Michael Winn Hauser

US Patent:

20060068428, Mar 30, 2006

Filed:

Aug 31, 2005

Appl. No.:

11/216660

Inventors:

Jeffery Vance - Chapel Hill NC, US
Yi-Ju Li - Durham NC, US
Eden Martin - Hillsborough NC, US
William Scott - Durham NC, US
Michael Hauser - Durham NC, US
Jeffrey Stajich - Hillsborough NC, US
Sofia Oliveira - Lisbon, PT
Joelle van der Walt - Raleigh NC, US

International Classification:

C12Q 1/68

US Classification:

435006000

Abstract:

The present invention provides methods and compositions for screening a subject for Parkinson disease, for increased risk of developing Parkinson disease and/or for an earlier or later age of developing Parkinson disease, comprising detecting the presence of a genetic marker associated with Parkinson disease.

US Patent:

20060246437, Nov 2, 2006

Filed:

Jul 11, 2003

Appl. No.:

10/520695

Inventors:

Jeffery Vance - Chapel Hill NC, US
Marcy Speer - Durham NC, US
Michael Hauser - Durham NC, US

International Classification:

C12Q 1/68

US Classification:

435006000

Abstract:

The present invention is directed to a method for diagnosing a subject as being or having a predisposition to being asthmatic. The present invention is also directed to methods of detecting whether a subject may be atopic by screening for genetic risk factors.

US Patent:

20090098557, Apr 16, 2009

Filed:

Oct 6, 2008

Appl. No.:

12/246068

Inventors:

Jeffery M. Vance - Chapel Hill NC, US
Yi-Ju Li - Durham NC, US
Eden R. Martin - Hillsborough NC, US
William K. Scott - Durham NC, US
Michael A. Hauser - Durham NC, US
Jeffrey M. Stajich - Hillsborough NC, US
Sofia Oliveira - Lisbon, PT
Joelle van der Walt - Raleigh NC, US

International Classification:

C12Q 1/68

US Classification:

435 6

Abstract:

The present invention provides methods and compositions for screening a subject for Parkinson disease, for increased risk of developing Parkinson disease and/or for an earlier or later age of developing Parkinson disease, comprising detecting the presence of a genetic marker associated with Parkinson disease.

US Patent:

20090263801, Oct 22, 2009

Filed:

Jan 2, 2009

Appl. No.:

12/348167

Inventors:

Eric A. Postel - Durham NC, US
Jennifer Caldwell - Durham NC, US
Silke Schmidt - Durham NC, US
Michael Hauser - Durham NC, US

Assignee:

Duke University - Durham NC

International Classification:

C12Q 1/68
G01N 33/535
C12Q 1/02

US Classification:

435 6, 435 792, 435 29

Abstract:

Age-Related Macular Degeneration (AMD) cases possessing the LOC387715 (rs10490924) variant have a higher risk of neovascular AMD. Individuals with AMD who are homozygous for both variants might be at greater risk for earlier onset of neovascular AMD. Determining the presence of this variant indicates which path the disease may take and which nutritional, supplement, or medicaments are appropriate.

US Patent:

20100145223, Jun 10, 2010

Filed:

Nov 12, 2009

Appl. No.:

12/617256

Inventors:

Eric A. Postel - Durham NC, US
R. Keith Shuler - Durham NC, US
Jennifer Vaughn Caldwell - Durham NC, US
Michael Hauser - Durham NC, US
Silke Schmidt - Durham NC, US

Assignee:

DUKE UNIVERSITY - Durham NC

International Classification:

A61B 3/14
A61F 9/00
A61B 3/10

US Classification:

600558, 351206

Abstract:

Examination of 956 age-related macular degeneration cases showed that the complement factor H variant (Y402H, C allele at rs1061170) increases risk for the development of peripheral reticular pigmentary change. AMD phenotypes of 796 carriers of the CFH Y402H variant were compared to the AMD phenotypes of 160 non-carriers. Of 34 phenotypic features analyzed, only peripheral reticular pigmentary change (PRPC) was associated with this CFH variant (P-value 0.0006). The proportion of AMD cases with PRPC correlated with the number of CFH risk C alleles in a dose-response fashion. The association of CFH Y402H polymorphism with PRPC suggests that AMD changes are not limited to the macula. Current AMD grading methods assess only the macula; peripheral retinal changes should also be included in grading methods. PRPC may be used as a surrogate of a high-risk genotype and may be used for diagnostic, therapeutic, and research purposes.

US Patent:

20110183340, Jul 28, 2011

Filed:

Feb 28, 2011

Appl. No.:

13/036780

Inventors:

Eric A. Postel - Durham NC, US
Jennifer Caldwell - Durham NC, US
Silke Schmidt - Durham NC, US
Michael Hauser - Durham NC, US

Assignee:

DUKE UNIVERSITY - Durham NC

International Classification:

C12Q 1/68
G01N 33/53

US Classification:

435 612, 435 61, 435 71, 435 792

Abstract:

Age-Related Macular Degeneration (AMD) cases possessing the LOC387715 (rs 10490924) variant have a higher risk of neovascular AMD. Individuals with AMD who are homozygous for both variants might be at greater risk for earlier onset of neovascular AMD. Determining the presence of this variant indicates which path the disease may take and which nutritional, supplement, or medicaments are appropriate.

US Patent:

20130059366, Mar 7, 2013

Filed:

Nov 8, 2010

Appl. No.:

13/508300

Inventors:

Michael G. Pollack - Durham NC, US
Vijay Srinivasan - Durham NC, US
Zhishan Hua - Durham NC, US
Hon Lung Chu - Durham NC, US
Michael Hauser - Durham NC, US
Allen Eckhardt - Durham NC, US

Assignee:

DUKE UNIVERSITY - Durham NC
ADVANCED LIQUID LOGIC, INC. - Research Triangle Park NC

International Classification:

C12M 1/40

US Classification:

4352872

Abstract:

The invention is directed to a droplet actuator device and methods for integrating gel electrophoresis analysis with pre or post-analytical sample handling as well as other molecular analysis processes. Using digital microfluidics technology, the droplet actuator device and methods of the invention provide the ability to perform gel electrophoresis and liquid handling operations on a single integrated device. The integrated liquid handling operations may be used to prepare and deliver samples to the electrophoresis gel, capture and subsequently process products of the electrophoresis gel or perform additional assays on the same sample materials which are analyzed by gel electrophoresis. In one embodiment, one or more molecular assays, such as nucleic acid (e.g., DNA) quantification by real-time PCR, and one or more sample processing operations such as sample dilution is performed on a droplet actuator integrated with an electrophoresis gel. In one embodiment, an electrophoresis gel may be integrated on the top substrate of the droplet actuator.