Michael A Hauser

Address:

5017 Leasdale Rd, Rosedale, MD 21237

VIN:

1FMEU51K57UB49610

Make:

FORD

Model:

EXPLORER SPORT TRAC

Year:

2007

US Patent:

6451596, Sep 17, 2002

Filed:

May 2, 2000

Appl. No.:

09/562919

Inventors:

Jeffrey S. Chamberlain - Seattle WA
Andrea Amalfitano - Durham NC
Michael A. Hauser - Milan MI
Rajendra Kumar-Singh - Los Angeles CA

Assignee:

Regents of the University of Michigan - Ann Arbor MI

International Classification:

C12N 1586

US Classification:

435325, 4352351, 4353201, 435456, 536 231, 536 241

Abstract:

The present invention provides improved adenovirus vectors and packaging cell lines. One type of improved adenoviral vector comprises deletions within the E2b region of the adenoviral genome. These E2b-deleted virus are used in conjunction with novel cell lines that constitutively express E2b gene products. The present invention further provides adenoviral vectors deleted for all viral coding regions. These âguttedâ vectors permit the transfer of large genes to cells as demonstrated herein by the transfer of the dystrophin gene to the muscle of mice. The E2b-deleted vectors and the gutted vectors provide improved adenoviral vectors useful for a wide variety of gene therapy applications.

US Patent:

8088587, Jan 3, 2012

Filed:

Mar 6, 2006

Appl. No.:

11/885336

Inventors:

Jonathan L. Haines - Nashville TN, US
Eric Postel - Durham NC, US
Anita Agarwal - Nashville TN, US
Michael A. Hauser - Durham NC, US
Silke Schmidt - Durham NC, US
William K. Scott - Durham NC, US

Assignee:

Vanderbilt University - Nashville TN
Duke University - Durham NC

International Classification:

G01N 31/00
G01N 33/53

US Classification:

435 71, 435 4, 4352879, 436501, 436518, 436525, 436529, 436535, 436809, 530300, 530350, 422 50

Abstract:

Age-related macular degeneration (AMD) is a leading cause of visual impairment and blindness in the elderly whose etiology remains largely unknown. Previous studies identified chromosome 1q32 as harboring a susceptibility locus for AMD, but it was not identified. We identified a strongly associated haplotype in two independent data sets. DNA sequencing of the complement factor II gene (CFII) within this haplotype revealed a coding variant, Y402II, that significantly increases the risk for AMD with odds ratios between 2. 45 and 5. 57. This identifies Complement factor II as involved in pathogenesis of AMD. This single variant alone is so common that it likely explains 43 percent of AMD in older adults. In addition, we have replicated and refined previous reports implicating a coding change in LOC387715 as the second major AMD susceptibility allele. The effect of rs10490924 appears to be completely independent of the Y402H variant in the CFH gene.

US Patent:

20060068428, Mar 30, 2006

Filed:

Aug 31, 2005

Appl. No.:

11/216660

Inventors:

Jeffery Vance - Chapel Hill NC, US
Yi-Ju Li - Durham NC, US
Eden Martin - Hillsborough NC, US
William Scott - Durham NC, US
Michael Hauser - Durham NC, US
Jeffrey Stajich - Hillsborough NC, US
Sofia Oliveira - Lisbon, PT
Joelle van der Walt - Raleigh NC, US

International Classification:

C12Q 1/68

US Classification:

435006000

Abstract:

The present invention provides methods and compositions for screening a subject for Parkinson disease, for increased risk of developing Parkinson disease and/or for an earlier or later age of developing Parkinson disease, comprising detecting the presence of a genetic marker associated with Parkinson disease.

US Patent:

20060246437, Nov 2, 2006

Filed:

Jul 11, 2003

Appl. No.:

10/520695

Inventors:

Jeffery Vance - Chapel Hill NC, US
Marcy Speer - Durham NC, US
Michael Hauser - Durham NC, US

International Classification:

C12Q 1/68

US Classification:

435006000

Abstract:

The present invention is directed to a method for diagnosing a subject as being or having a predisposition to being asthmatic. The present invention is also directed to methods of detecting whether a subject may be atopic by screening for genetic risk factors.

