Michael Ray Knowles

US Patent:

20100292088, Nov 18, 2010

Filed:

May 14, 2010

Appl. No.:

12/780220

Inventors:

Maimoona Banoo Abdul Hamid Zariwala - Chapel Hill NC, US
Michael R. Knowles - Chapel Hill NC, US

International Classification:

C40B 30/02
G01N 33/50
C12Q 1/68
G01N 23/00
G01N 30/00

US Classification:

506 8, 436 94, 435 6, 250307, 73 6152

Abstract:

The present invention provides methods and compositions for detecting mutations in a DNAH11 gene of a subject to diagnose primary ciliary dyskinesia (PCD) in the subject and/or to identify a subject as having an increased risk of having PCD and/or to identify a carrier of a PCD mutation.

US Patent:

45017298, Feb 26, 1985

Filed:

Dec 13, 1982

Appl. No.:

6/449424

Inventors:

Richard C. Boucher - Chapel Hill NC
John T. Gatzy - Chapel Hill NC
Michael R. Knowles - Chapel Hill NC

Assignee:

Research Corporation - New York NY

International Classification:

A61K 31495

US Classification:

424 45

Abstract:

This disclosure describes a method of treatment of retained pulmonary secretions by the use of aerosolized suspension of amiloride.

US Patent:

57258422, Mar 10, 1998

Filed:

Jan 5, 1996

Appl. No.:

8/583671

Inventors:

Richard C. Boucher - Chapel Hill NC
Michael R. Knowles - Chapel Hill NC

Assignee:

The University of North Carolina at Chapel Hill - Chapel Hill NC

International Classification:

A61K 912

US Classification:

424 45

Abstract:

Methods are disclosed for removing retained mucus secretions from the lungs of a human subject. The method includes (1) generating an aerosol suspension of respirable solid, dry particulate amiloride, and (2) delivering by inhalation the aerosol suspension to the respiratory system of the subject. The solid particulate amiloride is comprised of particles of about 1 to 5 microns and is free of liquid amiloride particles. The aerosol suspension of respirable solid particulate amiloride is administered in an amount sufficient to achieve concentrations of amiloride on the airway surfaces of from about 10. sup. -7 to 10. sup. -3 Moles/liter. As a result of the treatment, the secretions are hydrated and more easily transported from the lung via mucociliary action. Methods are also disclosed for the treatment of cystic fibrosis in humans.

US Patent:

56108770, Mar 11, 1997

Filed:

Jan 20, 1995

Appl. No.:

8/375787

Inventors:

Kathy S. Adams - Raleigh NC
Michael J. Knowles - Fayetteville NC

International Classification:

G04B 3700

US Classification:

368 10

Abstract:

This invention is a timepiece mounted within a case with a separate flexible backing that has a plurality of outwardly projecting fingers with upwardly turned lips at the ends thereof. The case is placed on a piece of fabric such as the sleeve of a shirt. The backing is placed on the other side of the fabric with the stem of the timepiece outwardly projecting between the fingers of the base portion. By pressing the base portion and the timepiece case together grips the fabric to mount the timepiece on such fabric. The timepiece can be removed from the fabric by simply pressing at least part of the lips outwardly to disengage the same through the fabric from the case within the timepiece is mounted.