Michael Scott Greene

US Patent:

20060009068, Jan 12, 2006

Filed:

Jul 6, 2004

Appl. No.:

10/884509

Inventors:

Michael Greene - Sherman Oaks CA, US
Kirk Langman - Beverly Hills CA, US

International Classification:

H01R 3/00

US Classification:

439488000

Abstract:

Cable Label with a connector portion and a tag portion The tag portion is fixedly attached to the connector portion by a flexible tab. The connector portion can be of two types, one shaped to frictionally receive the end of a standard female phone jack and the second shaped to receive the end of a standard male jack. The tag portion is comprised of a flat elongate plate that includes a flat surface to receive writing or attachment of a paper label that can be written on. A preferred embodiment includes a plurality of non printed or pre-printed paper labels that can be attached to the flat surface of the tag portion. A preferred embodiment includes the paper labels having pre-printed numbers or letters or the like.

US Patent:

20130203083, Aug 8, 2013

Filed:

Feb 10, 2011

Appl. No.:

13/578294

Inventors:

Lawreen Connors - Woburn MA, US
Michael J. Greene - Allston MA, US

Assignee:

TRUSTEES OF BOSTON UNIVERSITY - Boston MA

International Classification:

G01N 33/68

US Classification:

435 792, 436501, 435 71, 422 69, 4352872

Abstract:

The present invention relates generally to diagnostic methods, systems, assays and kits for identification of subjects with cardiac amyloid deposits, where a low level of clusterin protein in a peripheral fluid sample, e.g., a serum sample from the subject, indicates the subject likely has cardiac amyloid deposits. Other aspects relate to methods of treatment of diseases or disorders characterized by cardiac amyloid deposits and transthyretin (TTR) amyloidosis, and more particularly to methods of treatment of cardiac-related amyloidosis and cardiac amyloid deposits in subjects with familial transthyretin (TTR), senile systemic amyloidosis (SSA), or familial amyloidodic polyneuropathy (FAP), or immunoglobulin light chain (AL) amyloidosis. Other aspects relate to methods and compositions comprising clusterin (CLU) or a clusterin agent (e.g. an agonist of clusterin activity or a biologically active fragment or derivative thereof), and their use in methods to treat a disease or disorder characterized by transthyretin (TTR) amyloidosis, e.g. senile systemic amyloidosis (SSA) or familial amyloidodic polyneuropathy (FAP), and their use in methods to treat amyloidotic cardiomyopathy associated with transthyretin (TTR) amyloidosis.

US Patent:

20140058763, Feb 27, 2014

Filed:

Jul 24, 2013

Appl. No.:

13/987437

Inventors:

Michael F. Greene - Boston MA, US
John R. Lucker - Simsbury CT, US
Steven E. Ellis - Linthicum Heights MD, US
James C. Guszcza - Santa Monica CA, US
Steven L. Berman - Havertown PA, US
Amin Torabkhani - New York NY, US

International Classification:

G06Q 40/08

US Classification:

705 4

Abstract:

An unsupervised statistical analytics approach to detecting fraud utilizes cluster analysis to identify specific clusters of claims or transactions for additional investigation, or utilizes association rules as tripwires to identify outliers. The clusters or sets of rules define a “normal” profile for the claims or transactions used to filter out normal claims, leaving “not normal” claims for potential investigation. To generate clusters or association rules, data relating to a sample set of claims or transactions may be obtained, and a set of variables used to discover patterns in the data that indicate a normal profile. New claims may be filtered, and not normal claims analyzed further. Alternatively, patterns for both a normal profile and an anomalous profile may be discovered, and a new claim filtered by the normal filter. If the claim is “not normal” it may be further filtered to detect potential fraud.

US Patent:

60929510, Jul 25, 2000

Filed:

Feb 5, 1998

Appl. No.:

9/019369

Inventors:

Michael Greene - Sherman Oaks CA
Kenneth Tarlow - Corte Madera CA
Kirk Langman - Beverly Hills CA

International Classification:

B43K 2102

US Classification:

401 99

Abstract:

An article of manufacture for causing a ball point pen cartridge and associated tip to automatically extend from its housing when an actuator switch located at the front end of the pen housing is pressed by the user's finger. The pen tip and associated cartridge automatically retract when the user releases the pen. A D. C. motor coupled to a gear reduction assembly inside the pen housing causes an attached threaded sleeve to rotate within a stationary nut within the housing thereby driving the pen assembly forward or backward depending on the polarity of the electrical supply to the motor. Limit switches within the housing cause the pen assembly to stop at the proper locations. An alternate embodiment of the design substitutes a non-moving, conductive switch that operates on skin contact instead of a moving, mechanical type actuation within a standard electrical switch.

