Michael R Knowles

US Patent:

8028880, Oct 4, 2011

Filed:

Jul 11, 2008

Appl. No.:

12/172065

Inventors:

Michael Knowles - Los Angeles CA, US

International Classification:

B65D 25/10
A45F 3/08
A47F 5/00

US Classification:

224637, 224242, 224262, 248351

Abstract:

Provided are, among other things, apparatuses for supporting a video camera. In one embodiment, the apparatus includes: a harness adapted for wearing on a user's upper body, the harness including a front section which, in use, covers at least a portion of at least one of the user's chest and abdomen, and a rear section which, in use, covers at least a portion of the user's back; and a flexible rod having a proximal end secured to the rear section of the harness and a distal end that extends up above the harness when the flexible rod is unweighted.

US Patent:

20090162855, Jun 25, 2009

Filed:

Nov 3, 2008

Appl. No.:

12/264165

Inventors:

Mitchell Drumm - Brecksville OH, US
Rebecca Darrah - Strongsville OH, US
Paul Smith - Mayfield Village OH, US
Steven Martin - Shawnee KS, US
Michael Knowles - Chapel Hill NC, US
Steven Strausbaugh - Novelty OH, US
Robert Schilz - Shaker Heights OH, US

Assignee:

CASE WESTERN RESERVE UNIVERSITY - Cleveland OH

International Classification:

C12Q 1/68

US Classification:

435 6

Abstract:

A method of determining a genetic component contributing to the severity of a pulmonary disease in a patient comprises determining the presence or absence of one or more single nucleotide polymorphisms (SNPs) in the Endothelin Receptor A (EDNRA) gene or the Interleukin-8 (IL-8) gene of the patient. The SNPs are rs5335 or rs1801708 for EDNRA, or rs4O73 for IL-8. The pulmonary disease may be cystic fibrosis or lymphangioleimyomatosis. Determining the presence or absence of one or more of SNPs rs5335 or rs1801708 in the EDNRA gene or rs4073 in the IL-8 gene of the patient may also be used in a method of treating a patient having a pulmonary disease. A kit may comprise one or more probes for determining the presence or absence of one or more of SNPs rs5335 and rs1801708 in the EDNRA gene or the SNP rs4073 in the IL-8 gene.

US Patent:

20100292088, Nov 18, 2010

Filed:

May 14, 2010

Appl. No.:

12/780220

Inventors:

Maimoona Banoo Abdul Hamid Zariwala - Chapel Hill NC, US
Michael R. Knowles - Chapel Hill NC, US

International Classification:

C40B 30/02
G01N 33/50
C12Q 1/68
G01N 23/00
G01N 30/00

US Classification:

506 8, 436 94, 435 6, 250307, 73 6152

Abstract:

The present invention provides methods and compositions for detecting mutations in a DNAH11 gene of a subject to diagnose primary ciliary dyskinesia (PCD) in the subject and/or to identify a subject as having an increased risk of having PCD and/or to identify a carrier of a PCD mutation.

US Patent:

20130274132, Oct 17, 2013

Filed:

Sep 30, 2011

Appl. No.:

13/876712

Inventors:

Lisa Strug - Toronto, CA
Lei Sun - Toronto, CA
Johanna M. Rommens - Toronto, CA
Garry Cutting - Towson MD, US
Michael Knowles - Chapel Hill NC, US
Mitchell L. Drumm - Brecksville OH, US
Peter Durie - Toronto, CA

Assignee:

Hospital for Sick Children - Toronto ON
Case Western Reserve University - Cleveland OH
Univeristy of North Carolina at Chapet Hill - Chapel Hill NC
The Johns Hopkins University - Baltimore MD

International Classification:

C12Q 1/68

US Classification:

506 9, 435 611

Abstract:

Disclosed herein are compositions and methods for and treating Cystic Fibrosis lung disease severity and/or secondary manifestations, including meconium ileus and CF related liver disease.

US Patent:

45017298, Feb 26, 1985

Filed:

Dec 13, 1982

Appl. No.:

6/449424

Inventors:

Richard C. Boucher - Chapel Hill NC
John T. Gatzy - Chapel Hill NC
Michael R. Knowles - Chapel Hill NC

Assignee:

Research Corporation - New York NY

International Classification:

A61K 31495

US Classification:

424 45

Abstract:

This disclosure describes a method of treatment of retained pulmonary secretions by the use of aerosolized suspension of amiloride.

US Patent:

57258422, Mar 10, 1998

Filed:

Jan 5, 1996

Appl. No.:

8/583671

Inventors:

Richard C. Boucher - Chapel Hill NC
Michael R. Knowles - Chapel Hill NC

Assignee:

The University of North Carolina at Chapel Hill - Chapel Hill NC

International Classification:

A61K 912

US Classification:

424 45

Abstract:

Methods are disclosed for removing retained mucus secretions from the lungs of a human subject. The method includes (1) generating an aerosol suspension of respirable solid, dry particulate amiloride, and (2) delivering by inhalation the aerosol suspension to the respiratory system of the subject. The solid particulate amiloride is comprised of particles of about 1 to 5 microns and is free of liquid amiloride particles. The aerosol suspension of respirable solid particulate amiloride is administered in an amount sufficient to achieve concentrations of amiloride on the airway surfaces of from about 10. sup. -7 to 10. sup. -3 Moles/liter. As a result of the treatment, the secretions are hydrated and more easily transported from the lung via mucociliary action. Methods are also disclosed for the treatment of cystic fibrosis in humans.

US Patent:

20190232345, Aug 1, 2019

Filed:

Feb 1, 2018

Appl. No.:

15/886525

Inventors:

- Graham NC, US
Michael Scott Knowles - Graham NC, US

Assignee:

Petroleum Tec - Graham NC

International Classification:

B08B 9/08
B08B 3/02
B67D 7/62
B67D 7/78

Abstract:

The invention describes three compartments for cleaning and dispensing fuel and cleaning out fuel storage tanks with a minimum of down time.