Michael B Consilvio

US Patent:

6627648, Sep 30, 2003

Filed:

Aug 13, 2001

Appl. No.:

09/928984

Inventors:

Gary Maurice Dull - Lewisville NC
Erin E. Reich - Nashville TN
Jared Miller Wagner - Stillwater OK
Balwinder Singh Bhatti - Winston-Salem NC
Michael B. Consilvio - Potomac MD

Assignee:

Targacept, Inc. - Winston-Salem NC

International Classification:

A61K 3144

US Classification:

514351, 514357, 546300, 546315, 546334

Abstract:

Patients susceptible to or suffering from conditions and disorders, such as central nervous system disorders, are treated by administering to a patient in need thereof aryloxyalkylamines and arylthioalkylamines, including pyridyloxyl-alkylamines, phenoxyalkylamines, pyridylthiolalkylamines and phenylthio-alkylamines. Exemplary compounds include (2-(5-bromo(3-pyridylthio))-ethyl)methylamine, (2-(5-bromo(3-pyridylthio))isopropyl)methylamine, (2-(5-bromo(3-pyridylthio))propyl)methylamine, (3-(5-bromo(3-pyridylthio))-propyl)methylamine, 3-((3S)-3-pyrrolidinyloxy)pyridine, 3-(4-piperidinyloxy)pyridine, 3-(1-methyl-4-piperidinyloxy)pyridine, (3-benzo[3,4-d]1,3-dioxolan-5-yloxypropyl)methylamine, and methyl(3-tricyclo[7. 3. 1. 05,13 ]tridec-2-yloxypropyl)amine.

US Patent:

20010014691, Aug 16, 2001

Filed:

May 24, 1999

Appl. No.:

09/317321

Inventors:

GARY MAURICE DULL - LEWISVILLE NC, US
JARED MILLER WAGNER - STILLWATER NC, US
MICHAEL B. CONSILVIO - POTOMAC MD, US

International Classification:

A61K031/505
A61K031/53
A61K031/44
A61K031/445

US Classification:

514/351000, 546/300000, 546/268100, 544/298000, 544/316000, 544/313000, 564/346000, 514/269000, 514/242000, 514/336000

Abstract:

Patients susceptible to or suffering from conditions and disorders, such as central nervous system disorders, are treated by administering to a patient in need thereof aryloxyalkylamines, including pyridyloxylalkylamines and phenoxyalkylamines. Exemplary compounds include dimethyl(2-(3-pyridyloxy)ethylamine, dimethyl(4-(3-pyridyloxy)butyl)amine, 2-(3-pyridyloxy)ethylamine, 4-(3-pyridyloxy)butylamine, methyl(3-(5-methoxy-3-pyridyloxy)propyl)amine, ethyl(3-(3-pyridyloxy)propyl)amine, methyl(2-(3-pyridyloxy)ethyl)amine, methyl(3-(6-methyl(3-pyridyloxy))propyl)amine, (3-(3-methoxyphenoxy)propyl)methylamine, (3-(5-chloro(3-pyridyloxy))-1-methylpropyl)methylamine, dimethyl(3-(3-pyridyloxy)propyl)amine, 3-(3-pyridyloxy)propylamine, methyl(4-(3-pyridyloxy)butyl)amine, 3-(5-chloro-3-pyridyloxy)propyl amine, methyl(3-(5-isopropoxy-3-pyridyloxy)propyl)amine, (3-(5-chloro(3-pyridyloxy))propyl) methylamine, methyl(3-(5-(phenylmethoxy)(3-pyridyloxy))propyl)amine, methyl(3-(2-methyl(3-pyridyloxy))propyl)amine, (methylethyl)(3-(3-pyridyloxy)propyl)amine, benzyl(3-(3-pyridyloxy)propyl)amine, cyclopropyl(3-(3-pyridyloxy)-propyl)amine, methyl(1-methyl-3-(3-pyridyloxy)propyl)amine, methyl(3-(3-nitrophenoxy)propyl)amine, 1-(3-chloropropoxy)-3-nitrobenzene, (3-(3-aminophenoxy)propyl)methylamine,dimethyl (3-(3-(methylamino)-propoxy)phenyl)amine, methyl(3-tricyclo[7.3.1.0

US Patent:

20010031771, Oct 18, 2001

Filed:

May 24, 1999

Appl. No.:

09/317327

Inventors:

GARY MAURICE DULL - WINSTON-SALEM NC, US
ERIN E. REICH - WINSTON-SALEM NC, US
JARED MILLER WAGNER - WINSTON-SALEM NC, US
BALWINDER SINGH BHATTI - WINSTON-SALEM NC, US
MICHAEL B. CONSILVIO - WINSTON-SALEM NC, US

International Classification:

A61K031/44
A61K031/166
A61K031/505

US Classification:

514/351000, 546/193000, 546/300000, 546/276400, 544/316000, 549/346000, 564/346000, 549/465000, 514/269000, 514/646000

Abstract:

Patients susceptible to or suffering from conditions and disorders, such as central nervous system disorders, are treated by administering to a patient in need thereof aryloxyalkylamines and arylthioalkylamines, including pyridyloxylalkylamines, phenoxyalkylamines, pyridylthiolalkylamines and phenylthioalkylamines. Exemplary compounds include (2-(5-bromo(3-pyridylthio))ethyl)methylamine, (2-(5-bromo(3-pyridylthio))isopropyl)methylamine, (2-(5-bromo(3-pyridylthio))propyl)methylamine, (3-(5-bromo(3-pyridylthio))propyl)methylamine, 3-((3S)-3-pyrrolidinyloxy)pyridine, 3-(4-piperidinyloxy)pyridine, 3-(1-methyl-4-piperidinyloxy)pyridine, (3-benzo[3,4-d]1,3-dioxolan-5-yloxypropyl)methylamine, and methyl(3-tricyclo[7.3.1.0