US Patent:

59269561, Jul 27, 1999

Filed:

Feb 5, 1998

Appl. No.:

9/019335

Inventors:

Kirk Langman - Los Angeles CA
Michael Greene - Sherman Oaks CA
Kenneth Tarlow - Corte Madera CA

Assignee:

Kirk Langman - Los Angeles CA

International Classification:

A45D 2902

US Classification:

30 28

Abstract:

A combined toe and finger nail clipper having a common metal strip with a toe nail cutting edge at one end and a finger nail cutting edge at the opposite end. Mating nail cutting edges are at the ends of two additional metal strips which are each welded above and below at opposite ends of the common metal strip. A pair of vertical retaining posts located at each end of the nail clipping unit hold lever arms which can be stored in the flat position or rotated around and put into the use position as in conventional nail clippers. In this way a manufacturer can produce a combined toe and finger nail clipper more economically than two separate nail clippers and the user can store the combined nail clipper in a smaller space without worrying about locating two separate clippers. The clipper can be constructed so that while one of the clippers is in use the cutting edges of its other are closed or only slightly open so as to avoid the corners of the cutting edges catching or scratching a finger of the user.

US Patent:

20210220404, Jul 22, 2021

Filed:

Nov 25, 2020

Appl. No.:

17/104983

Inventors:

Michael R. Greene - Cambridge MA, US
- Basel, CH
Attilio Bondanza - Basel, CH
Jennifer Brogdon - Sudbury MA, US
Dexiu Bu - Melrose MA, US
Serena De Vita - Brookline MA, US
Glenn Dranoff - Sudbury MA, US
Boris Engels - Arlington MA, US
Tony Fleming - Stow MA, US
Brian Walter Granda - Salisbury MA, US
Michael R. Greene - Groton MA, US
Carla Patricia Guimaraes - Boston MA, US
Anniesha Hack - East Hanover MA, US
Brian Holmberg - Somerville MA, US
Connie Hong - Somerville MA, US
Lu Huang - West Roxbury MA, US
Olja Kodrasi - Quincy MA, US
Joni Waiee Lam - Somerville MA, US
Hyungwook Lim - Cambridge MA, US
Elizabeth Dorothy Pratico - East Boston MA, US
Andrew Price - Cambridge MA, US
Akash Sohoni - Cambridge MA, US
Andrew Marc Stein - Cambridge MA, US
Louise Treanor - Cambridge MA, US
Chonghui Zhang - Cambridge MA, US
Xu Zhu - Cambridge MA, US

International Classification:

A61K 35/17
C07K 16/28
A61P 35/00
A61K 45/06
A61K 39/395
C07K 14/705
A61K 38/17
C12N 5/0783
C07K 14/725

Abstract:

The invention provides immune effector cells (for example, T cells, NK cells) that express a chimeric antigen receptor (CAR), and compositions and methods thereof.

US Patent:

20200248130, Aug 6, 2020

Filed:

Jan 10, 2020

Appl. No.:

16/739573

Inventors:

- Basel, CH
- Philadelphia PA, US
Michael R. Greene - Cambridge MA, US
Lan Cao - East Hanover NJ, US

International Classification:

C12M 1/00
B03C 1/01
B03C 1/28
B03C 1/033
B03C 1/30
C12N 13/00
C12M 1/12
C07K 16/28

Abstract:

The present disclosure relates to systems and methods for flow-through separation of paramagnetic particle-bound cells in a cell suspension containing both bound and unbound cells as well as systems and methods for removing paramagnetic particles from paramagnetic particle-bound cells or from a cell suspension with unbound cells. It further relates to a flow-through magnetic separation/debeading module and a flow-through spinning membrane debeading module.

US Patent:

20190269727, Sep 5, 2019

Filed:

Dec 27, 2016

Appl. No.:

16/066788

Inventors:

Fabio Fachin - Brookline MA, US
Lan Cao - Morris Plains NJ, US
Michael R. Greene - Groton MA, US
Tatiana Golovina - Havertown PA, US
- Basel, CH
- Philadelphia PA, US

International Classification:

A61K 35/17
C07K 14/725
C12N 5/0783
C07K 1/04
A61M 1/34
A61M 1/36

Abstract:

The invention provides methods of making immune effector cells (e.g., T cells, NK cells) that can be engineered to express a chimeric antigen receptor (CAR), and compositions and reaction mixtures comprising the same.