An improved voltage reference circuit relies on electrically adjustable analog devices fabricated on a common substrate. The circuit has two electrically adjustable matched transistor pairs. A first matched transistor pair includes an adjusting transistor and a differential pair transistor. A second matched transistor pair also includes an adjusting transistor and a differential pair transistor. Each of the matched transistor pairs share an insulated gate or electrically connected insulated gates. Geometrical and electrical matching occurs as between the two adjusting transistors and between the two differential pair transistors. The two differential pair transistors are electrically connected at the source terminals to form a differential circuit. A feedback loop, which includes an amplifier, a fixed resistor and a current source complete the circuit.
Robert Chao - Santa Clara CA, US Miroslav Rapta - Sunnyvale CA, US Pierre-Jean Colson - San Francisco CA, US Junning Lee - El Granada CA, US
Assignee:
Theravance, Inc. - South San Francisco CA
International Classification:
C07D 211/56 C07D 211/72 A61K 31/47
US Classification:
514317, 546224, 546304, 546312
Abstract:
The invention provides a crystalline naphthalene-1,5-disulfonic acid salt of biphenyl-2-ylcarbamic acid 1-{9-[(R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydro-quinolin-5 -yl)ethylamino]nonyl}piperidin-4-yl ester or a solvate thereof. This invention also provides pharmaceutical compositions comprising such a salt or prepared using such a salt; processes and intermediates for preparing such a salt; and methods of using such a salt to treat a pulmonary disorder.
Robert S. Chao - Santa Clara CA, US Miroslav Rapta - Sunnyvale CA, US Pierre-Jean Colson - San Francisco CA, US
Assignee:
Theravance, Inc. - South San Francisco CA
International Classification:
C07D 453/04 C07D 211/56
US Classification:
546135, 546224, 546242
Abstract:
The invention provides a crystalline 1,2-ethanedisulfonic acid salt of biphenyl-2-ylcarbamic acid 1-[2-(2-chloro-4-{[(R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino]methyl}-5-methoxyphenylcarbamoyl)ethyl]piperidin-4-yl ester or a solvate thereof. This invention also provides pharmaceutical compositions comprising such a salt or prepared using such a salt; processes and intermediates for preparing such a salt; and methods of using such a salt to treat a pulmonary disorder.
Crystalline Form Of A Substituted Pyrrolidine Compound
Li Li - Sunnyvale CA, US Robert Chao - Santa Clara CA, US Adam Hughes - Belmont CA, US Yu-Hua Ji - Redwood City CA, US Davar Khossravi - San Mateo CA, US Weijiang Zhang - Concord CA, US
Assignee:
Theravance, Inc. - South San Francisco CA
International Classification:
A61K 31/40 C07D 207/09
US Classification:
514428, 548571
Abstract:
The invention provides a crystalline naphthalene-1,5-disulfonic acid salt of 2-[(S)-1-(8-methylaminooctyl)pyrrolidin-3-yl]-2,2-diphenylacetamide or a solvate thereof. This invention also provides pharmaceutical compositions comprising the salt or prepared using the salt; processes and intermediates for preparing the salt; and methods of using the salt to treat a pulmonary disorder.
Crystalline Form Of An Alkoxyimidazol-1-Ylmethyl Biphenyl Carboxylic Acid
Robert S. Chao - Santa Clara CA, US Weijiang Zhang - Concord CA, US
Assignee:
Theravance, Inc. - South San Francisco CA
International Classification:
A61K 31/415 C07D 233/54
US Classification:
514398, 5483255
Abstract:
The invention provides a crystalline freebase form of 4′-{2-ethoxy-4-ethyl-5-[((S)-2-mercapto-4-methylpentanoylamino)methyl]imidazol-1-ylmethyl}-3′-fluorobiphenyl-2-carboxylic acid. This invention also provides pharmaceutical compositions comprising the crystalline compound, processes and intermediates for preparing the crystalline compound, and methods of using the crystalline compound to treat diseases such as hypertension.
Jennifer Bolton - Edinburgh, GB Robert S. Chao - Santa Clara CA, US Miroslav Rapta - Sunnyvale CA, US Lisa Williams - Santa Clara CA, US Richard D. Wilson - El Sobrante CA, US
Assignee:
Theravance, Inc. - South San Francisco CA
International Classification:
C07D 211/46 A61K 31/445
US Classification:
546222, 514327
Abstract:
The invention relates to crystalline free base forms of biphenyl-2-ylcarbamic acid 1-[2-(4-{[(R)-2-(3-formylamino-4-hydroxyphenyl)-2-hydroxyethylamino]methyl}-2,5-dimethylphenylcarbamoyl)ethyl]piperidin-4-yl ester or a solvate thereof. This invention also relates to pharmaceutical compositions containing or prepared from such crystalline forms; processes and intermediates useful for preparing such crystalline forms; and methods of using such crystalline forms to, for example, treat a pulmonary disorder.
