Michael C Dore

US Patent:

20190185475, Jun 20, 2019

Filed:

Jun 15, 2016

Appl. No.:

15/736959

Inventors:

- Basel, CH
Zhuoliang Chen - Belmont MA, US
Michael Dore - Wilmington MA, US
Jorge Garcia Fortanet - Wilmington MA, US
Mitsunori Kato - Cambridge MA, US
Matthew J. LaMarche - Reading MA, US
Patrick James Sarver - Princeton NJ, US
Michael Shultz - Cambridge MA, US
Troy Douglas Smith - Nashua NH, US
Sarah Williams - Emeryville CA, US

International Classification:

C07D 487/04
A61P 35/00
C07D 519/00

Abstract:

The present invention relates to compounds of formula I:

US Patent:

20180201623, Jul 19, 2018

Filed:

Feb 20, 2018

Appl. No.:

15/899821

Inventors:

- Basel, CH
Zhuoliang Chen - Belmont MA, US
Michael Dore - Wilmington MA, US
Jorge Garcia Fortanet - Wilmington MA, US
John William Giraldes - Windsor Mill MD, US
Rajesh Karki - Quincy MA, US
Mitsunori Kato - Cambridge MA, US
Matthew J. LaMarche - Reading MA, US
Lawrence Blas Perez - Silver Spring MD, US
Martin Sendzik - Belmont MA, US
Troy Douglas Smith - Nashua NH, US
Bakary-Barry Toure - Weston MA, US
Sarah Williams - Emeryville CA, US

International Classification:

C07D 498/10
C07D 401/14
C07D 495/10
C07D 241/18
C07D 241/20
C07D 401/04
C07D 403/04
C07D 471/10
C07D 491/107

Abstract:

The present invention relates to compounds of formula I:

US Patent:

20180065949, Mar 8, 2018

Filed:

Oct 5, 2017

Appl. No.:

15/726189

Inventors:

- Basel, CH
Michael Dore - Wilmington MA, US
Jorge Garcia Fortanet - Wilmington MA, US
Rajesh Karki - Quincy MA, US
Mitsunori Kato - Cambridge MA, US
Matthew J. LaMarche - Reading MA, US
Lawrence Blas Perez - Silver Spring MD, US
Sarah Williams - Emeryville CA, US
Martin Sendzik - Belmont MA, US

International Classification:

C07D 401/04
C07D 401/14
C07D 249/14
C07D 241/26

Abstract:

The present invention relates to compounds of formula I:

US Patent:

20170015680, Jan 19, 2017

Filed:

Jan 16, 2015

Appl. No.:

15/110511

Inventors:

Christine Hiu-Tung Chen - Waltham MA, US
Zhuoliang Chen - Belmont MA, US
Michael Dore - Wilmington MA, US
Jorge Garcia Fortanet - Somerville MA, US
Rajesh Karki - Quincy MA, US
Mitsunori Kato - Cambridge MA, US
Matthew J. LaMarche - Reading MA, US
Lawrence Blas Perez - Hopkinton MA, US
Troy Douglas Smith - Nashua NH, US
Sarah Williams - Emeryville CA, US
John William Giraldes - Windsor Mill MD, US
Martin Sendzik - Belmont MA, US
Bakary-Barry Toure - Weston MA, US

Assignee:

NOVARTIS AG - Basel

International Classification:

C07D 498/10
C07D 403/04
C07D 471/10
C07D 491/107
C07D 495/10
C07D 401/04
C07D 401/14

Abstract:

The present invention relates to compounds of formula I:in which p, q, Y, Y, R, R, R, R, R, R, R, R, R, Rand Rare defined in the Summary of the Invention; capable of inhibiting the activity of SHP2. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds and compositions in the management of diseases or disorders associated with the aberrant activity of SHP2.

US Patent:

20170001975, Jan 5, 2017

Filed:

Jan 16, 2015

Appl. No.:

15/110504

Inventors:

Zhuoliang CHEN - Belmont MA, US
Michael DORE - Cambridge MA, US
Jorge Garcia FORTANET - Somerville MA, US
Rajesh KARKI - Cambridge MA, US
Mitsunori KATO - Cambridge MA, US
Matthew J. LAMARCHE - Cambridge MA, US
Lawrence Blas PEREZ - Hopkinton MA, US
Sarah WILLIAMS - Emeryville CA, US
Martin SENDZIK - Cambridge MA, US

Assignee:

NOVARTIS AG - Basel

International Classification:

C07D 401/04
C07D 401/14

Abstract:

The present invention relates to compounds of formula I: