Martin S Kluger

US Patent:

20080176796, Jul 24, 2008

Filed:

Apr 11, 2006

Appl. No.:

11/911177

Inventors:

John Bradley - Cambridge, GB
Jordan Pober - New Haven CT, US
Paul Clark - New Haven CT, US
Wang Min - New Haven CT, US
Martin Kluger - New Haven CT, US

International Classification:

A61K 31/70
G01N 33/00
G01N 33/566
C12Q 1/02
A61P 1/00
A61P 9/00
G01N 33/53
G01N 33/567
A61K 38/00

US Classification:

514 12, 436 86, 436501, 435 29, 435 71, 435 721, 514 44

Abstract:

This invention relates to the identification and characterisation of specific cellular responses which are associated with tumour necrosis factor receptor 1 (TNFR1) and tumour necrosis factor receptor 1 (TNFR2). Selective modulation of these tumour necrosis factor receptors (TNFRs) Selective modulations of these responses may be useful in the promotion or inhibition of cell growth, for example, in the treatment of disease conditions, including cardiovascular and kidney diseases. Therapeutic methods employed selective TNFR1 and TNFR2 modulators are provided, along with screening methods for the identification of selective TNFR1 and TNFR2 modulators useful in such methods.