Robert E Applegate

US Patent:

8119976, Feb 21, 2012

Filed:

Jul 2, 2008

Appl. No.:

12/167136

Inventors:

Jeff Squier - Golden CO, US
David W. M. Marr - Golden CO, US
Robert Applegate - Golden CO, US
Tor Vestad - Golden CO, US
Justin Chichester - Centennial CO, US

Assignee:

Colorado School of Mines - Golden CO

International Classification:

H01S 1/00

US Classification:

250251, 4351739

Abstract:

A system, method, and device for re-orienting and/or deforming cells and other objects is provided. The system, method, and device may include a high-throughput setup that facilitates the ability to orient, deform, analyze, measure, and/or tag objects at a substantially higher rate than was previously possible. A relatively large number of cells and other objects can be deformed, by optical forces for example, as the cells and other objects a flowed through the system.

US Patent:

20090110010, Apr 30, 2009

Filed:

Sep 26, 2008

Appl. No.:

12/239449

Inventors:

Jeff Squier - Golden CO, US
David W.M. Marr - Golden CO, US
Robert Applegate - Golden CO, US
Tor Vestad - Golden CO, US

Assignee:

COLORADO SCHOOL OF MINES - Golden CO

International Classification:

H01S 3/10

US Classification:

372 9

Abstract:

The direct integration of light and optical control into microfluidic systems presents a significant hurdle to the development of portable optical trapping-based devices. A simple, inexpensive fiber-based approach is provided that allows for easy implementation of diode-bars for optical particle separations within flowing microfluidic systems. Models have also been developed that demonstrate the advantages of manipulating particles within flow using linear geometries as opposed to individually focused point traps as traditionally employed in optical-trapping micromanipulation.