Richard H Connors

US Patent:

20110319378, Dec 29, 2011

Filed:

Jun 3, 2011

Appl. No.:

13/153345

Inventors:

Michael David BARTBERGER - Sherman Oaks CA, US
Ana GONZALEZ BUENROSTRO - San Mateo CA, US
Hilary Plake BECK - San Carlos CA, US
Xiaoqi CHEN - Palo Alto CA, US
Richard Victor CONNORS - Pacifica CA, US
Jeffrey DEIGNAN - San Francisco CA, US
Jason DUQUETTE - Millbrae CA, US
John EKSTEROWICZ - San Francisco CA, US
Benjamin FISHER - San Mateo CA, US
Brian Matthew FOX - Brisbane CA, US
Jiasheng FU - Foster City CA, US
Zice FU - Foster City CA, US
Felix GONZALEZ LOPEZ DE TURISO - San Mateo CA, US
Michael GRIBBLE, JR. - San Francisco CA, US
Darin James GUSTIN - Half Moon Bay CA, US
Julie Anne HEATH - Orinda CA, US
Xin HUANG - Wellesley MA, US
Xianyun JIAO - Belmont WA, US
Michael G. JOHNSON - San Francisco CA, US
Frank KAYSER - San Francisco CA, US
David John KOPECKY - San Francisco CA, US
Sujen LAI - Burlingame CA, US
Yihong LI - Millbrae CA, US
Zhihong LI - Millbrae CA, US
Jiwen LIU - Foster City CA, US
Jonathan Dante LOW - Tarzana CA, US
Brian Stuart LUCAS - San Francisco CA, US
Zhihua MA - Foster City CA, US
Lawrence McGEE - Pacifica CA, US
Joel McINTOSH - Pacifica CA, US
Dustin McMINN - Pacifica CA, US
Julio Cesar MEDINA - San Carlos CA, US
Jeffrey Thomas MIHALIC - San Francisco CA, US
Steven Howard Olson - Foster City CA, US
Yosup REW - Foster City CA, US
Philip Marley ROVETO - San Francisco CA, US
Daqing SUN - Foster City CA, US
Xiaodong WANG - Millbrae CA, US
Yingcai WANG - Millbrae CA, US
Xuelei YAN - Foster City CA, US
Ming YU - Foster City CA, US
Jiang ZHU - Palo Alto CA, US

Assignee:

AMGEN INC. - Thousand Oaks CA

International Classification:

A61K 31/451
C07D 413/06
A61K 31/5377
C07D 401/06
A61K 31/454
C07D 417/06
A61K 31/541
A61K 31/4545
C07D 413/12
C07D 471/10
A61K 31/438
C07D 409/04
A61K 31/4535
A61K 31/496
C07D 279/02
C07D 498/08
A61K 31/5386
A61K 31/549
C07D 498/16
A61K 31/437
A61P 35/00
C07D 211/40

US Classification:

5142102, 546221, 514327, 544130, 5142355, 546208, 514326, 544 582, 5142278, 546209, 546194, 514318, 546216, 5142372, 546 17, 514278, 546213, 544360, 51425312, 544 3, 5142222, 544105, 5142305, 544 11, 5142228, 546 90, 514291

Abstract:

The present invention provides MDM2 inhibitor compounds of Formula I,

US Patent:

20190275008, Sep 12, 2019

Filed:

Nov 3, 2017

Appl. No.:

16/347903

Inventors:

- Thousand Oaks CA, US
Ning CHEN - Thousand Oaks CA, US
Xiaoqi CHEN - Palo Alto CA, US
Yinhong CHEN - Hayward CA, US
Alan C. CHENG - San Francisco CA, US
Richard V. CONNORS - Mesa AZ, US
Jeffrey DEIGNAN - San Francisco CA, US
Paul John DRANSFIELD - Arlington MA, US
Xiaohui DU - Belmont CA, US
Zice FU - Foster City CA, US
James S. HARVEY - Arlington MA, US
Julie Anne HEATH - Chico CA, US
Lars V. HEUMANN - Redwood City CA, US
Jonathan HOUZE - Cambridge MA, US
Frank KAYSER - San Francisco CA, US
Aarif Yusuf KHAKOO - Woodside CA, US
David j. KOPECKY - Washington D.C. DC, US
Su-Jen LAI - Cambridge MA, US
Zhihua MA - Lexington MA, US
Julio C. MEDINA - San Carlos CA, US
Jeffrey T. MIHALIC - San Francisco CA, US
Steven H. OLSON - Millbrae CA, US
Vatee PATTAROPONG - Bedford MA, US
Gayathri SWAMINATH - Brisbane CA, US
Xiaodong WANG - Johns Creek GA, US
Malgorzata WANSKA - Camarillo CA, US
Wen-Chen YEH - Belmont CA, US

Assignee:

AMGEN INC. - Thousand Oaks CA

International Classification:

A61K 31/4196
C07D 405/14
C07D 405/04
A61K 31/506
C07D 405/12
C07D 471/04
A61K 31/437
C07F 7/08
A61K 31/4439
A61K 31/501
C07D 413/12
A61K 31/421
C07D 239/26
C07D 403/12

Abstract:

Compounds of Formula (I) and Formula (II), pharmaceutically acceptable salt thereof, stereoisomers of any of the foregoing, or mixtures thereof are agonists of the APJ Receptor and have use in treating cardiovascular and other conditions. Compounds of Formula (I) and Formula (II) have the following structures: (I); (II). Intermediates (V) are also claimed.