Robert S. Chao - Santa Clara CA, US Miroslav Rapta - Sunnyvale CA, US Pierre-Jean Colson - San Francisco CA, US
Assignee:
Theravance, Inc. - South San Francisco CA
International Classification:
C07D 215/38
US Classification:
546156, 546135
Abstract:
The invention provides a crystalline 1,2-ethanedisulfonic acid salt of biphenyl-2-ylcarbamic acid 1-[2-(2-chloro-4-{[(R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino]methyl}-5-methoxyphenylcarbamoyl)ethyl]piperidin-4-yl ester or a solvate thereof. This invention also provides pharmaceutical compositions comprising such a salt or prepared using such a salt; processes and intermediates for preparing such a salt; and methods of using such a salt to treat a pulmonary disorder.
Crystalline Form Of An Alkoxyimidazol-1-Ylmethyl Biphenyl Carboxylic Acid
Robert S. Chao - Santa Clara CA, US Weijiang Zhang - Concord CA, US
Assignee:
Theravance, Inc. - South San Francisco CA
International Classification:
A61K 31/415 C07D 233/54
US Classification:
514398, 5483255
Abstract:
The invention provides a crystalline freebase form of 4′-{2-ethoxy-4-ethyl-5-[((S) -2-mercapto-4-methylpentanoylamino)methyl]imidazol-1-ylmethyl}-3′-fluorobiphenyl-2 -carboxylic acid. This invention also provides pharmaceutical compositions comprising the crystalline compound, processes and intermediates for preparing the crystalline compound, and methods of using the crystalline compound to treat diseases such as hypertension.
Burberry Jan 2017 - Jan 2018
Department Manager
Wand Fight Team Jan 2017 - Jan 2018
Instructor
Giorgio Armani Jul 2015 - Jan 2017
Sales Manager
Giorgio Armani Jun 2014 - Jul 2015
Operations Manager
Giorgio Armani Jun 2013 - Jun 2014
Department Manager
Education:
University of California, Davis 2011
University of California, Davis 2007 - 2010
Bachelors, Bachelor of Arts, Anthropology, Music
University of California
Skills:
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Capital Management The Clint Cronin Show Vandal Kimonos Kappa Kappa Gamma at Uc Davis Giorgio Armani Community Level Up Boxing and Fitness Sports League Atma Immersive Journeys Health/Beauty Grape Drank Olivia Thai Sherrard Blackledge Yoloberry Yogurt West Craig Mauro Ayres Brazilian Jiu Jitsu Mma Lydia Oliveira Train With Luck Arlington Farm Business Service Cresp Joe Aj Rafael Interest Ice Cream Shop One Ton Project Martial Arts School Movement By Jess Theta Xi of Uc Davis Abu Brothers Fight Team Personal Blog Defense Soap Gucci Tony Perez Bjj I Heart San Jose Lifehacker Tobacco Store Uc Davis Sorority and Fraternity Life Adcc Gym/Physical Fitness Center Clothing (Brand) Savita Sittler Photography Kaine Marzola Mma Creators Compound Huntridge Records Hyperfly School Sports Team Broham Smoke Shop Blogger Bakery Abu Brothers Jiu Jitsu Las Vegas Veronica Graves Mitchell's Journey Com Channa Bender Company Coach Book I San Jose Real Mixed Martial Arts Musician Yolobjj Musician/Band Newbreed Ultimate Challenge Marco Simmons Wand Fight Team Martial Arts Chris Gates Chelsie Hightower James Washington Gb Enterprises Uc Davis Men's Lacrosse Media Photographer Likeacoupon Record Label Computers and Internet Website Nonprofit Organization Website The Shih Tzu Who Knew Jiu Jitsu Jessica Chow George Tsai Artist Athlete Product/Service Local Business Demon Lung Publisher Olya's Art and Rarities Neighborhood Gracie Humaita Jiu Jitsu World League Professional Service Fight Chase 2Souls Delta Delta Delta at Uc Davis Michael Costa Mma Community Organization Public Figure Sorority and Fraternity Luka Jelčić J Bird Bakeshop Mindfray Dancer
Hewlett-Packard
Software Engineering Manager
Autonomy Oct 2007 - Jun 2011
Engineering Manager
Zantaz Jan 2005 - Oct 2007
Engineering Manager
Education:
National Taiwan Ocean University
University of California, Berkeley
Masters
Skills:
Cloud Computing Enterprise Software Agile Methodologies Distributed Systems Software Development Product Management Saas Linux Perl Hadoop Scrum Storage Virtualization Big Data Solaris