Matthew T Duncan

US Patent:

20140128399, May 8, 2014

Filed:

Dec 6, 2013

Appl. No.:

14/098839

Inventors:

- DURHAM NC, US
Brian L. Bishop - Durham NC, US
Matthew J. Duncan - Duncan SC, US
K. Ranga Rama Krishnan - Chapel Hill NC, US
Jeongmin Song - Chapel Hill NC, US
Guojie Li - Charlotte NC, US
David W. Zaas - Chapel Hill NC, US

Assignee:

DUKE UNIVERSITY - DURHAM NC

International Classification:

A61K 31/53
A61K 45/06
A61K 31/4985
A61K 31/519

US Classification:

514243, 5142611, 51425216, 5142621, 514250

Abstract:

Methods and compositions are provided for treating a urinary tract infection (UTI). The methods involve administering to a subject in need thereof a cAMP elevator or agent that mimics cAMP, particularly a labdane diterpene such as forskolin or a derivative or analog thereof in a therapeutically effective amount to treat a UTI. The methods may further include administration of at least one cAMP elevator in combination with one or more additional active compounds from other classes of therapeutic agents, such as antimicrobial agents or cholesterol lowering drugs. Compositions of the invention include pharmaceutical compositions and kits for treating a UTI in a subject in need thereof that include therapeutically effective amounts of at least two cAMP elevators, particularly where one of the cAMP elevators is a labdane diterpene such as forskolin or a derivative or analog thereof. In particular, the compositions and kits may also include at least one cAMP elevator in combination with one or more additional active compounds from other classes of therapeutic agents, such as antimicrobial agents or cholesterol lowering drugs.