The present invention provides methods and kits for identifying a cell that exhibits or is predisposed to exhibiting unregulated growth by detecting hypermethylation of a gene or a regulatory region in at least one gene in the cell. Also provided are methods for diagnosis or prognosis of ovarian cancer in a subject. Also provided are methods of ameliorating ovarian cancer in a subject by administering to the subject an agent that demethylates a hypermethylated gene or regulatory region thereof.
Methods Of Detection And Treatment Of Urothelial Cancer
- Baltimore MD, US Leonel Francisco Maldonado Gonzalez - Baltimore MD, US Mariana Brait Rodrigues De Oliveira - Baltimore MD, US Mohammad O. Hoque - Towson MD, US
The invention provides methods for detecting a cellular proliferative disorder (e.g., urothelial cancer) in a subject by assessing the methylation status of the CCND2, CCNA1 or CALCA promoter in a nucleic acid sample. The methods of the invention are useful for diagnostic, prognostic as well therapeutic regimen predictions.
Urothelial Cancer And Methods Of Detection And Targeted Therapy
- Baltimore MD, US Elisa Guida - Baltimore MD, US Mohammad Hoque - Baltimore MD, US
International Classification:
C12Q 1/68 A61K 31/706
Abstract:
The invention provides methods for detecting a cellular proliferative disorder (e.g., urothelial cancer) in a subject by assessing the methylation status of the GULP1 promoter in a nucleic acid sample. The methods of the invention are useful for diagnostic, prognostic as well as therapeutic regimen predictions.
Medical School - Dhaka Medical College Howard University Hospital, Internship in Internal Medicine Howard University Hospital, Residency in Internal Medicine Howard University Hospital, Fellowship in Sickle Cell Disease
Languages:
English Spanish Bengali
Board certifications:
Gastroenterology (Internal Medicine)
Hospital affiliations:
Inova Alexandria Hospital Inova Fairfax Hospital
About:
Dr. Hoque takes pride in treating and educating his patients while providing excellent care. Dr. Hoque is board certified Gastroenterology and recently brought his practice from Colorado to the DC are...
Dr. Mohammad E Hoque, Washington DC - MD (Doctor of Medicine)
IU Health PhysiciansIndiana University Health Arnett Cardiovascular Services 1116 N 16 St STE A, Lafayette, IN 47904 (765)4488000 (phone), (765)4488807 (fax)
Education:
Medical School Dhaka Med Coll, Dhaka Univ, Bangladesh Graduated: 1998
Procedures:
Angioplasty Cardiac Catheterization Echocardiogram Electrocardiogram (EKG or ECG)
Dr. Hoque graduated from the Dhaka Med Coll, Dhaka Univ, Bangladesh in 1998. He works in Lafayette, IN and specializes in Cardiovascular Disease. Dr. Hoque is affiliated with Indiana University Health Arnett Hospital.