Peter Andrew Howley

US Patent:

6399075, Jun 4, 2002

Filed:

Jul 2, 1999

Appl. No.:

09/347504

Inventors:

Peter M. Howley - Wellesley MA
John Benson - Brookline MA
Hiroaki Kasukawa - Princeton NJ

Assignee:

President and Fellows of Harvard College - Cambridge MA

International Classification:

A61K 3912

US Classification:

4242041, 514 12, 530350, 530321, 530325, 530326, 5303884, 536 2374

Abstract:

By virtue of the present invention, there is provided methods and compositions for interfering with the proliferation of cells infected and/or transformed by papillomaviruses. The processes and compositions of this invention may be used to treat any mammal, including humans. According to this invention, mammals are treated by the pharmaceutically acceptable administration of an E2 peptidomimetic to reduce the symptoms of the specific papillomavirus-associated disease, or to prevent their recurrence.

US Patent:

6432926, Aug 13, 2002

Filed:

Jul 27, 1999

Appl. No.:

09/362012

Inventors:

Peter M. Howley - Wellesley MA
John D. Benson - Brookline MA
Hiroyuki Sakai - Kyoto, JP

Assignee:

President and Fellows of Harvard College - Cambridge MA

International Classification:

A61K 4800

US Classification:

514 44, 514 12, 536 231, 435325, 435455, 4242041

Abstract:

By virtue of the present invention, there is provided methods and compositions for interfering with the proliferation of cells infected and/or transformed by papillomaviruses. The processes and compositions of this invention may be used to treat any mammal, including humans. According to this invention, mammals are treated by the pharmaceutically acceptable administration of an E2 protein, either directly or by gene transfer techniques, to reduce the symptoms of the specific papillomavirus-associated disease, or to prevent their recurrence.

US Patent:

6673354, Jan 6, 2004

Filed:

Jun 3, 2002

Appl. No.:

10/161499

Inventors:

Peter M. Howley - Wellesley MA
John Benson - Brookline MA
Hiroaki Kasukawa - Princeton NJ

Assignee:

President and Fellows of Harvard College - Cambridge MA

International Classification:

A61K 3912

US Classification:

4242041, 514 12, 530350, 530321, 530325, 530326, 5303884, 536 2374

Abstract:

By virtue of the present invention, there is provided methods and compositions for interfering with the proliferation of cells infected and/or transformed by papillomaviruses. The processes and compositions of this invention may be used to treat any mammal, including humans. According to this invention, mammals are treated by the pharmaceutically acceptable administration of an E2 peptidomimetic to reduce the symptoms of the specific papillomavirus-associated disease, or to prevent their recurrence.

US Patent:

7235244, Jun 26, 2007

Filed:

Dec 23, 2003

Appl. No.:

10/744964

Inventors:

Peter M. Howley - Wellesley MA, US
John Benson - Brookline MA, US
Hiroaki Kasukawa - Princeton NJ, US

Assignee:

President and Fellows of Harvard College - Cambridge MA

International Classification:

A61K 39/12

US Classification:

4242041, 530300, 435 691

Abstract:

By virtue of the present invention, there is provided methods and compositions for interfering with the proliferation of cells infected and/or transformed by papillomaviruses. The processes and compositions of this invention may be used to treat any mammal, including humans. According to this invention, mammals are treated by the pharmaceutically acceptable administration of an E2 peptidomimetic to reduce the symptoms of the specific papillomavirus-associated disease, or to prevent their recurrence.

US Patent:

7423138, Sep 9, 2008

Filed:

Jul 1, 2002

Appl. No.:

10/187536

Inventors:

Peter M. Howley - Wellesley MA, US
John D. Benson - Brookline MA, US
Hiroyuki Sakai - Kyoto, JP

Assignee:

President and Fellows of Harvard College - Cambridge MA

International Classification:

A61K 39/12

US Classification:

536 2372, 4242041

Abstract:

By virtue of the present invention, there is provided methods and compositions for interfering with the proliferation of cells infected and/or transformed by papillomaviruses. The processes and compositions of this invention may be used to treat any mammal, including humans. According to this invention, mammals are treated by the pharmaceutically acceptable administration of an E2protein, either directly or by gene transfer techniques, to reduce the symptoms of the specific papillomavirus-associated disease, or to prevent their recurrence.

US Patent:

20060223055, Oct 5, 2006

Filed:

Dec 29, 2005

Appl. No.:

11/322164

Inventors:

Peter Howley - Wellesley MA, US
Jianxin You - Brookline MA, US

International Classification:

C12Q 1/70
C07H 21/04
C07K 14/03
C07K 16/08
C12N 15/86

US Classification:

435005000, 435069300, 435325000, 435456000, 530350000, 530388300, 536023720

Abstract:

The present invention relates to methods and compositions for the treatment and/or prevention of diseases or disorders associated with viral infection. Accordingly, the nucleotide and amino acid sequences for a human Brd4 protein are provided. Also provided are complexes comprising Brd4 and an E2 protein or a functional equivalent of an E2 protein.

US Patent:

55323480, Jul 2, 1996

Filed:

Jul 30, 1993

Appl. No.:

8/100692

Inventors:

Jon M. Huibregtse - Brighton MA
Martin Scheffner - Walldorf, DE
Peter M. Howley - Wellesley MA

Assignee:

United States of America - Washington DC

International Classification:

C07H 2104

US Classification:

536 235

Abstract:

The present invention provides compositions of isolated and purified E6 Associated Protein and fragments thereof. Also provided are nucleic acid constructs encoding E6 Associated Protein. These compositions may be employed to identify compounds which inhibit binding of high risk HPV E6 to p53. The compositions of the present invention may also be used in methods to detect the presence of high risk HPV in biological samples.

US Patent:

58210482, Oct 13, 1998

Filed:

Jun 7, 1995

Appl. No.:

8/472666

Inventors:

Peter M. Howley - Wellesley MA
John D. Benson - Brookline MA
Toshiharu Yasugi - Brookline MA
Hiroyuki Sakai - Brookline MA

Assignee:

President and Fellows of Harvard College - Cambridge MA

International Classification:

C12Q 170
C12Q 168
A01N 3718
C07K 100

US Classification:

435 5

Abstract:

Methods, kits, and compositions are provided for diagnosing papillomavirus infections by detecting the interaction between a papillomavirus E1 protein interaction domain and a papillomavirus E2 protein interaction domain.