Michael John Rice

US Patent:

8137269, Mar 20, 2012

Filed:

Mar 15, 2007

Appl. No.:

11/724642

Inventors:

Hamid Sheikhzadeh-Nadjar - Waterloo, CA
Robert L. Brennan - Kitchener, CA
Michael Rice - Woodinville WA, US

Assignee:

On Semiconductor Trading Ltd. - Hamilton

International Classification:

A61B 5/00

US Classification:

600300, 600301

Abstract:

A method and system for managing physiological systems is provided. The physiological system management (PSM) system includes one or more signal acquisition blocks to collect physiological information. The PSM system includes oversampled filterbanks for transferring one or more input signal related to the physiological information into subband signals, and a subband processing scheme for processing the outputs from the oversampled filterbanks for event detection in one or more physiological systems. The PSM system includes an adaptive controller which decides on the proper control measure and delivers the measure to the one or more physiological systems.

US Patent:

8642255, Feb 4, 2014

Filed:

Mar 27, 2009

Appl. No.:

12/934644

Inventors:

Ian B. Nicoud - Seattle WA, US
Dominic M. Clarke - Bothell WA, US
Aby J. Mathew - Vestal NY, US
Michael Rice - Woodinville WA, US

Assignee:

Biolife Solutions, Inc. - Bothell WA

International Classification:

A01N 1/02

US Classification:

435 2

Abstract:

The present invention relates to materials and methods for hypothermic collection of whole blood, and components thereof, which can extend the holding time of blood beyond the current useable limit. Additionally, blood can be drawn directly into a hypothermic preservation solution without the addition of standard anticoagulants. This is enabled by providing sustained cellular viability under hypothermic conditions using a nutrient matrix devoid of animal proteins and containing energy substrates, free-radical scavengers, and impermeants that is ionically balanced for storage of biologic materials at low temperatures to prevent cellular stress-induced apoptosis.

US Patent:

20120040450, Feb 16, 2012

Filed:

Apr 29, 2010

Appl. No.:

13/265959

Inventors:

Dominic M. Clarke - Bothell WA, US
Ian B. Nicoud - Seattle WA, US
Aby J. Mathew - Bothell WA, US
Michael Rice - Woodinville WA, US

Assignee:

BIOLIFE SOLUTIONS, INC. - Bothell WA

International Classification:

C12M 1/00

US Classification:

4353071

Abstract:

Provided are apparatuses for cryopreserving cells which include a vessel comprising a biocompatible substrate, wherein the vessel further comprises an interior and an exterior, and a mechanical ice nucleating device disposed in or on the vessel interior for initiating ice crystal formation. Also provided are kits comprising one or more apparatuses for cryopreserving cells and a biopreservation medium. Further provided are compositions comprising a vessel for holding cells, a mechanical ice nucleating device, a biopreservation medium, and cells disposed in the vessel. The apparatuses, kits, and compositions of the invention can optionally include an insulating material which is disposed on all or a portion of the vessel.

US Patent:

20140322698, Oct 30, 2014

Filed:

Feb 2, 2014

Appl. No.:

14/170637

Inventors:

- Bothell WA, US
Dominic M. Clarke - Bothell WA, US
Aby J. Matthew - Vestal NY, US
Michael Rice - Woodinville WA, US

Assignee:

BIOLIFE SOLUTIONS, INC. - Bothell WA

International Classification:

C12N 5/078

US Classification:

435 2

Abstract:

The present invention relates to materials and methods for hypothermic collection of whole blood, and components thereof, which can extend the holding time of blood beyond the current usable limit. Additionally, blood can be drawn directly into a hypothermic preservation solution without the addition of standard anticoagulants. This is enabled by providing sustained cellular viability under hypothermic conditions using a nutrient matrix devoid of animal proteins and containing energy substrates, free-radical scavengers, and impermeants that is ionically balanced for storage of biologic materials at low temperatures to prevent cellular stress-induced apoptosis.