Qing Cheng Wang

US Patent:

20050112786, May 26, 2005

Filed:

Nov 25, 2003

Appl. No.:

10/723923

Inventors:

Qing Wang - Hollis Hills NY, US
Daniel Levine - Briarcliff Manor NY, US
Thomas Parker - Brooklyn NY, US

International Classification:

G01N033/553

US Classification:

436526000

Abstract:

Methods are described for attaching molecules to a solid phase, such as a magnetic bead. Free amine groups on the solid surface react with a molecule that contains a sulfhydryl group. The sulfhydryl group may, but need not be protected. The molecule is then reacted with a conjugate of linker and ligand. The liner has a reactive maleimide or sulfhydryl group which reacts with the molecule on the solid phase.

US Patent:

20130266032, Oct 10, 2013

Filed:

Apr 5, 2013

Appl. No.:

13/857810

Inventors:

Bing XU - Bayside NY, US
Qing Wang - Plainsboro NJ, US
Chuni Ghosh - West Windsor NJ, US

Assignee:

RealD Inc. - Beverly Hills CA

International Classification:

H01S 5/42
H01S 5/06

US Classification:

372 22

Abstract:

Disclosed herein are architectures for an external cavity laser. In some embodiments, the external cavity laser includes vertical cavity surface emitting laser (VCSEL) elements, a Brewster plate, frequency doubling chips, and a microlens array. The Brewster plate is arranged at an angle relative to the light path, and is configured to polarize at least the light received from the VCSELs and propagating on the light path in a first direction, and extract, from the external cavity, frequency-doubled light propagating on the light path in a second direction opposite to the first direction. The doubling chips are operable to receive the light and double the frequency of a portion of the received light. The microlens array is aligned with the VCSEL elements. A mount may be employed to mount the side stack of doubling chips by either side mounting or end mounting.

US Patent:

20210389280, Dec 16, 2021

Filed:

Jun 13, 2021

Appl. No.:

17/346282

Inventors:

- Baltimore MD, US
Qing WANG - Owings Mills MD, US

Assignee:

Complete Omics Inc. - Baltimore MD

International Classification:

G01N 30/06
G01N 30/88
G01N 30/72
G01N 1/34
G01N 33/68
G01N 1/28
G01N 1/40

Abstract:

A method for characterizing a target peptide through a detection approach such as mass spectrometry is provided, including: introducing at least one guard molecule to mix with the target peptide; and applying the detection approach for the characterization of the target peptide. Each guard molecule is configured to have similar characteristics as the target peptide, yet is still distinguishable therefrom by the detection approach, such as having a mass spectrometry-distinguishable different M/z value compared with the target peptide. The method can be used to characterize a neoantigen peptide through mass spectrometry, upstream of which the method can further include steps for tissue sample preparation, HLA molecules enrichment, elution, clean-up, and purification. Some or all of these steps can be configured to be executed in a substantially automatic manner with little or no manual intervention. A system for implementing the neoantigen analysis method is further provided.

US Patent:

20210373861, Dec 2, 2021

Filed:

May 26, 2020

Appl. No.:

16/882811

Inventors:

- Armonk NY, US
Jinho HWANG - Ossining NY, US
Qing Wang - Chappaqua NY, US
Larisa Shwartz - Greenwich CT, US
Michael Elton Nidd - Zurich, CH
Frank Bagehorn - Dottikon, CH
Jakub Krchák - Jindrichuv Hradec, CZ
Altynbek Orumbayev - Prague, CZ
Michal Mýlek - Vrane nad Vitavou, CZ
Ota Sandr - Praha, CZ
Tomás Ondrej - Prague, CZ

International Classification:

G06F 8/41
G06F 16/245
G06F 8/75

Abstract:

A computer implemented method for identifying an application topology includes identifying a sandbox environment corresponding to an application of interest, analyzing the sandbox environment to identify a set of communication links between services within the sandbox environment indicating a first topology, identifying a production system corresponding to the application of interest, querying the production system to identify a set of structural dependencies indicating a second topology, and creating a complete topology of the cloud application by combining the first topology and the second topology. A computer program product and computer system for identifying an application topology are additionally disclosed herein.

