Min Un Lee

US Patent:

6943167, Sep 13, 2005

Filed:

Aug 29, 2002

Appl. No.:

10/230974

Inventors:

Vincent Huber - Seattle WA, US
Jan Urban - San Diego CA, US
Hiroshi Nakanishi - San Diego CA, US
Masakatsu Eguchi - Bellevue WA, US
Jessymol Mathew - Cary NC, US
Min Sang Lee - Carlsbad CA, US

Assignee:

Myriad Genetics, Inc. - Salt Lake City UT

International Classification:

C07D473/00
A61K031/495

US Classification:

5142521, 544271

Abstract:

Compounds which mimic the secondary structure of helical regions of biologically active peptides and proteins having the following structure: including pharmaceutically acceptable salts and stereoisomers thereof, wherein Y, A, B, Rand Rare as defined herein. Such compounds have utility over a wide range of applications, including use as diagnostic and therapeutic agents. In particular, compounds of this invention, and pharmaceutical compositions containing the same, are neurokinin (tachykinin) antagonists. Libaries contaning the compounds of this invention are also disclosed, as well as methods for screening such libaries identify biologically active members.

US Patent:

7008941, Mar 7, 2006

Filed:

May 16, 2002

Appl. No.:

10/150481

Inventors:

Jan Urban - Kirkland WA, US
Hiroshi Nakanishi - Newcastle WA, US
Min S. Lee - Sammamish WA, US

Assignee:

Myriad Genetics, Inc. - Salt Lake City UT

International Classification:

G01N 33/53
G08D 498/04

US Classification:

5142242, 514249, 514250, 5142305, 435 71, 436518, 544 14, 544 95, 544345, 544350

Abstract:

Conformationally constrained compounds which mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins having the following structure are disclosed: wherein A, B, X, R, and Rare as defined herein. Such compounds have utility over a wide range of fields, including use as diagnostic and therapeutic agents. In particular, compounds of this invention are useful in pharmaceutical compositions as anti-inflammatory agents as well as inhibitors of central nervous disorders. Libraries containing the compounds of this invention are also disclosed, as well as methods for screening the same to identify biologically active members.

US Patent:

7405212, Jul 29, 2008

Filed:

May 3, 2005

Appl. No.:

11/121337

Inventors:

Vincent Huber - Seattle WA, US
Jan Urban - San Diego CA, US
Hiroshi Nakanishi - San Diego CA, US
Masakatsu Eguchi - Bellevue WA, US
Jessymol Mathew - Cary NC, US
Min Sang Lee - Carlsbad CA, US

Assignee:

Myriad Genetics, Inc. - Salt Lake City UT

International Classification:

C07D 498/08
C07D 263/00

US Classification:

5142342, 514249, 544145, 544350

Abstract:

Compounds which mimic the secondary structure of helical regions of biologically active peptides and proteins having the following structure:.

US Patent:

20060079517, Apr 13, 2006

Filed:

Dec 2, 2005

Appl. No.:

11/292611

Inventors:

Jan Urban - Kirkland WA, US
Hiroshi Nakanishi - Newcastle WA, US
Min Lee - Sammamish WA, US

Assignee:

Myriad Genetics, Incorporated - Salt Lake City UT

International Classification:

A61K 31/5415
A61K 31/498

US Classification:

514224200, 514249000

Abstract:

Conformationally constrained compounds which mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins having the following structure are disclosed: wherein A, B, X, R, and Rare as defined herein. Such compounds have utility over a wide range of fields, including use as diagnostic and therapeutic agents. In particular, compounds of this invention are useful in pharmaceutical compositions as anti-inflammatory agents as well as inhibitors of central nervous disorders. Libraries containing the compounds of this invention are also disclosed, as well as methods for screening the same to identify biologically active members.