Rajan R Gupta

US Patent:

20080026050, Jan 31, 2008

Filed:

Jun 29, 2007

Appl. No.:

11/771571

Inventors:

Rajan Gupta - Bridgewater NJ, US
Surendra Sangekar - Union NJ, US

International Classification:

A61K 9/48
A61K 31/44
A61P 9/00
A61K 31/535

US Classification:

424451000, 514235200, 514337000

Abstract:

Capsule formulations of a thrombin receptor antagonist for oral administration are disclosed. In some embodiments, the thrombin receptor antagonist is COMPOUND 1: or a pharmaceutically acceptable isomer, salt, or solvate thereof. The formulations include at least one excipient, such as a diluent, disintegrant and/or lubricant. Also disclosed are methods of treating acute coronary syndrome and peripheral arterial disease, and of effecting secondary prevention, by orally administering such capsule formulations.

US Patent:

20080031943, Feb 7, 2008

Filed:

Jun 29, 2007

Appl. No.:

11/771520

Inventors:

Rajan Gupta - Bridgewater NJ, US
Suliman Chawdry - South Plainfield NJ, US
Srinivas Duggirala - Raritan NJ, US

International Classification:

A61K 31/4433
A61K 9/20

US Classification:

424464000, 514337000

Abstract:

Immediate-release formulations for oral administration of a thrombin receptor antagonist are provided. Certain formulations of higher API loading demonstrate sufficient moisture uptake after storage at stressed conditions to retard dissolution. The formulations of the present invention incorporate either lower API loading or elevated disintegrant-to-API ratios, found necessary to achieve disintegration rates required for immediate-release performance.