Nicholas E Ashton

US Patent:

20210031016, Feb 4, 2021

Filed:

Aug 15, 2020

Appl. No.:

16/994577

Inventors:

- Salt Lake City UT, US
Nicholas Ashton - Holladay UT, US

International Classification:

A61M 39/02
A61M 31/00
A61M 39/10

Abstract:

A therapeutic delivery device that provides a controlled release of high doses of a therapeutic agent in a local area, sustains the high dose controlled release with a percutaneous port for refilling the device, and is versatile for use with multiple types of therapeutic agents and/or implant systems. A rate determining/controlled release membrane is used to decrease the molecular mobility of the therapeutic compounds thereby controlling the therapeutic release profile. The therapeutic delivery device includes a body defining an internal reservoir for receiving a therapeutic agent and including a first membrane for providing a controlled release of the therapeutic agent to the surgical site, a port in fluid communication with the reservoir, a sleeve configured to encapsulate the body, and a rigid housing configured to support the body and a portion of the sleeve, the rigid housing configured to release the body and the sleeve after the body and the sleeve are anchored position relative to the surgical site.

US Patent:

20210031017, Feb 4, 2021

Filed:

Aug 15, 2020

Appl. No.:

16/994578

Inventors:

- Salt Lake City UT, US
Nicholas Ashton - Holladay UT, US

International Classification:

A61M 39/02
A61M 31/00
A61M 39/10

Abstract:

A therapeutic delivery device that provides a controlled release of high doses of a therapeutic agent in a local area, sustains the high dose controlled release with a percutaneous port for refilling the device, and is versatile for use with multiple types of therapeutic agents and/or implant systems. A rate determining/controlled release membrane is used to decrease the molecular mobility of the therapeutic compounds thereby controlling the therapeutic release profile. The therapeutic delivery device includes a body defining an internal reservoir for receiving a therapeutic agent and including a first membrane for providing a controlled release of the therapeutic agent to the surgical site, a port in fluid communication with the reservoir, a sleeve configured to encapsulate the body, and a rigid housing configured to support the body and a portion of the sleeve, the rigid housing configured to release the body and the sleeve after the body and the sleeve are anchored position relative to the surgical site.

US Patent:

20210031018, Feb 4, 2021

Filed:

Aug 15, 2020

Appl. No.:

16/994584

Inventors:

- Salt Lake City UT, US
Nicholas Ashton - Holladay UT, US

International Classification:

A61M 39/02
A61M 31/00
A61M 39/10

Abstract:

Methods and devices for eradicating biofilms and planktonic bacteria are provided. In on embodiment, a therapeutic delivery device comprised of at least a port and a antimicrobial releasing pouch and one or more therapeutic agents is provided to the mammal. In one aspect of at least one embodiment the releasing pouch has an internal reservoir comprised of a membrane that is configured to contain the one or more therapeutic agents that is to be administered to the mammal and the port is in fluid communication with the pouch and configured such that the pouch can be refilled with one or more therapeutic agents via the port. In other aspect of at least one embodiment the method is able to fully eradicate 10colony forming units (CFU) of methicillin-resistant (MRSA) within a 24 hr period.

US Patent:

20200376250, Dec 3, 2020

Filed:

Aug 15, 2020

Appl. No.:

16/994575

Inventors:

- Salt Lake City UT, US
Nicholas Ashton - Holladay UT, US

International Classification:

A61M 39/02
A61M 31/00
A61M 39/10

Abstract:

A therapeutic delivery device that provides a controlled release of high doses of a therapeutic agent in a local area, sustains the high dose controlled release with a percutaneous port for refilling the device, and is versatile for use with multiple types of therapeutic agents and/or implant systems. A rate determining/controlled release membrane is used to decrease the molecular mobility of the therapeutic compounds thereby controlling the therapeutic release profile. The therapeutic delivery device includes a body defining an internal reservoir for receiving a therapeutic agent and including a first membrane for providing a controlled release of the therapeutic agent to the surgical site, a port in fluid communication with the reservoir, a sleeve configured to encapsulate the body, and a rigid housing configured to support the body and a portion of the sleeve, the rigid housing configured to release the body and the sleeve after the body and the sleeve are anchored position relative to the surgical site.

US Patent:

20200376251, Dec 3, 2020

Filed:

Aug 15, 2020

Appl. No.:

16/994581

Inventors:

- Salt Lake City UT, US
Nicholas Ashton - Holladay UT, US

International Classification:

A61M 39/02
A61M 31/00
A61M 39/10

Abstract:

A therapeutic delivery device that provides a controlled release of high doses of a therapeutic agent in a local area, sustains the high dose controlled release with a percutaneous port for refilling the device, and is versatile for use with multiple types of therapeutic agents and/or implant systems. A rate determining/controlled release membrane is used to decrease the molecular mobility of the therapeutic compounds thereby controlling the therapeutic release profile. The therapeutic delivery device includes a body defining an internal reservoir for receiving a therapeutic agent and including a first membrane for providing a controlled release of the therapeutic agent to the surgical site, a port in fluid communication with the reservoir, a sleeve configured to encapsulate the body, and a rigid housing configured to support the body and a portion of the sleeve, the rigid housing configured to release the body and the sleeve after the body and the sleeve are anchored position relative to the surgical site.

US Patent:

20190030311, Jan 31, 2019

Filed:

Jul 27, 2018

Appl. No.:

16/047917

Inventors:

- Salt Lake City UT, US
Nicholas Ashton - Holladay UT, US

International Classification:

A61M 39/02
A61M 39/10
A61M 31/00

Abstract:

A therapeutic delivery device that provides a controlled release of high doses of a therapeutic agent in a local area, sustains the high dose controlled release with a percutaneous port for refilling the device, and is versatile for use with multiple types of therapeutic agents and/or implant systems. A rate determining/controlled release membrane is used to decrease the molecular mobility of the therapeutic compounds thereby controlling the therapeutic release profile. The therapeutic delivery device includes a body defining an internal reservoir for receiving a therapeutic agent and including a first membrane for providing a controlled release of the therapeutic agent to the surgical site, a port in fluid communication with the reservoir, a sleeve configured to encapsulate the body, and a rigid housing configured to support the body and a portion of the sleeve, the rigid housing configured to release the body and the sleeve after the body and the sleeve are anchored position relative to the surgical site.