Ming Tock Cheng

US Patent:

20200023001, Jan 23, 2020

Filed:

Jul 19, 2019

Appl. No.:

16/517274

Inventors:

- Boston MA, US
Solomon A. Mensah - Malden MA, US
Ming Cheng - Boston MA, US
Ronodeep Mitra - Boston MA, US

International Classification:

A61K 31/737
A61K 31/661
A61K 9/00
A61P 9/10

Abstract:

Provided herein are compositions comprising heparan sulfate, or a pharmaceutically acceptable salt thereof, and sphingosine-1-phosphate, or a pharmaceutically acceptable salt thereof. Such compositions are useful in a variety of methods, including methods of regenerating endothelial glycocalyx, preventing endothelial glycocalyx degradation and treating vascular disease.

US Patent:

20180127503, May 10, 2018

Filed:

Mar 10, 2016

Appl. No.:

15/555036

Inventors:

- Emeryville CA, US
- New York NY, US
Pei WANG - Union City CA, US
Nai-Kong CHEUNG - Purchase NY, US
Hongfen GUO - Forest Hills NY, US
Ming CHENG - Roosevelt Island NY, US

International Classification:

C07K 16/28
C07K 16/22
A61K 47/68
A61P 35/00

Abstract:

The invention relates to antibodies, and in particular, to antibodies exhibiting specificity for Receptor tyrosine kinase-like Orphan Receptors (ROR), and to uses thereof for example in the treatment of cancer. The invention extends to polynucleotide and polypeptide sequences encoding the antibodies, and therapeutic uses thereof, and to diagnostic kits comprising these molecules. The invention also extends to antibody-drug conjugates and to uses thereof in therapy.