Patrick M Moore

US Patent:

6500663, Dec 31, 2002

Filed:

Mar 6, 2000

Appl. No.:

09/519489

Inventors:

Yuan Chang - New York NY
Patrick S. Moore - New York NY

Assignee:

The Trustees of Columbia University in the City of New York - New York NY

International Classification:

C12N 700

US Classification:

4352351, 435 71, 435325, 4353722, 4242291, 4242301, 536 2372

Abstract:

This invention provides an isolated DNA molecule which is at least 30 nucleotides in length and which uniquely defines a herpesvirus associated with Kaposis sarcoma. This invention provides an isolated herpesvirus associated with Kaposis sarcoma. This invention provides an isolated peptide encoded by the isolated DNA molecule. Further, this invention provides an isolated DNA virus wherein the viral DNA is about 270 kb in size; wherein the DNA encodes a thymidine kinase; and wherein the viral DNA is capable of selectively hybridizing to a nucleic acid probe selected from the group consisting of SEQ. ID NOs:10-12. This invention provides an antibody specific to the peptide. Antisense and triplex oligonucleotide molecules are also provided. This invention provides a transgenic nonhuman mammal and a cell line containing at least a portion of the isolated DNA molecule. This invention provides a method of vaccinating a subject for KS, prophylaxis diagnosing or treating a subject with KS and detecting expression of a DNA virus associated with Kaposis sarcoma in a cell.

US Patent:

7932066, Apr 26, 2011

Filed:

May 9, 2007

Appl. No.:

11/801641

Inventors:

Yuan Chang - New York NY, US
Patrick S. Moore - New York NY, US

Assignee:

The Trustees of Columbia University in the City of New York - New York NY

International Classification:

C12N 9/00
C07K 5/00

US Classification:

435174, 530300

Abstract:

This invention provides an isolated peptide encoded by a nucleic acid which is at least 30 nucleotides in length and has a sequence which uniquely defines a herpesvirus associated with Kaposis' sarcoma, which herpesvirus is present in and recoverable from the HBL-6 cell line (ATCC Accession No. CRL 11762).

US Patent:

20110265195, Oct 27, 2011

Filed:

Apr 26, 2011

Appl. No.:

13/094522

Inventors:

Yuan Chang - New York NY, US
Patrick S. Moore - New York NY, US

International Classification:

A01K 67/033
A61K 39/42
A61P 31/22
C07K 16/08
C07K 14/03
A61P 37/04
C07H 21/04
C12N 9/38

US Classification:

800 13, 536 245, 536 231, 4241591, 530395, 435207, 5303894, 5303883, 530350

Abstract:

This invention provides an isolated peptide encoded by a nucleic acid which is at least 30 nucleotides in length and has a sequence which uniquely defines a herpesvirus associated with Kaposis' sarcoma, which herpesvirus is present in and recoverable from the HBL-6 cell line (ATCC Accession No. CRL 11762).

US Patent:

59486767, Sep 7, 1999

Filed:

Oct 10, 1996

Appl. No.:

8/728323

Inventors:

Yuan Chang - New York NY
Roy A. Bohenzky - Mountain View CA
James J. Russo - New York NY
Isidore S. Edelman - New York NY
Patrick S. Moore - New York NY

Assignee:

The Trustees of Columbia University in the City of New York - New York NY

International Classification:

C12N 1500
C12N 1509

US Classification:

435325

Abstract:

This invention provides an isolated nucleic acid molecule which encodes Kaposi's Sarcoma-Associated Herpesvirus (KSHV) immediate early protein (IEP). This invention provides an isolated polypeptide molecule which encodes KSHV immediate early protein. This invention provides an antibody specific to the polypeptide. Antisense and triplex oligonucleotide molecules are also provided. This invention provides a vaccine for Kaposi's Sarcoma (KS). This invention provides methods of vaccination, prophylaxis, diagnosis and treatment of a subject with KS and of detecting expression of a DNA virus associated with Kaposi's sarcoma in a cell.

US Patent:

58544186, Dec 29, 1998

Filed:

Jul 25, 1996

Appl. No.:

8/687253

Inventors:

Yuan Chang - New York NY
Roy A. Bohenzky - Mountain View CA
James J. Russo - New York NY
Isidore S. Edelman - New York NY
Patrick S. Moore - New York NY

Assignee:

The Trustees of Columbia University in the City of New York - New York NY

International Classification:

A61K 39245
C07H 2104
C07K 1403
C12N 1538

US Classification:

536 2372

Abstract:

This invention provides an isolated DNA molecule which encodes viral macrophage inflammatory protein-1. alpha. II (vMIP-1. alpha. II). Antisense and oligonucleotide molecules are also provided.

US Patent:

58615008, Jan 19, 1999

Filed:

Jul 25, 1996

Appl. No.:

8/686349

Inventors:

Yuan Chang - New York NY
Roy A. Bohenzky - Mountain View CA
James J. Russo - New York NY
Isidore S. Edelman - New York NY
Patrick S. Moore - New York NY

Assignee:

The Trustees of Columbia University in the City of New York - New York NY

International Classification:

A61K 39245
C07H 2104
C07K 1403
C12N 1538

US Classification:

536 2372

Abstract:

This invention provides an isolated DNA molecule which encodes interleukin 6 (IL-6) of Kaposi's sarcoma-associated herpesvirus. Antisense oligonucleotide molecules are also provided.

US Patent:

54512182, Sep 19, 1995

Filed:

Mar 2, 1994

Appl. No.:

8/204739

Inventors:

Patrick S. Moore - New York NY

International Classification:

A61M 100

US Classification:

604317

Abstract:

The invention relates to an improved urinary drainage device which simulates the inlet end of the normal, non-catheterized urethra. This novel design significantly reduces the risk of urinary tract infection typically associated with internal catheters by providing a drainage duct comprising a truncated, collapsible inner lumen. Like the non-catheterized urethra, the collapsible inner lumen collapses after urination to prevent urine back flow. The invention further relates to an improved evacuator-type collection receptacle, the improvement comprising a resilient means or displacement means for controlling the negative pressure created within the collection receptacle.

US Patent:

60935502, Jul 25, 2000

Filed:

Oct 30, 1998

Appl. No.:

9/183688

Inventors:

Yuan Chang - New York NY
Patrick S. Moore - New York NY

Assignee:

The Trustees of Columbia University in the City of New York - New York NY

International Classification:

G01N 3353
C12N 500
A61K 39245
C07H 2104

US Classification:

435 71

Abstract:

This invention provides an isolated DNA molecule which is at least 30 nucleotides in length and which uniquely defines a herpesvirus associated with Kaposi's sarcoma. This invention provides an isolated herpesvirus associated with Kaposi's sarcoma. This invention provides an isolated peptide encoded by the isolated DNA molecule. Further, this invention provides an isolated DNA virus wherein the viral DNA is about 270 kb in size; wherein the DNA encodes a thymidine kinase; and wherein the viral DNA is capable of selectively hybridizing to a nucleic acid probe selected from the group consisting of SEQ. ID NOs: 10-12. This invention provides an antibody specific to the peptide. Antisense and triplex oligonucleotide molecules are also provided. This invention provides a transgenic nonhuman mammal and a cell line containing at least a portion of the isolated DNA molecule. This invention provides a method of vaccinating a subject for KS, prophylaxis diagnosing or treating a subject with KS and detecting expression of a DNA virus associated with Kaposi's sarcoma in a cell.