Robert T Mcfadden

US Patent:

6365208, Apr 2, 2002

Filed:

Oct 3, 1997

Appl. No.:

08/943827

Inventors:

Sunanda R. Kulkarni - N. Wales PA
Robert T. McFadden - Congers NY
David H. Rogers - Ambler PA

Assignee:

McNeil-PPC, Inc. - Skillman NJ

International Classification:

A23L 128

US Classification:

426 61, 426 63, 426285, 426573, 435188

Abstract:

There is a formulation having improved chemical stability containing: a) from about 1% to about 20% by weight of a combination of lactase and cutting agent where said combination has from 0 to about 4 parts by weight cutting agent for each part by weight lactase; b) from about 1% to about 98% by weight of microcrystalline cellulose; c) from about 0% to about 97% by weight of mannitol; and d) an effective amount of lubricant to aid compression.

US Patent:

6660313, Dec 9, 2003

Filed:

Feb 4, 2002

Appl. No.:

10/067078

Inventors:

Sunanda R. Kulkarni - N. Wales PA
Robert T. McFadden - Congers NY
David H. Rogers - Ambler PA

Assignee:

McNeil-PPC, Inc. - Skillman NJ

International Classification:

A23L 128

US Classification:

426 61, 426 63, 426285, 426573, 435188

Abstract:

There is a formulation having improved chemical stability comprising: a) from about 1% to about 20% by weight of a combination of lactase and cutting agent where said combination has from 0 to about 4 parts by weight cutting agent for each part by weight lactase; b) from about 1% to about 98% by weight of microcrystalline cellulose; c) from about 0% to about 97% by weight of mannitol; and d) an effective amount of lubricant to aid compression.

US Patent:

6955903, Oct 18, 2005

Filed:

Nov 2, 2001

Appl. No.:

10/001733

Inventors:

Sunanda R. Kulkarni - N. Wales PA, US
Robert T. McFadden - Congers NY, US
David H. Rogers - Ambler PA, US

Assignee:

McNeil-PPC - Skillman NJ

International Classification:

C12N009/96
C12N011/12
A61K038/47
A61K009/20

US Classification:

435188, 424 9461, 424464, 424465, 435179, 435200, 435207

Abstract:

A preblend for making lactase tablets is prepared containing about 1-99% (preferably about 200-60%) by weight lactase and about 1-99% (preferably about 40-80%) by weight microcrystalline cellulose. Lactase used in the preblend may be in combination with up to about 4 parts (preferably about 0. 5-2 parts) by weight cutting agent such as sugars, starches, cellulose, and inorganic salts for each part by weight lactase. About 0. 5-4% by weight lubricant such as magnesium stearate may be present in the preblend. A preferred preblend contains about 9. 6 weight percent lactase and about 90 weight percent microcrystalline cellulose, or about 2000 to about 9000 FCC lactase units and from about 40 to about 80 weight percent microcrystalline cellulose. Another preferred preblend contains about 9. 6 weight percent lactase, about 30.

US Patent:

6057139, May 2, 2000

Filed:

Jun 29, 1995

Appl. No.:

8/496824

Inventors:

Sunanda R. Kulkarni - N. Wales PA
Robert T. McFadden - Congers NY
David H. Rogers - Ambler PA
James T. Walter - Ambler PA

Assignee:

McNeil-PPC, Inc. - Skillman NJ

International Classification:

C12N 996
C12N 1112
A61K 3847
A61K 920

US Classification:

435188

Abstract:

A preblend for making lactase tablets is prepared containing about 1-99% (preferably about 20-60%) by weight lactase and about 1-99% (preferably about 40-80%) by weight microcrystalline cellulose. Lactase used in the preblend may be in combination with up to about 4 parts (preferably about 0. 5-2 parts) by weight cutting agent such as sugars, starches, cellulose, and inorganic salts for each part by weight lactase. About 0. 5-4% by weight lubricant such as magnesium stearate may be present in the preblend. A preferred preblend contains about 9. 6 weight percent lactase and about 90 weight percent microcrystalline cellulose. Another preferred preblend contains about 9. 6 weight percent lactase, about 30. 0 weight percent microcrystalline cellulose and about 59. 4 weight percent mannitol.