Michael Jay Austin

US Patent:

8628919, Jan 14, 2014

Filed:

Jun 30, 2009

Appl. No.:

13/001697

Inventors:

Ming Xiao - Huntingdon Valley PA, US
Parikshit A. Deshpande - Princeton NJ, US
Han Cao - Philadelphia PA, US
Michael Austin - Philadelphia PA, US
Kandaswamy Vijayan - San Diego CA, US
Alexey Y. Sharonov - Hamden CT, US
Michael Boyce-Jacino - Titusville NJ, US

Assignee:

Bionano Genomics, Inc. - Philadelphia PA

International Classification:

C12Q 1/68
C12M 1/34
C12M 3/00
C07H 21/02

US Classification:

435 61, 435 611, 4352872, 536 231, 977704

Abstract:

Provided are methods and devices for single-molecule genomic analysis. In one embodiment, the methods entail processing a double-stranded nucleic acid and characterizing said nucleic acid. These methods are useful in, e. g. , determining structural variations and copy number variations between individuals.

US Patent:

20060281443, Dec 14, 2006

Filed:

May 18, 2005

Appl. No.:

11/132727

Inventors:

Michael Chen - Pittstown NJ, US
Robert Ephraim - Bridgewater NJ, US
Tyler McCue - Lantana TX, US
Michael Austin - Roanoke TX, US

International Classification:

H04M 11/10

US Classification:

455413000

Abstract:

A method and system is disclosed for facilitating voice mailbox operations for a mobile phone capable of operating in both a CDMA and a GSM environment. The system has at least first and second switching points and a global switching point in communication with a control point. Upon a first switching point detecting a busy/no answer condition for a request to terminate a call to a called station (the call originating from a calling station), the first switching point forwards the terminating call to a temporary, unique forward-to number belonging to the global switching point which then sends at least one message to the control point, the at least one message identifying the unique forward-to number designating a voice mailbox. The control point then identifies the second switching point from the unique forward-to number and sends a first call treatment message instructing the second switching point to apply voicemail treatment at a voice mailbox linked thereto.

US Patent:

20080242556, Oct 2, 2008

Filed:

Mar 28, 2008

Appl. No.:

12/057987

Inventors:

Han Cao - Philadelphia PA, US
Parikshit A. Deshpande - Philadelphia PA, US
Michael D. Austin - Philadelphia PA, US
Michael Boyce-Jacino - Titusville NJ, US

Assignee:

BIONANOMATRIX, LLC - Philadelphia PA

International Classification:

C40B 30/04
C40B 60/12
C40B 30/10
C40B 30/06

US Classification:

506 9, 506 39, 506 12, 506 10

Abstract:

Methods of analyzing features such as the physical size of macromolecules or biomarkers along large genomic DNA molecules were disclosed as well as the devices for carrying out such high throughput analysis in a massively parallel fashion. Methods of fabricating such devices are also disclosed.

US Patent:

20090305273, Dec 10, 2009

Filed:

Jul 19, 2007

Appl. No.:

12/374141

Inventors:

Han Cao - Philadelphia PA, US
Parikshit A. Deshpande - Princeton NJ, US
Michael D. Austin - Philadelphia PA, US
Michael Boyce-Jacino - Titusville NJ, US

Assignee:

BIONANOMATRIX, INC. - PHILADELPHIA PA

International Classification:

C12Q 1/68
C12M 1/34

US Classification:

435 6, 4352872

Abstract:

Constricted nanochannel devices suitable for use in analysis of macromolecular structure, including DNA sequencing, are disclosed. Also disclosed are methods for fabricating such devices and for analyzing macro-molecules using such devices.

US Patent:

20110296903, Dec 8, 2011

Filed:

Jun 5, 2009

Appl. No.:

12/996410

Inventors:

Han Cao - Philadelphia PA, US
Michael D. Austin - Philadelphia PA, US
Parikshit A. Deshpande - Princeton NJ, US
Mark Kunkel - Lawrenceville NJ, US
Alexey Y. Sharonov - Hamden CT, US
Michael Kochersperger - Princeton NJ, US

Assignee:

Bionanomatrix, Inc. - Philadelphai PA

International Classification:

G01N 1/16
B32B 37/16
B23P 17/00
G01N 21/64
B32B 37/02
B82Y 15/00

US Classification:

73 6456, 2504591, 156292, 29423, 977902, 977781

Abstract:

Provided are integrated analysis devices having features of macroscale and nanoscale dimensions, and devices that have reduced background signals and that reduce quenching of fluorophores disposed within the devices. Related methods of manufacturing these devices and of using these devices are also provided.

US Patent:

20120244635, Sep 27, 2012

Filed:

Sep 27, 2010

Appl. No.:

13/498846

Inventors:

Michael Austin - Philadelphia PA, US
Parikshit A. Deshpande - Princeton NJ, US
Alexey Sharonov - Drexel Hill PA, US
Valeriy Bogdanov - Philadelphia PA, US

Assignee:

BIONANO GENOMICS, INC. - San Diego CA

International Classification:

G01N 21/64
B82Y 15/00

US Classification:

436501, 422 69, 977781, 977902, 977920

Abstract:

Provided are devices and methods for polymer analysis, in which labeled polymers are translocated along nanochannels that have illuminated detection regions within. As a labeled polymer translocates along the nanochannel and the labels pass over the illuminated detection regions, the labels become detectable (e.g., where different labels fluoresce in response to different wavelengths present at different illumination regions), and the user generates a spatial map of the location of the various labels along the length of the polymer. The location of the labels is then correlated to one or more structural characteristics of the polymer.