Michael H Weiner

US Patent:

20020042137, Apr 11, 2002

Filed:

Jul 11, 2001

Appl. No.:

09/903452

Inventors:

Cynthia Richards - Durham NC, US
Michael Weiner - Cary NC, US

International Classification:

C12N015/861
C07H021/04
C12N007/01

US Classification:

435/456000, 435/235100, 536/023720

Abstract:

The present invention provides a system for simple generation of recombinant animal viruses. The system includes a virus homing vector and can further comprise a transfer vector. These components are used in a system that reduces the number of cloning steps and provides for easier preparation of a number of recombinant viruses.

US Patent:

20020142345, Oct 3, 2002

Filed:

Dec 22, 2000

Appl. No.:

09/747003

Inventors:

Anita Nelsen - Raleigh NC, US
Lottie Peppers - Apex NC, US
Michael Weiner - Cary NC, US

International Classification:

C12Q001/68
G01N033/53
G06F019/00

US Classification:

435/007100, 435/006000, 702/019000

Abstract:

The present invention provides a method of encoding a complex mixture of assay constituents comprising using combinations of detectable tags and a total number of detectable tags that is less than the total number of constituents to be encoded. More specifically, the method further comprises determining the total number of constituents to be encoded; determining the number of detectable tags in each combination, wherein the number of detectable tags in each combination is more than one and less than or equal to the number of prime numbers in the number of constituents to be encoded; and determining the total number of detectable tags, wherein the total number of detectable tags equals a sum of a set of factors of the total number of constituents, wherein the number of factors equals the number of detectable tags in each combination. The invention further provides using the encoding methods in a method of performing a multiplexed assay using complex mixtures of assay constituents and a kit for performing the multiplexed assay using complex mixtures of encoded assay constituents.

US Patent:

20020187470, Dec 12, 2002

Filed:

Dec 21, 2000

Appl. No.:

09/745317

Inventors:

Warren Casey - Knightdale NC, US
Jingwen Chen - Morrisville NC, US
Heidi Colton - Apex NC, US
David Taylor - Hillsborough NC, US
Michael Weiner - Cary NC, US

International Classification:

C12Q001/68

US Classification:

435/006000

Abstract:

Provided is a method of identifying a selected nucleotide in a first nucleic acid utilizing a mobile solid support, as well as a novel read-out method for improving the use of mobile solid support-based read-out technologies for detection of nucleic acid polymorphisms in a target nucleic acid.

US Patent:

20030170623, Sep 11, 2003

Filed:

Apr 13, 2001

Appl. No.:

09/834470

Inventors:

Jingwen Chen - Durham NC, US
Michael Weiner - Cary NC, US
Fei Ye - Apex NC, US

International Classification:

C12Q001/68

US Classification:

435/006000

Abstract:

The present invention relates to methods and kits for identifying and quantifying target nucleic acids in an array of assay samples using distinguishably labeled microspheres and a detecting means, such as flow cytometry. The methods and kits can be used in a multiplexed format to provide a highly sensitive, low cost, high-throughput assay of many targets simultaneously without the spatial constraints of a fixed array

US Patent:

20030232341, Dec 18, 2003

Filed:

Jun 12, 2002

Appl. No.:

10/170332

Inventors:

Warren Casey - Durham NC, US
Jingwen Chen - Durham NC, US
Heidi Colton - Durham NC, US
James Taylor - Durham NC, US
Michael Weiner - Branford CT, US

International Classification:

C12Q001/68

US Classification:

435/006000

Abstract:

Provided is a method of identifying a selected nucleotide in a first nucleic acid utilizing a mobile solid support, as well as a novel read-out method for improving the use of mobile solid support-based read-out technologies for detection of nucleic acid polymorphisms in a target nucleic acid.

US Patent:

20070098407, May 3, 2007

Filed:

Sep 20, 2006

Appl. No.:

11/533667

Inventors:

Jack Hebrank - Durham NC, US
Charles Hunter - Jefferson NC, US
Michael Weiner - New York NY, US
Robert Davis - Raleigh NC, US
Laurie McNeil - Chapel Hill NC, US

Assignee:

Next Safety, Inc. - Jefferson NC

International Classification:

H04B 10/00

US Classification:

398106000

Abstract:

Communication methods and apparatus using ultraviolet (UV) light are provided. Save UV communication devices, including remote control units, can use highly efficient UV LEDs and very low-noise UV photodetectors. In some cases, the LEDs emit light at wavelengths below 400 nm, below 320 nm, or even below 280 nm. In one embodiment, communication can be achieved using an LED that emits less than about 1 picowatt of UV energy at a photodetector distance of up to at least about 10 meters. Longer range communication can also be achieved at higher power levels. Photodetectors having very low dark currents at room temperature, such as below about 1×10A/m, are preferable.

US Patent:

62912143, Sep 18, 2001

Filed:

May 10, 1999

Appl. No.:

9/309382

Inventors:

Cynthia Ann Richards - Durham NC
Michael Phillip Weiner - Cary NC

Assignee:

Glaxo Wellcome Inc. - Research Triangle Park NC

International Classification:

C12N 1564
C12N 502
C12N 1563
C12N 121
C12N 119

US Classification:

435 914

Abstract:

The present invention provides a system for simple generation of recombinant animal viruses. The system includes a virus homing vector and can further comprise a transfer vector. These components are used in a system that reduces the number of cloning steps and provides for easier preparation of a number of recombinant viruses.

US Patent:

63328976, Dec 25, 2001

Filed:

Mar 27, 1998

Appl. No.:

9/049325

Inventors:

Michael Phillip Weiner - Cary NC
Richard Gordon Buckholz - Cary NC

Assignee:

Glaxo Wellcome Inc. - Research Triangle Park NC

International Classification:

C12Q 168
C12N 1564

US Classification:

735 6

Abstract:

The present invention relates to an automated format for the yeast two hybrid assay for protein-protein interactions.