Mohammad Khalid Hossain

US Patent:

20110206699, Aug 25, 2011

Filed:

Oct 2, 2009

Appl. No.:

13/121016

Inventors:

Mohammad S. Hossain - Norcross GA, US
Andrew T. Gewitz - Smyrna GA, US
John D. Roback - Smyrna GA, US
Edmund K. Waller - Atlanta GA, US

Assignee:

EMORY UNIVERSITY - Atlanta GA

International Classification:

A61K 39/395
A61K 39/02
A61K 39/112
A61P 37/06

US Classification:

4241721, 4242341, 4242581

Abstract:

Methods are disclosed for treating or preventing graft versus host disease in a subject. The methods include selecting a subject in need of treatment for graft versus host disease; and administering to the subject a therapeutically effective amount of a TLR5 agonist such as a flagellin polypeptide, or a polynucleotide encoding the flagellin, thereby treating or preventing graft versus host disease in the subject. Methods are also disclosed for reducing susceptibility to an opportunistic infection in a subject who is a bone marrow transplant recipient. The methods include selecting a subject who has had a bone marrow or hematopoietic stem cell transplant; and administering to the subject a therapeutically effective amount of a TLR5 agonist such as a flagellin polypeptide or a polynucleotide encoding the polypeptide, and administering to the subject an effective amount antigen of the opportunistic infection, thereby reducing the susceptibility to the opportunistic infection in the subject.

US Patent:

20170258904, Sep 14, 2017

Filed:

May 22, 2017

Appl. No.:

15/601352

Inventors:

- Atlanta GA, US
Jian-Ming Li - Atlanta GA, US
Mohammad Hossain - Lilburn GA, US

International Classification:

A61K 39/395
A61K 38/22
A61K 35/14
A61K 38/04
A61K 39/245
A61K 38/16
A61K 35/17

Abstract:

Inhibition of the VIP signaling pathway with VIP antagonist is contemplated. In certain embodiments, the disclosure relates to methods of enhancing the immune response to a cell therapy comprising administering a VIP antagonist to a subject in combination with a cell. In certain embodiments, the subject is diagnosed with leukemia or lymphoma. In certain embodiments, the cell is a blood cell, bone marrow cell, leukocyte, T-cell, natural killer cell, a hematopoietic stem cell, a G-CSF mobilized or non-mobilized blood mononuclear cell.

US Patent:

20150343045, Dec 3, 2015

Filed:

May 28, 2015

Appl. No.:

14/724388

Inventors:

- Auburn AL, US
Jeffery S. Terhune - Auburn AL, US
Joseph C. Newton - Auburn AL, US
Mohammad J. Hossain - Auburn AL, US
Dawei Sun - Auburn AL, US
Charles Thurlow - Auburn AL, US

Assignee:

AUBURN UNIVERSITY - Auburn AL

International Classification:

A61K 39/02
C12N 15/74

Abstract:

Disclosed are attenuated bacteria, compositions comprising attenuated bacteria, and vectors and methods for preparing attenuated bacteria. The attenuated bacteria may include attenuated for use in vaccinating aquatic animals such as channel catfish against Motile Septicemia (MAS).