Paul R Darkes

US Patent:

51623366, Nov 10, 1992

Filed:

Aug 24, 1990

Appl. No.:

7/573514

Inventors:

Bruce F. Molino - Hatfield PA
Paul R. Darkes - Lansdale PA
William R. Ewing - King of Prussia PA

Assignee:

Rhone-Poulenc Rorer Pharmaceuticals Inc. - Collegeville PA

International Classification:

C07D47104
A61K 3144

US Classification:

514292

Abstract:

Disclosed are tetrahydro-pyrido-indoles having the general formula ##STR1## which are antagonists towards the neuropeptides cholexystokinin and gastrin processing valuable activities for the treatment of cholecystokinin or gastrin-related disorders of the gastrointestinal, central nervous and appetite regulatory systems and their pharmaceutical compositions and processes for their preparation.

US Patent:

42673887, May 12, 1981

Filed:

Jul 12, 1979

Appl. No.:

6/056984

Inventors:

Paul R. Darkes - Norristown PA
Henry F. Campbell - Lansdale PA
George H. Douglas - Malvern PA

Assignee:

William H. Rorer, Inc. - Fort Washington PA

International Classification:

C07C 4118
C07C 4124
C07C 2518
C07C 2524

US Classification:

568642

Abstract:

There is disclosed a novel process for preparing anti-inflammatory ethynylbenzene derivatives represented by the general formula I: ##STR1## wherein Y is hydrogen, halogen or loweralkyl of 1 to 3 carbon atoms; R represents a ring having the structure: ##STR2## wherein x is 1 to 3, or a ring of the structure: ##STR3## wherein Y' is hydrogen, halogen, loweralkyl of 1 to 3 carbon atoms and loweralkoxy of 1 to 3 carbon atoms; Y" is hydrogen or halogen; and Y"' is hydrogen or halogen, provided Y, Y', Y" and Y"' are not all hydrogen at the same time, by reacting a benzyl alcohol of formula V: ##STR4## with a sulfonyl chloride, reducing the sulfonate VI of the formula: ##STR5## and dehydrohalogenating the formed. beta. -halostyrene of the formula VII: ##STR6##.