Robert Eric Doss

US Patent:

7776605, Aug 17, 2010

Filed:

Oct 26, 2006

Appl. No.:

11/588073

Inventors:

Phillip G. Mattingly - Third Lake IL, US
Maciej Adamczyk - Gurnee IL, US
Roy Jeffrey Brashear - Mundelein IL, US
Robert C. Doss - Libertyville IL, US

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

G01N 31/00
G01N 33/53

US Classification:

436 8, 435 71, 435 79, 436 10, 436175, 436506, 436513, 436518, 436523, 436524, 436528, 436540

Abstract:

The invention provides among other things methods and kits based on assaying for cardiac troponin autoantibodies, either in conjunction with an assay for cardiac troponin and/or as an independent indicator of cardiac pathology, such as myocarditis, cardiomyopathy, and/or ischemic heart disease. Assay methods of the invention can be employed among other things to identify cardiac pathology, or risk thereof, in subjects who have an autoimmune disease or who are related to an individual with an autoimmune disease. In particular embodiments, the invention also provides a method of determining whether a subject having, or at risk for, a cardiac pathology is a candidate for immunosuppressive therapy or immunoabsorption therapy. The invention also provides kits and kit components that are useful for performing the methods of the invention.

US Patent:

8173382, May 8, 2012

Filed:

Aug 17, 2010

Appl. No.:

12/857615

Inventors:

Phillip G. Mattingly - Third Lake IL, US
Maciej Adamczyk - Gurnee IL, US
Roy Jeffrey Brashear - Mundelein IL, US
Robert C. Doss - Libertyville IL, US

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

G01N 31/00
G01N 33/53

US Classification:

435 793, 435 71, 436 8, 436 10, 436175, 436506, 436518, 436523, 436524, 436528, 436540

Abstract:

The invention provides among other things methods and kits based on assaying for cardiac troponin autoantibodies, either in conjunction with an assay for cardiac troponin and/or as an independent indicator of cardiac pathology, such as myocarditis, cardiomyopathy, and/or ischemic heart disease. Assay methods of the invention can be employed among other things to identify cardiac pathology, or risk thereof, in subjects who have an autoimmune disease or who are related to an individual with an autoimmune disease. In particular embodiments, the invention also provides a method of determining whether a subject having, or at risk for, a cardiac pathology is a candidate for immunosuppressive therapy or immunoabsorption therapy. The invention also provides kits and kit components that are useful for performing the methods of the invention.

US Patent:

20080305512, Dec 11, 2008

Filed:

Nov 2, 2007

Appl. No.:

11/934688

Inventors:

Phillip G. Mattingly - Third Lake IL, US
Maciej Adamczyk - Gurnee IL, US
Roy Jeffrey Brashear - Mundelein IL, US
Robert C. Doss - Libertyville IL, US

International Classification:

C12Q 1/28
G01N 33/564

US Classification:

435 28, 436506

Abstract:

The invention provides among other things methods and kits based on assaying for cardiac troponin autoantibodies, either in conjunction with an assay for cardiac troponin and/or as an independent indicator of cardiac pathology, such as myocarditis, cardiomyopathy, and/or ischemic heart disease. Assay methods of the invention can be employed among other things to identify cardiac pathology, or risk thereof, in subjects who have an autoimmune disease or who are related to an individual with an autoimmune disease. In particular embodiments, the invention also provides a method of determining whether a subject having, or at risk for, a cardiac pathology is a candidate for immunosuppressive therapy or immunoabsorption therapy. The invention also provides kits and kit components that are useful for performing the methods of the invention.