Ming Yan Cheng

US Patent:

63165902, Nov 13, 2001

Filed:

Nov 8, 2000

Appl. No.:

9/707980

Inventors:

Geoffrey W. Coates - Ithaca NY
Ming Cheng - Oakdale MN
Bradley M. Chamberlain - Ithaca NY

Assignee:

Cornell Research Foundation, Inc. - Ithaca NY

International Classification:

C08G 6382
B01J 3100

US Classification:

528357

Abstract:

Isotactic poly ((R)-lactic acid) or isotactic poly (S)-lactic acid are respectively prepared from (R,R)-lactide and (S,S)-lactide using a catalyst which has a zinc center or a magnesium center and two ligands where one of the ligands is a propagating group and the other of the ligands is not a propagating group. Heterotactic poly(lactic acid) is prepared from rac-lactide using a catalyst which has a zinc center and two ligands where one of the ligands is a propagating group and the other of the ligands is not a propagating group; heterotactic poly(lactic acid) is a novel composition. The catalyst with a magnesium center is a novel catalyst. Syndiotactic poly(lactic acid) is prepared from meso-lactide using a syndiotactic poly(lactic acid) effecting catalyst which has a zinc center and two ligands where one of the ligands is a propagating group and the other of the ligands is not a propagating group and the preferred catalyst contains as the ligand which is not a propagating group diiminate substituted with isopropyl substituted phenyl and the propagating group is isopropoxide. Atactic poly(lactic acid) of polydispersity ranging from 1. 15 to 1. 40 is prepared in less than 10 minutes by polymerizing rac-lactide in the presence of C. sub. 1 -C. sub.

US Patent:

61334022, Oct 17, 2000

Filed:

Jun 9, 1999

Appl. No.:

9/328441

Inventors:

Geoffrey W. Coates - Ithaca NY
Ming Cheng - Ithaca NY

Assignee:

Cornell Research Foundation, Inc. - Ithaca NY

International Classification:

C08G 6302

US Classification:

528196

Abstract:

Polycarbonates having M. sub. n ranging from about 5,000 to about 40,000 and a molecular weight distribution ranging from 1. 05 to 2. 0 are prepared from epoxides and CO. sub. 2 using a catalyst which has a Zn center and two ligands where one of the ligands is a propagating group and the other of the ligands is not a propagating group and an activity of at least one turnover per hour, preferably at least 100 turnovers per hour. Preferred catalysts have a ##STR1## moiety with group on each nitrogen containing a phenyl moiety.

US Patent:

20170342151, Nov 30, 2017

Filed:

Nov 12, 2015

Appl. No.:

15/526309

Inventors:

- New York NY, US
- Boston MA, US
Ming Cheng - New York NY, US

Assignee:

Memorial Sloan Kettering Cancer Center - New York NY
The General Hospital Corporation - Boston MA

International Classification:

C07K 16/28
C07K 16/44
C07K 16/30
A61K 39/00

Abstract:

Described herein are antibodies that bind chondroitin sulfate proteoglycan 4 (CSPG4) and, in particular, chimeric and humanized anti-CSPG4 antibodies and fragments thereof. Also provided herein are methods of using individual humanized antibodies or compositions thereof for the detection, prevention, and/or therapeutic treatment of CSPG4-related diseases, in particular, melanoma.