Hui Zheng - Edison NJ Ping Jiang - Trenton NJ Su Qian - Sayreville NJ Leonardus H. T. Van Der Ploeg - Scotch Plains NJ Philip Chun-Ying Wong - Timonium MD Sangram S. Sisodia - Chicago IL
Assignee:
Merck Co., Inc. - Rahway NJ Johns Hopkins University - Baltimore NJ
International Classification:
A01K 6700
US Classification:
800 12, 3 18, 3 22, 3 25, 435 29, 435354
Abstract:
The present invention relates to a transgenic non-human animal embryo lacking native presenilin 1 and a transgenic non-human animal having only a non-native presenilin 1. The transgenic animals and cells derived therefrom can be used in the study of the expression pattern, activity and modulators of presenilin 1, in the study of the role of presenilin 1 in Alzheimers Disease and in the study of disorders of the central nervous system.