Nan Li

US Patent:

20120162438, Jun 28, 2012

Filed:

Sep 7, 2010

Appl. No.:

13/394261

Inventors:

Nitish Thakor - Clarksville MD, US
Abhishek Rege - Baltimore MD, US
Nan Li - Baltimore MD, US
Kartikeya Murari - Silver Spring MD, US

Assignee:

The John Hopkins University - Baltimore MD

International Classification:

H04N 7/18

US Classification:

348161, 348E07085

Abstract:

A system for multimodal laser speckle imaging may include a first light source positioned to emit laser light toward a target, a second light source positioned to emit light toward the target, a camera positioned to receive light scattered from the target, and a processor. The processor may be programmed to receive from the at least one camera at least one image of the target as illuminated by the laser, obtain a laser speckle contrast image of the target from the at least one image of the target as illuminated by the laser, receive from the at least one camera at least one image of the target as illuminated by the second light source, divide the laser speckle contrast image into subparts, and divide the at least one image of the target as illuminated by the second light source into identical subparts, determine whether each subpart includes a feature of a certain type by combining each subpart of the laser speckle contrast image with the at least one image of the target as illuminated by the second light source and comparing the combination with one or more criteria, and outputting the location and type of features detected in a subpart of the images.

US Patent:

20210371542, Dec 2, 2021

Filed:

Nov 7, 2018

Appl. No.:

16/762459

Inventors:

- Bethesda MD, US
Nan Li - Laurel MD, US
Dan Li - Bethesda MD, US

Assignee:

The U.S.A., as represented by the Secretary, Department of Health and Human Services - Bethesda MD

International Classification:

C07K 16/30
C07K 14/715
C07K 14/71
C07K 14/705
C07K 14/725
A61K 35/17
A61P 35/00

Abstract:

Nucleic acid constructs encoding a chimeric antigen receptor (CAR) and a truncated human epidermal growth factor receptor (huEGFRt) are described. The encoded CARs include a tumor antigen-specific monoclonal antibody, such as a glypican-3 (GPC3)-specific, a GPC2-specific or a mesothelin-specific monoclonal antibody, fused to a CD8α hinge region, a CD8α transmembrane region, a 4-1BB co-stimulatory domain and a CD3ζ signaling domain. Isolated host cells, such as isolated T cells that co-express the disclosed CARs and huEGFRt are also described. T cells transduced with the disclosed CAR constructs can be used for cancer immunotherapy.

US Patent:

20210292428, Sep 23, 2021

Filed:

Aug 6, 2019

Appl. No.:

17/266419

Inventors:

- Bethesda MD, US
Nan Li - Laurel MD, US
Bryan D. Fleming - Bethesda MD, US

Assignee:

The U.S.A., as represented by the Secretary, Department of Health and Human Services - Bethesda MD

International Classification:

C07K 16/30
C07K 14/725
A61K 47/68
G01N 33/574
C12N 15/86
A61P 35/00

Abstract:

Monoclonal antibodies that bind glypican-2 (GPC2) with high affinity are described. Immunotoxins and chimeric antigen receptors (CARs) that include the disclosed antibodies or antigen-binding fragments thereof are further described. In some instances, the antibody or antigen-binding fragment is humanized. The disclosed GPC2-specific antibodies and conjugates can be used, for example, for the diagnosis or treatment of GPC2-positive cancers, including neuroblastoma, medulloblastoma and retinoblastoma.

US Patent:

20210089075, Mar 25, 2021

Filed:

Sep 19, 2019

Appl. No.:

16/576743

Inventors:

- Boston MA, US
Rohan Vaswani - Nashua NH, US
Nan LI - Quincy MA, US
Boris Kalinichenko - Jamaica Plain MA, US
Anton Aboukhalil - Waltham MA, US

International Classification:

G06F 1/14
H03M 13/00
G06F 16/906
G06F 16/9535

Abstract:

The Tactic Tracking, Evaluation and Identification Engine Apparatuses, Methods and Systems (“TTEIE”) transforms subscription request, tick notification request inputs via TTEIE components into subscription response, identified tactic store request, user interface update notification outputs. A subscription request datastructure from a client is obtained. A set of tactic definition datastructures is retrieved. A tick notification comprising tick data for a tick associated with a target is obtained. A contact datastructure corresponding to each retrieved tactic definition datastructure is added to a tracking list of contact datastructures for the target. The tick data for the tick is appended for each contact datastructure in the tracking list. A contact datastructure's time series of ticks is evaluated with regard to the respective contact datastructure's corresponding time series of rules to classify the respective contact datastructure, for each contact datastructure in the tracking list. The client is notified regarding identified tactic contact datastructures.

