Richard H Childs

US Patent:

20210128305, May 6, 2021

Filed:

Nov 5, 2020

Appl. No.:

17/090167

Inventors:

- Santa Clara CA, US
Alexander C. Chu - Diamond Bar CA, US
Richard Childs - San Francisco CA, US
Dylan Van Hoven - San Carlos CA, US
Gabriel Gonzales - Milpitas CA, US

Assignee:

EVALVE, INC. - Santa Clara CA

International Classification:

A61F 2/24

Abstract:

Stabilizer for a medical delivery system is provided, wherein the medical delivery system has at least two portions translatable relative each other. The stabilizer includes a base and a sled coupled to the base. The sled includes a distal arm including a distal attachment for receiving a first portion of the medical delivery system, and a proximal arm including a proximal attachment for receiving a second portion of the medical delivery system. The sled is translatable relative to the base and the proximal attachment is translatable relative to the proximal arm.

US Patent:

20180057795, Mar 1, 2018

Filed:

Nov 1, 2017

Appl. No.:

15/801085

Inventors:

Richard W. Childs - Rockville MD, US
David S.J. Allan - Rockville MD, US

International Classification:

C12N 5/0783
C12N 5/00
C12N 15/867

Abstract:

Disclosed herein are method of producing NK cells that include one or more heterologous nucleic acids. The methods include culturing a population of isolated NK cells in the presence of one or more cytokines to produce a population of activated NK cells. The population of activated NK cells are transduced with a viral vector comprising the one or more heterologous nucleic acids, for example by contacting the activated NK cells with viral particles including the viral vector. The resulting transduced NK cells are then cultured in the presence of one or more cytokines, and optionally in the presence of irradiated feeder cells, to produce a population of expanded transduced NK cells. Also disclosed are methods of treating a subject with a disorder (such as a tumor or hyperproliferative disorder) by administering to the subject NK cells produced by the methods described herein.