Michael Alan Weiner

US Patent:

55232213, Jun 4, 1996

Filed:

Jun 16, 1993

Appl. No.:

8/078662

Inventors:

Michael P. Weiner - San Diego CA

Assignee:

Stratagene - La Jolla CA

International Classification:

C12N 1511
C12N 1566

US Classification:

4351723

Abstract:

A method for directionally cloning an insert DNA fragment into a target sequence using differential phosphorylation is disclosed, Monophosphorylated PCR fragments are directionally cloned into a monophosphorylated plasmid, Methods for directionally cloning non-PCR fragments into target DNA sequences are also discussed.

US Patent:

55999212, Feb 4, 1997

Filed:

May 8, 1991

Appl. No.:

7/697936

Inventors:

Joseph A. Sorge - Rancho Santa Fe CA
Dan Shoemaker - Del Mar CA
Michael Weiner - San Diego CA

Assignee:

Stratagene - La Jolla CA

International Classification:

C07H 2100
C07H 2104

US Classification:

536 2433

Abstract:

A composition comprising a family of oligonucleotides all of the same length, said family defined by a nucleotide sequence formula containing six to eight nucleotide positions, one to three of said positions of the formula identifying positions of nucleotide variation among the family members, the remaining nucleotide positions each identifying a nucleotide that is the same in all members of the family.

US Patent:

20230054691, Feb 23, 2023

Filed:

Aug 9, 2022

Appl. No.:

17/818616

Inventors:

- San Diego CA, US
Kevin L. Gunderson - San Diego CA, US
Michael Phillip Weiner - San Diego CA, US

Assignee:

Encodia, Inc. - San Diego CA

International Classification:

G01N 33/68
C40B 40/10
C40B 70/00

Abstract:

A method for analyzing macromolecules, including peptides, polypeptides, and proteins, employing nucleic acid encoding is disclosed.

US Patent:

20210405058, Dec 30, 2021

Filed:

Aug 27, 2021

Appl. No.:

17/460138

Inventors:

- San Diego CA, US
Kevin L. GUNDERSON - San Diego CA, US
Michael Phillip Weiner - San Diego CA, US

Assignee:

Encodia, Inc. - San Diego CA

International Classification:

G01N 33/68
C40B 70/00

Abstract:

A method for analyzing macromolecules, including peptides, polypeptides, and proteins, employing nucleic acid encoding is disclosed.

US Patent:

20210396762, Dec 23, 2021

Filed:

Jun 15, 2021

Appl. No.:

17/348643

Inventors:

- San Diego CA, US
Michael Phillip WEINER - San Diego CA, US

Assignee:

Encodia, Inc. - San Diego CA

International Classification:

G01N 33/68
G01N 33/58

Abstract:

The present disclosure relates to methods and kits for analysis of peptides, polypeptides and proteins, employing a multi-component detection agent(s). In some embodiments, the method is useful for identifying the terminal amino acid of the peptide. In some embodiments, the multi-component detection agent includes a first detection agent and second detection agent which, when in proximity, is capable of generating a detectable signal.

US Patent:

20210355483, Nov 18, 2021

Filed:

Oct 31, 2018

Appl. No.:

16/760032

Inventors:

- San Diego CA, US
Kevin GUNDERSON - San Diego CA, US
Michael Phillip WEINER - San Diego CA, US
Lei SHI - San Diego CA, US
Norihito MURANAKA - San Diego CA, US

Assignee:

Encodia, Inc. - San Diego CA

International Classification:

C12N 15/10
C12Q 1/6804
G01N 33/68

Abstract:

Methods and Kits for analyzing macromolecules, including peptides, polypeptides, and proteins, employing nucleic acid encoding are disclosed. The sample analysis kits employ nucleic acid encoding and/or nucleic acid recording of a molecular interaction and/or reaction, such as recognition events (e.g., between an antigen and an antibody, between a modified terminal amino acid residue, or between a small molecule or peptide therapeutic and a target, etc.). Assays that do not require the cyclic transfer of information between a coding tag and a recording tag are also disclosed, including single cycle assays.

US Patent:

20210302431, Sep 30, 2021

Filed:

Mar 10, 2021

Appl. No.:

17/197796

Inventors:

- San Diego CA, US
Kevin L. GUNDERSON - San Diego CA, US
Michael Phillip Weiner - San Diego CA, US

Assignee:

Encodia, Inc. - San Diego CA

International Classification:

G01N 33/68
C40B 70/00

Abstract:

A method for analyzing macromolecules, including peptides, polypeptides, and proteins, employing nucleic acid encoding is disclosed.

US Patent:

20200348308, Nov 5, 2020

Filed:

Oct 31, 2018

Appl. No.:

16/760028

Inventors:

- San Diego CA, US
John M BEIERLE - San Diego CA, US
Norihito MURANAKA - San Diego CA, US
Kevin GUNDERSON - San Diego CA, US
Michael Phillip WEINER - San Diego CA, US
Lei SHI - San Diego CA, US
Robert C. JAMES - San Diego CA, US
Luca MONFREGOLA - San Diego CA, US

Assignee:

Encodia, Inc. - San Diego CA

International Classification:

G01N 33/68
C40B 40/10
C40B 70/00

Abstract:

Kits and methods of using the kits for analyzing macromolecules, including peptides, polypeptides, and proteins, employing nucleic acid encoding are disclosed. The sample analysis kits employ nucleic acid encoding and/or nucleic acid recording of a molecular interaction and/or reaction, such as recognition events (e.g., between an antigen and an antibody, between a modified terminal amino acid residue, or between a small molecule or peptide therapeutic and a target, etc.). Additional barcoding reagents, such as those for cycle-specific barcoding (e.g., “clocking”), compartment barcoding, combinatorial barcoding, spatial barcoding, or any combination thereof, may be included in the kits. The sample may comprise macromolecules, including peptides, polypeptides, and proteins, and the recording may generate molecular interaction and/or reaction information, and/or polypeptide sequence information. The kits may be used in high-throughput, multiplexed, and/or automated analysis, and are suitable for analysis of a proteome or subset thereof.