US Patent:

20200216558, Jul 9, 2020

Filed:

Jul 20, 2017

Appl. No.:

16/322712

Inventors:

- Bethesda US, US
Nan Li - Laurel MD, US
Dimiter S. Dimitrov - Pittsburgh PA, US

Assignee:

The U.S.A., as represented by the Secretary, Department of Health and Human Services - Bethesda MD

International Classification:

C07K 16/30
C07K 16/28
C07K 7/08
A61K 47/69
A61K 47/64
A61P 35/00

Abstract:

A panel of human variable heavy (VH) single domain monoclonal antibodies specific for cell-surface glypican-2 (GPC2) are described. Methods for the diagnosis and treatment and GPC2-positive cancer are also described. Recombinant immunotoxins comprised of a GPC2-specific VH domain antibody and a clinically used form of exotoxin A (PE38) were generated and shown to inhibit GPC2-positive neuroblastoma tumor cell growth and inhibit neuroblastoma xenograft growth in nude mice, without significant toxicity. Chimeric antigen receptors comprising a GPC2-specific VH single domain antibody are also described. T cells expressing the GPC2-specific CARs potently killed GPC2-positive neuroblastoma cells in a dose-dependent manner.

US Patent:

20160113504, Apr 28, 2016

Filed:

Oct 9, 2015

Appl. No.:

14/879260

Inventors:

- Baltimore MD, US
Nitish THAKOR - Clarksville MD, US
Kartikeya MURARI - Calgary, CA
Nan Li - Arlington MA, US

International Classification:

A61B 5/00
A61B 5/026

Abstract:

A system for multimodal laser speckle imaging may include a first light source positioned to emit laser light toward a target, a second light source positioned to emit light toward the target, a camera positioned to receive light scattered from the target, and a processor. The processor may be programmed to receive from the at least one camera at least one image of the target as illuminated by the laser, obtain a laser speckle contrast image of the target from the at least one image of the target as illuminated by the laser, receive from the at least one camera at least one image of the target as illuminated by the second light source, divide the laser speckle contrast image into subparts, and divide the at least one image of the target as illuminated by the second light source into identical subparts, determine whether each subpart includes a feature of a certain type by combining each subpart of the laser speckle contrast image with the at least one image of the target as illuminated by the second light source and comparing the combination with one or more criteria, and out-putting the location and type of features detected in a subpart of the images.

US Patent:

20140358292, Dec 4, 2014

Filed:

Jun 4, 2013

Appl. No.:

13/909756

Inventors:

- ARMONK NY, US
MARISSA ANN WOOD - HURST TX, US
NAN LI - CEDAR PARK TX, US
CHARLES EDMOND WIESE - RALEIGH NC, US

International Classification:

G05D 23/19
F24F 11/00

US Classification:

700276

Abstract:

Controlling the temperature gradient in an enclosed auditorium with positioned people by initially generating, by thermal input, a level selected base temperature plane coextensive with the plane of the enclosed room. Each of the positioned people is enabled to dynamically input a request for a temperature change in the base temperature plane at a position corresponding to the position of the person in the room plane. All of the input requests of positioned people may then be correlated with the base temperature plane to convert the base temperature plane into a base temperature curvature coextensive with the plane of the enclosed room. The thermal input may then be varied responsive to the sensed temperature variations to maintain the base temperature curvature.

US Patent:

20140135997, May 15, 2014

Filed:

Nov 14, 2012

Appl. No.:

13/676545

Inventors:

- Armonk NY, US
Marissa Ann Wood - Hurst TX, US
Nan Li - Cedar Park TX, US
Charles Edmond Wiese - Raleigh NC, US

Assignee:

INTERNATIONAL BUSINESS MACHINES CORPORATION - Armonk NY

International Classification:

G05B 13/02

US Classification:

700278

Abstract:

Optimum temperature in a room is controlled by directly and dynamically sensing the body temperatures of one or more people in the room and storing a set of parameters to be correlated with the sensed body temperatures in determining a selected optimum room temperature. The sensed body temperatures are wirelessly transmitted to be correlated with the set of parameters wherein optimum room temperature is determined based on those parameters. In response to this correlation, a selected optimum room temperature may be provided by appropriate heating or cooling.