US Patent:

20090098557, Apr 16, 2009

Filed:

Oct 6, 2008

Appl. No.:

12/246068

Inventors:

Jeffery M. Vance - Chapel Hill NC, US
Yi-Ju Li - Durham NC, US
Eden R. Martin - Hillsborough NC, US
William K. Scott - Durham NC, US
Michael A. Hauser - Durham NC, US
Jeffrey M. Stajich - Hillsborough NC, US
Sofia Oliveira - Lisbon, PT
Joelle van der Walt - Raleigh NC, US

International Classification:

C12Q 1/68

US Classification:

435 6

Abstract:

The present invention provides methods and compositions for screening a subject for Parkinson disease, for increased risk of developing Parkinson disease and/or for an earlier or later age of developing Parkinson disease, comprising detecting the presence of a genetic marker associated with Parkinson disease.

US Patent:

20090263801, Oct 22, 2009

Filed:

Jan 2, 2009

Appl. No.:

12/348167

Inventors:

Eric A. Postel - Durham NC, US
Jennifer Caldwell - Durham NC, US
Silke Schmidt - Durham NC, US
Michael Hauser - Durham NC, US

Assignee:

Duke University - Durham NC

International Classification:

C12Q 1/68
G01N 33/535
C12Q 1/02

US Classification:

435 6, 435 792, 435 29

Abstract:

Age-Related Macular Degeneration (AMD) cases possessing the LOC387715 (rs10490924) variant have a higher risk of neovascular AMD. Individuals with AMD who are homozygous for both variants might be at greater risk for earlier onset of neovascular AMD. Determining the presence of this variant indicates which path the disease may take and which nutritional, supplement, or medicaments are appropriate.

US Patent:

20100145223, Jun 10, 2010

Filed:

Nov 12, 2009

Appl. No.:

12/617256

Inventors:

Eric A. Postel - Durham NC, US
R. Keith Shuler - Durham NC, US
Jennifer Vaughn Caldwell - Durham NC, US
Michael Hauser - Durham NC, US
Silke Schmidt - Durham NC, US

Assignee:

DUKE UNIVERSITY - Durham NC

International Classification:

A61B 3/14
A61F 9/00
A61B 3/10

US Classification:

600558, 351206

Abstract:

Examination of 956 age-related macular degeneration cases showed that the complement factor H variant (Y402H, C allele at rs1061170) increases risk for the development of peripheral reticular pigmentary change. AMD phenotypes of 796 carriers of the CFH Y402H variant were compared to the AMD phenotypes of 160 non-carriers. Of 34 phenotypic features analyzed, only peripheral reticular pigmentary change (PRPC) was associated with this CFH variant (P-value 0.0006). The proportion of AMD cases with PRPC correlated with the number of CFH risk C alleles in a dose-response fashion. The association of CFH Y402H polymorphism with PRPC suggests that AMD changes are not limited to the macula. Current AMD grading methods assess only the macula; peripheral retinal changes should also be included in grading methods. PRPC may be used as a surrogate of a high-risk genotype and may be used for diagnostic, therapeutic, and research purposes.

US Patent:

20110183340, Jul 28, 2011

Filed:

Feb 28, 2011

Appl. No.:

13/036780

Inventors:

Eric A. Postel - Durham NC, US
Jennifer Caldwell - Durham NC, US
Silke Schmidt - Durham NC, US
Michael Hauser - Durham NC, US

Assignee:

DUKE UNIVERSITY - Durham NC

International Classification:

C12Q 1/68
G01N 33/53

US Classification:

435 612, 435 61, 435 71, 435 792

Abstract:

Age-Related Macular Degeneration (AMD) cases possessing the LOC387715 (rs 10490924) variant have a higher risk of neovascular AMD. Individuals with AMD who are homozygous for both variants might be at greater risk for earlier onset of neovascular AMD. Determining the presence of this variant indicates which path the disease may take and which nutritional, supplement, or medicaments are appropriate.