Nathan P Roth

US Patent:

47761512, Oct 11, 1988

Filed:

Aug 25, 1987

Appl. No.:

7/089633

Inventors:

Nathan Roth - San Francisco CA
Andrew Nelsen - Palo Alto CA

Assignee:

ALZA Corporation - Palo Alto CA

International Classification:

B65B 1504
B65B 4904
B65B 1108

US Classification:

53435

Abstract:

The package of the present invention comprises a sheath formed from a folded, relatively rigid strip having structure for receiving and releasably holding the ends of the fiber to be packaged. In a preferred embodiment, the fiber is between the two folded over parts of the strip with the ends of the fiber anchored in place in a pair of slits. The sheath is in a pouch formed by a pair of foil members on opposite sides of the sheath. When ready for use, the package is opened by peeling the foil members apart, thereby exposing the sheath and permitting access to the fiber carried by the sheath. An improved apparatus and method are provided to form the package. In the first instance, the sheath is prepared by first folding a strip of relatively rigid material, such as siliconized polyester, then moving the folded strip along a path of travel and feeding the fiber into the region between the parts of the strip as the strip moves. At a certain location along the path of the strip, the fiber is forced into each slit of the strip and the fiber becomes releasably attached to the strip. At another location, the strip is cut; thus, in this way, a plurality of sheaths with fiber lengths between the sides of the sheaths are formed and are immediately moved to a location where the foil members are applied to the opposite sides of the sheaths.

US Patent:

63330504, Dec 25, 2001

Filed:

Jan 19, 2001

Appl. No.:

9/764074

Inventors:

Patrick S.-L. Wong - Burlingame CA
Howard B. Rosen - Woodside CA
Nathan Roth - San Francisco CA
Phyllis I. Gardner - Stanford CA

Assignee:

Alza Corporation - Palo Alto CA

International Classification:

A61K 914
A61K 924

US Classification:

424473

Abstract:

The present invention is directed to an oral active agent delivery system and method for delivering discrete units of an active agent formulation to a patient. An active agent formulation chamber containing the active agent formulation and having a fluid passing active agent formulation retainer is placed at a first end into a fluid and at a second end into a patient's mouth. The active agent is delivered when the patient sips on the second end of the chamber.

US Patent:

62249088, May 1, 2001

Filed:

May 24, 2000

Appl. No.:

9/577041

Inventors:

Patrick S.-L. Wong - Burlingame CA
Vincent J. Ferrari - Foster City CA
Jeffrey W. Etter - Castro Valley CA
Miriam A. Martin - Los Altos CA
Nathan Roth - San Francisco CA
Christopher M. G. Ohms - San Mateo CA
Andrew I. Poutiatine - Menlo Park CA
James Horvath - San Jose CA

Assignee:

Alza Corporation - Mountain View CA

International Classification:

A61K 924

US Classification:

424473

Abstract:

Oral active agent delivery system having improved flow controllers. A hollow tubular member containing the active agent formulation and having a fluid passing controller is placed at one end into a fluid and at a second end into a patient's mouth. The active agent is delivered when the patient sips on the end of the chamber. The improved controllers prevent leakage of the active agent formulation.

US Patent:

49292331, May 29, 1990

Filed:

Aug 26, 1988

Appl. No.:

6/236974

Inventors:

Nathan Roth - San Francisco CA
Su I. Yum - Los Altos CA

Assignee:

ALZA Corporation - Palo Alto CA

International Classification:

A61M 500

US Classification:

604131

Abstract:

An improved imbibing agent dispenser having a snap-on closure which is highly reliable, is simple to assemble on one end of the agent dispenser, and can be made at minimum expense without requiring heat or an adhesive to bond the closure to the dispenser. The closure is held in place on the dispenser by a locking feature formed by a shoulder on the end of the dispenser and a ledge on an outer, annular wall of the closure, the ledge being removably hooked beneath and biased toward the shoulder to releasably lock the closure to the dispenser. An important aspect of this closure is that the design provides for the complete containment of a solute component within the dispenser.

US Patent:

59103213, Jun 8, 1999

Filed:

Oct 14, 1997

Appl. No.:

8/949753

Inventors:

Patrick S.-L. Wong - Burlingame CA
Nathan Roth - San Francisco CA
Vincent J. Ferrari - Foster City CA

Assignee:

Alza Corporation - Palo Alto CA

International Classification:

A61K 924

US Classification:

424473

Abstract:

The present invention is directed to an oral active agent delivery system and method for delivering discrete units of an active agent to a patient. An elongate tubular member having first and second ends comprises first and second flow paths. Either or both of said flow paths contains an active agent. Liquid is drawn up into the first end of the member, and the liquid and active agent is drawn out of the second end of the member and into the patient's mouth.

US Patent:

61032654, Aug 15, 2000

Filed:

Sep 22, 1999

Appl. No.:

9/401610

Inventors:

Patrick S.-L. Wong - Burlingame CA
Vincent J. Ferrari - Foster City CA
Jeffrey W. Etter - Castro Valley CA
Miriam A. Martin - Los Altos CA
Nathan Roth - San Francisco CA
Christopher M. G. Ohms - San Mateo CA
Andrew I. Poutiatine - Menlo Park CA
James Horvath - San Jose CA

Assignee:

ALZA Corporation - Mountain View CA

International Classification:

A61K 924

US Classification:

424473

Abstract:

The present invention is directed to an oral active agent delivery system comprising improved flow controllers. A hollow tubular member (10) containing the active agent formulation and having a fluid passing controller (14) is placed at one end (16) into a fluid and at a second end (18) into a patient's mouth. The active agent is delivered when the patient sips on the end of the chamber. The improved controllers prevent leakage of the active agent formulation.

US Patent:

49464566, Aug 7, 1990

Filed:

Aug 26, 1988

Appl. No.:

7/236868

Inventors:

Nathan Roth - San Francisco CA
Su I. Yum - Los Altos CA
Felix Theeuwes - Los Altos CA

Assignee:

Alza Corp. - Palo Alto CA

International Classification:

A61K 922

US Classification:

6048921

Abstract:

An agent dispenser of the fluid imbibing type having a flexible bag within a membrane and in which a wicking or wetting device is in contact with the outer surface of the membrane to keep such outer surface wet at all times for all attitudes of a containment vessel housing the bag and the membrane. The wicking device is in the form of a fabric tube, such as a stretch knit fabric, or a preformed hydrophilic polymeric sleeve, which can be mounted on the outer surface of the membrane and remain in contact with it so long as there is any liquid in the containment vessel. Since the amount of water drawn by the wicking device is controlled by the membrane porosity and the amount of a solute composition in an intermediate layer between the bag and the membrane, the wicking device provides for a continuous controlled delivery of agent from the inner bag of the dispenser.

US Patent:

62107135, Apr 3, 2001

Filed:

Feb 25, 2000

Appl. No.:

9/513074

Inventors:

Patrick S.-L. Wong - Burlingame CA
Howard B. Rosen - Woodside CA
Nathan Roth - San Francisco CA
Phyllis I. Gardner - Stanford CA

Assignee:

Alza Corporation - Palo Alto CA

International Classification:

A61K 914
A61K 924

US Classification:

424473

Abstract:

The present invention is an oral active agent delivery system and method for delivering discrete units of an active agent formulation to a patient. An active agent formulation chamber containing the active agent formulation and having a fluid passing active agent formulation retainer is placed at a first end into a fluid and at a second end into a patient's mouth. The active agent is delivered when the patient sips on the second end of the chamber.