Milan R Uskokovic

US Patent:

6452028, Sep 17, 2002

Filed:

Aug 25, 2000

Appl. No.:

09/648825

Inventors:

Andrew David Batcho - North Caldwell NJ
Bernard Michael Hennessy - Nutley NJ
Jerome Anthony Iacobelli - Paramus NJ
Milan Radoje Uskokovic - Upper Montclair NJ

Assignee:

Hoffmann-La Roche Inc. - Nutley NJ

International Classification:

C07C40100

US Classification:

552653, 514167

Abstract:

A compound of the formula wherein R is hydrogen or hydroxy, each R is ethyl, propyl, butyl, isopropyl or t-butyl, X is CH , or when R is hydroxy, X is hydrogen or CH , and A is âCâCâ, or âCH âCH â. These compounds are useful for the treatment of hyperproliferative disorders, skin diseases, and sebaceous gland diseases.

US Patent:

6492353, Dec 10, 2002

Filed:

Sep 3, 1998

Appl. No.:

09/148018

Inventors:

Percy Sarwood Manchand - Montclair NJ
Milan Radoje Uskokovic - Upper Montclair NJ

Assignee:

Syntex LLC - Palo Alto CA
Hoffmann-La Roche Inc. - Nutley NJ

International Classification:

C07C40101

US Classification:

514167, 552653

Abstract:

This invention relates to 1,3-dihydroxy-20,20-dialkyl-vitamin D analogs of Formula (I): compositions comprising the analogs, methods of preparing the analogs and methods of treatment of osteoporosis, secondary hyperparathyroidism, cancer and autoimmune diseases using such analogs.

US Patent:

6559138, May 6, 2003

Filed:

Sep 18, 2002

Appl. No.:

10/246333

Inventors:

Milan Radoje Uskokovic - Upper Montclair NJ

Assignee:

Syntex (U.S.A.) LLC - Palo Alto CA

International Classification:

A61K 31593

US Classification:

514167, 552653

Abstract:

The present invention provides 3-desoxy vitamin D analog esters of the formula: and methods for use and preparation of the same, wherein the dotted line, R , R , R , R and L are those defined herein.

US Patent:

7491711, Feb 17, 2009

Filed:

Sep 18, 2002

Appl. No.:

10/246359

Inventors:

Milan Radoje Uskokovic - Upper Montclair NJ, US

Assignee:

Roche Palo Alto LLC - Palo Alto CA

International Classification:

A01N 45/00
C07C 401/00

US Classification:

514167, 552653

Abstract:

The present invention provides a method for treating osteoporosis, hyperparathyroidism or an autoimmune disease in a patient by administering to the patient a 3-desoxy vitamin Danalog of the formula:.

US Patent:

20010007907, Jul 12, 2001

Filed:

May 15, 1998

Appl. No.:

09/080026

Inventors:

SATYANARAYANA G. REDDY - BARRINGTON RI, US
MILAN USKOKOVIC - UPPER MONTCLAIR NJ, US

Assignee:

WOMEN AND INFANTS HOSPITAL

International Classification:

C 07C 4 1/00

US Classification:

552/653000

Abstract:

Novel 3-epi vitamin Dcompounds having the orientation of the substituent attached to the carbon at position 3 of the A-ring of vitamin Dinverted from a beta () to an alpha () configuration are described. These 3-epi vitamin Dcompounds were first identified as metabolites produced via a novel tissue-specific metabolic pathway which catalyzes the 3--hydroxy epimerization of vitamin Dcompounds. Isolated 3-epimer forms of vitamin Dcompounds have been characterized and shown to have improved biological properties compared to their isomeric counterparts, such as reduced hypercalcemic activity and enhanced stability in vivo. The vitamin Dcompounds of the present invention can be used as substitutes for natural and synthetic vitamin Dcompounds.

US Patent:

20030083319, May 1, 2003

Filed:

Jul 25, 2002

Appl. No.:

10/206430

Inventors:

Percy Manchand - Montclair NJ, US
Milan Uskokovic - Upper Montclair NJ, US

Assignee:

Hoffmann-La Roche Inc. - Nutley NJ

International Classification:

C07C401/00
A61K031/59

US Classification:

514/167000, 552/653000

Abstract:

This invention relates to 1,3-dihydroxy-20,20-dialkyl-vitamin D3 analogs of Formula (I): compositions comprising the analogs, methods of preparing the analogs and methods of treatment of osteoporosis, secondary hyperparathyroidism, cancer and autoimmune diseases using such analogs.

US Patent:

20030171605, Sep 11, 2003

Filed:

Sep 9, 2002

Appl. No.:

10/238911

Inventors:

Satyanarayana Reddy - Barrington RI, US
Milan Uskokovic - Upper Montclair NJ, US

Assignee:

Women and Infants Hospital - Providence RI

International Classification:

A61K031/59
C07C401/00

US Classification:

552/653000, 514/167000

Abstract:

Novel 3-epi vitamin Dcompounds having the orientation of the substituent attached to the carbon at position 3 of the A-ring of vitamin Dinverted from a beta () to an alpha () configuration are described. These 3-epi vitamin Dcompounds were first identified as metabolites produced via a novel tissue-specific metabolic pathway which catalyzes the 3--hydroxy epimerization of vitamin Dcompounds. Isolated 3-epimer forms of vitamin Dcompounds have been characterized and shown to have improved biological properties compared to their isomeric counterparts, such as reduced hypercalcemic activity and enhanced stability in vivo. The vitamin Dcompounds of the present invention can be used as substitutes for natural and synthetic vitamin Dcompounds.

US Patent:

20040167105, Aug 26, 2004

Filed:

Feb 18, 2004

Appl. No.:

10/781120

Inventors:

Percy Manchand - Montclair NJ, US
Milan Uskokovic - Upper Montclair NJ, US

International Classification:

A61K031/59
C07C401/00

US Classification:

514/167000, 552/653000

Abstract:

This invention relates to 1,3-dihydroxy-20,20-dialkyl-vitamin Danalogs of Formula (I): compositions comprising the analogs, methods of preparing the analogs and methods of treatment of osteoporosis, secondary hyperparathyroidism, cancer and autoimmune diseases using such analogs.