US Patent:

20210115435, Apr 22, 2021

Filed:

Dec 23, 2020

Appl. No.:

17/132121

Inventors:

Qing WANG - Owings Mills MD, US

International Classification:

C12N 15/10

Abstract:

A method and kit for constructing a barcoded single-stranded DNA library are disclosed. The method includes preparing single-stranded DNA molecules each having a dephosphorylated 5′ end, ligating a first adaptor to a 3′ end of each single-stranded DNA molecule, and synthesizing a complementary strand of each single-stranded DNA molecule ligated to the first strand of the first adaptor. The kit includes the first adaptor having a first strand, which includes, from a 5′ end to a 3′ end, a phosphate group, a barcode sequence, and a first primer recognition sequence. The kit also includes a DNA ligase for a ligation between the 5′ end of the first strand of the first adaptor to each single-stranded DNA molecule, and a first primer for the synthesis of the complementary strand. The method allows for analysis of rare mutations and from nucleic acid samples of low quality and quantity.

US Patent:

20210115503, Apr 22, 2021

Filed:

Dec 23, 2020

Appl. No.:

17/132099

Inventors:

Qing WANG - Owings Mills MD, US

International Classification:

C12Q 1/6837
C12Q 1/6876
C12Q 1/6818

Abstract:

A method and a kit for enriching target nucleic acid sequences from a biological sample are disclosed. The method includes preparing, and contacting with the biological sample, a first RNA probe set and a second RNA probe set respectively and concurrently targeting both of the two antiparallel strands of a duplex segment in each target nucleic acid sequence. Each RNA probe in the first and second RNA probe set can be generated by chemical synthesis or by in vitro or in vivo transcription, and can be biotin-labelled to thereby allow capturing of the target nucleic acid sequences by magnetic beads labelled with streptavidin, or can be engineered to a microfluidic channel to facilitate the capturing. The method can be applied to capture double-stranded nucleic acid sequences or single-stranded nucleic acid sequences having duplex segments, and the nucleic acid sequences can include DNAs, RNAs, or DNA-RNA hybrid molecules.

US Patent:

20210084059, Mar 18, 2021

Filed:

Sep 14, 2019

Appl. No.:

16/571088

Inventors:

- Armonk NY, US
Larisa Shwartz - Greenwich CT, US
Rohit Madhukar Khandekar - Jersey City NJ, US
Qing Wang - Ossining NY, US
Bing Zhou - Port Jefferson Station NY, US

International Classification:

H04L 29/06
G06N 3/08
G06F 16/901
H04L 12/26

Abstract:

A computer system, non-transitory computer storage medium, and a computer-implemented method of assessing technical risk using visual pattern recognition in an Information Technology (IT) Service Management System. A data visualization engine and a time series generation engine receive the operational data, respectively. A first representation of the data is generated by the data visualization engine, and a second representation of the data is generated by the time series generation engine. Anomaly patterns are identified by a pattern recognition engine configured to perform feature extraction and data transformation. An ensembler is configured to accept the outputs from two AI anomaly engines and make a final decision of whether anomaly patterns are captured. Risk scores based on the identified anomaly patterns are output by a pattern recognition engine to an automated management system. The anomalies includes information regarding vulnerabilities of devices or components of the IT Service Management System.

US Patent:

20200079854, Mar 12, 2020

Filed:

May 16, 2018

Appl. No.:

16/614005

Inventors:

- Baltimore MD, US
Qing Wang - Owings Mills MD, US
Bert Vogelstein - Baltimore MD, US
Kenneth W. Kinzler - Baltimore MD, US
Shibin Zhou - Owings Mills MD, US
Jacqueline Douglass - Baltimore MD, US
Michael S. Hwang - Seattle WA, US
Nickolas Papadopoulos - Towson MD, US

International Classification:

C07K 16/28
A61K 35/17
C07K 14/73
C07K 14/705
C07K 14/725

Abstract:

This document provides methods and materials for assessing a mammal having or suspected of having cancer and/or for treating a mammal having cancer. For example, molecules including one or more antigen-binding domains (e.g., a single-chain variable fragment (scFv)) that can bind to a modified peptide (e.g., a tumor antigen), as well as method for using such molecules, are provided.