Michael Bolger - Los Alamitos CA Kelvin W. Gee - Hacienda Heights CA Nancy C. Lan - S. Pasadena CA Delia Belelli - Rowland Heights CA Seid Mirsadeghi - Sherman Oaks CA Robert Purdy - San Antonio TX
Assignee:
University of Southern California - Los Angeles CA
International Classification:
A61K 3158 A61K 3156 C07J 4300 C07J 4100
US Classification:
514176
Abstract:
Method, compositions, and compounds for modulating brain excitability to alleviate stress, anxiety, insomnia and seizure activity using certain steroid derivatives that act at a newly identified site on the gamma-aminobutyric acid receptor-chloride ionophore (GR) complex.
Method, Compositions, And Compounds For Modulating Brain Excitability
Method, compositions, and compounds for modulating brain excitability to alleviate stress, anxiety, and seizure activity using certain steroid derivatives that act at a newly identified site on the gamma-ammobutyric acid/benzodiazepine receptor-chloride ionpore (GBR) complex.
Method For Making 3.Alpha.-Hydroxy, 3.Beta.-Substituted-Pregnanes
Hasan Tahir - Pasadena CA Michael Bolger - Los Alamitos CA Richard Buswell - Santa Rosa CA Richard Gabriel - Woburn MA Jay Stearns - Santa Rosa CA
Assignee:
Cocensys Inc. - Irvine CA
International Classification:
C07J 2100 C07J 4300 C07J 4100
US Classification:
552609
Abstract:
This invention provides a simplified method for converting pregnan-3,20-dione compounds to 3. alpha. -hydroxy,3. beta. -substituted-pregnanes. By selective use of reagents the unprotected dione is converted chemoselectively and diastereoselectively into a 3(R)-pregnan-3-spiro-2'oxirane-20-one intermediate. This intermediate can then be converted regioselectively by a second set of reactions to the 3. alpha. -hydroxy,3. beta. -substituted-20-one form, which can be further modified at the 20-keto position. Through this method, each ketone group is independently treated. By modifying the ketones one at a time, one can obtain the desired stereo-specificity at each site.
Methods, Compositions, And Compounds For Allosteric Modulation Of The Gaba Receptor By Members Of The Androstane And Pregnane Series
Michael B. Bolger - Los Alamitos CA Kelvin W. Gee - Irvine CA Nancy C. Lan - South Pasadena CA Robert H. Purdy - La Jolla CA Seid Mirsadeghi - Rolling Hills CA Syed Hasan Tahir - Edmonton, CA Delia Belelli - Kingsbarns by St. Andrews, GB6
Assignee:
University of Southern California - Los Angeles CA
International Classification:
C07J 900 C07J 2100 C07J 4300 A61K 3158 A61K 3156
US Classification:
514172
Abstract:
Method, compositions, and compounds for modulating brain excitability to alleviate stress, anxiety, insomnia and seizure activity using certain steroid derivatives that act at a newly identified site on the gamma-aminobutyric acid receptor-chloride ionophore (GR) complex.
Method, Compositions, And Compounds For Modulating Brain Excitability
Kelvin W. Gee - Hacienda Heights CA Michael B. Bolger - Los Alamitos CA Roberta E. Brinton - New York NY Deborah J. Burke - Hacienda Heights CA Bruce S. McEwen - Englewood NJ
Assignee:
University of Southern California - Los Angeles CA
International Classification:
A61K 3158 A61K 3156 C07J 4300 C07J 4100
US Classification:
514172
Abstract:
Method, compositions, and compounds for modulating brain excitability to alleviate stress, anxiety, and seizure activity using certain steroid derivatives that act at a newly identified site on the gamma-ammobutyric acid/benzodiazepine receptor-chloride ionophore (GBR) complex.
Method, Compositions, And Compounds For Modulating Brain Excitability
Method, compositions, and compounds for modulating brain excitability to alleviate stress, anxiety, and seizure activity using certain steroid derivatives that act at a newly identified site on the gamma-ammobutyric acid/benzodiazepine receptor-chloride ionpore (GBR) complex.
Missouri Baptist Cancer Center 3844 S Lindbergh Blvd STE 130, Saint Louis, MO 63127 (314)5250550 (phone), (314)5250551 (fax)
Midwest Oncology & Hematology 3015 N Ballas Rd, Saint Louis, MO 63131 (314)9965169 (phone), (314)9964679 (fax)
Education:
Medical School Washington University School of Medicine Graduated: 1981
Procedures:
Bone Marrow Biopsy Chemotherapy
Conditions:
Lung Cancer Non-Hodgkin's Lymphoma Pancreatic Cancer Anemia Gastric Cancer
Languages:
English
Description:
Dr. Bolger graduated from the Washington University School of Medicine in 1981. He works in Saint Louis, MO and 1 other location and specializes in Hematology/Oncology and Internal Medicine. Dr. Bolger is affiliated with Missouri Baptist Medical Center.
Name / Title
Company / Classification
Phones & Addresses
Michael P. Bolger President
SVG FOUNDATION
23016 Lk Frst Dr #A472, Laguna Hills, CA 92653
Michael J. Bolger President
M. T. PATRICK CONSTRUCTION CO
3004 Verdugo Rd, Los Angeles, CA 90065
Michael P. Bolger President
WEBFORMSFOUNDRY INCORPORATED
28235 Driza, Mission Viejo, CA 92692
Michael J. Bolger President
WM. S. BRIAN CONST. CO., INC
3004 Verdugo Rd, Los Angeles, CA 90065
Michael J. Bolger Manager
Michael B, LLC Business Services at Non-Commercial Site
710 3 St, San Diego, CA 92118
Michael Bolger Treasurer, Director, Secretary
The Arc Group, Inc.-Illinois
Michael J. Bolger
Michael B. Gourmet Foods, LLC Food Services
695 Town Ctr Dr, Costa Mesa, CA 92626 3907 W Verdugo Ave, Burbank, CA 91505
University of Southern California Nov 1980 - May 2004
Associate Professor of Pharmaceutical Sciences
Simulations Plus, Inc. Nov 1980 - May 2004
Chief Scientist at Simulations Plus, Inc
Cocensys Inc Feb 1987 - Jul 1993
Director of Medicinal Chemistry
Education:
University of California, San Francisco 1973 - 1977
Doctorates, Doctor of Philosophy, Chemistry
Uc San Diego 1969 - 1973
Bachelors, Bachelor of Arts, Biology, Chemistry
University of California
Skills:
Pharmacokinetics Drug Discovery Medicinal Chemistry Drug Development Chemistry Pharmaceutical Industry In Vitro Pharmacology Computational Chemistry Drug Design Life Sciences Cell Culture Biochemistry Clinical Trials Mathematical Modeling Science Biopharmaceuticals Fda Molecular Modeling Lifesciences Bioinformatics Cheminformatics Computational Biology Simulations Analytical Chemistry Monoclonal Antibodies
Officials identified the six people who were killed in Madison County as Melissa Bazley, 63; Rodney Clark, 64; Cecilia Lloyd, 72; Michael Bolger, 37; Kinlee Bolger, 5; and Owen Bolger, 2. The victims came from three different households.