of Pharmaceutical Sciences
University of Arkansas For Medical Sciences Jul 1991 - Apr 2017
Associate Dean For Research, College of Pharmacy
University of Arkansas For Medical Sciences Jul 1991 - Apr 2017
Director, Division of Radiation Health
University of Arkansas For Medical Sciences Jul 1991 - Apr 2017
Professor of Surgery and Pathology
Education:
University of Oslo (Uio) 1988
Doctorates, Doctor of Philosophy, Biology
University of Iowa 1985 - 1987
University of Oslo (Uio) 1971 - 1977
Doctor of Medicine, Doctorates, Medicine
Skills:
Cancer Research Cancer Clinical Trials Medicine Radiation Radiation Therapy Clinical Research Radiation Biology Science Drug Development Healthcare General Surgery Infectious Diseases Surgery
Youtube
my Showreel 2010
This is my showreel 2010 includes a selection of my films: Jensen (act...